{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:15:05Z","timestamp":1785413705636,"version":"3.56.0"},"reference-count":35,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"unspecified","delay-in-days":123,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Expert Rev. Mol. Med."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1462399426100489_sec1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acupuncture is increasingly used during in vitro fertilization and embryo transfer (IVF-ET), but its therapeutic benefits for women with polycystic ovary syndrome (PCOS) remain uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1462399426100489_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eight databases were investigated from the inception until April 1, 2024. We screened randomized controlled trials (RCTs) using acupuncture undergoing IVF-ET, the population was patients with PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1462399426100489_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We analyzed 13 RCTs with 1,203 patients. Acupuncture significantly improved clinical pregnancy rate (P &lt; 0.01), high-quality embryo rate (P &lt; 0.01), and live birth rate (P &lt; 0.01). It also reduced gonadotropin (Gn) dose (P = 0.0002), Gn duration (P = 0.005), and OHSS incidence (P &lt; 0.01). No significant differences were seen in fertilization rate, oocyte yield, endometrial thickness, progesterone, LH, E2, miscarriage rate, or cycle cancellation rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1462399426100489_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results showed that acupuncture therapy could increase the high-quality embryo rate, live birth rate and also the clinical pregnancy rate in PCOS patients undergoing IVF. Acupuncture could reduce the dose and duration of Gn. It also decreased the incidence of OHSS. Based on the result of this meta-analysis, acupuncture therapy is suggested in the IVF process for PCOS patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/erm.2026.10048","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:54:30Z","timestamp":1777881270000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Acupuncture in Women with Polycystic Ovary Syndrome Undergoing in vitro Fertilization: A Systematic Review and Meta-Analysis"],"prefix":"10.1017","volume":"28","author":[{"given":"Lina","family":"Yi","sequence":"first","affiliation":[{"name":"Peking University Third Hospital"},{"name":"Peking University Third Hospital"},{"name":"Ministry of Education"},{"id":[{"id":"https:\/\/ror.org\/04wwqze12","id-type":"ROR","asserted-by":"publisher"}],"name":"Peking University Third Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haolin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital"},{"name":"Peking University Third Hospital"},{"name":"Ministry of Education"},{"id":[{"id":"https:\/\/ror.org\/04wwqze12","id-type":"ROR","asserted-by":"publisher"}],"name":"Peking University Third Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Tian","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital"},{"name":"Peking University Third Hospital"},{"name":"Ministry of Education"},{"id":[{"id":"https:\/\/ror.org\/04wwqze12","id-type":"ROR","asserted-by":"publisher"}],"name":"Peking University Third Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6384-5372","authenticated-orcid":false,"given":"Yaodong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University 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Education"},{"id":[{"id":"https:\/\/ror.org\/04wwqze12","id-type":"ROR","asserted-by":"publisher"}],"name":"Peking University Third Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital"},{"name":"Peking University Third Hospital"},{"name":"Ministry of Education"},{"id":[{"id":"https:\/\/ror.org\/04wwqze12","id-type":"ROR","asserted-by":"publisher"}],"name":"Peking University Third Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Ma","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital"},{"name":"Peking University Third Hospital"},{"name":"Ministry of Education"},{"id":[{"id":"https:\/\/ror.org\/04wwqze12","id-type":"ROR","asserted-by":"publisher"}],"name":"Peking University Third Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital"},{"name":"Peking University Third Hospital"},{"name":"Ministry of Education"},{"id":[{"id":"https:\/\/ror.org\/04wwqze12","id-type":"ROR","asserted-by":"publisher"}],"name":"Peking University Third Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0305-5579","authenticated-orcid":false,"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital"},{"name":"Peking University Third Hospital"},{"name":"Ministry of Education"},{"id":[{"id":"https:\/\/ror.org\/04wwqze12","id-type":"ROR","asserted-by":"publisher"}],"name":"Peking University Third Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Qiao","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital"},{"name":"Peking University Third Hospital"},{"name":"Ministry of Education"},{"id":[{"id":"https:\/\/ror.org\/04wwqze12","id-type":"ROR","asserted-by":"publisher"}],"name":"Peking University Third Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Huang","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital"},{"name":"Peking University Third Hospital"},{"name":"Ministry of Education"},{"id":[{"id":"https:\/\/ror.org\/04wwqze12","id-type":"ROR","asserted-by":"publisher"}],"name":"Peking University Third Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6381-5202","authenticated-orcid":false,"given":"Rui","family":"Yang","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital"},{"name":"Peking University Third Hospital"},{"name":"Ministry of 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The Journal of the Pakistan Medical Association"},{"key":"S1462399426100489_r5","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.1938914"},{"key":"S1462399426100489_r28","first-page":"48","article-title":"Effects of acupuncture method of strengthing spleen and invigorating kidney on ovulation and endometrial receptivity of infertile patients with PCOS in IVF-ET","author":"Cai","year":"2020","journal-title":"Shanghai Journal of Traditional Chinese Medicine"},{"key":"S1462399426100489_r6","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew218"},{"key":"S1462399426100489_r25","unstructured":"25. Yang, T (2013) Mechanism of Acupuncture on Decreasing the Incidence of OHSS in IVF-ET Treatment. MA thesis, Lanzhou University."},{"key":"S1462399426100489_r13","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.5336"},{"key":"S1462399426100489_r17","first-page":"4262","article-title":"Investigation on effect of electroacupuncture intervention on in vitro fertilization and embryo transfer of patients with polycystic ovarian syndrome","volume":"24","author":"Jun","year":"2009","journal-title":"Maternal and Child Health Care of China"},{"key":"S1462399426100489_r31","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-019-1990-3"},{"key":"S1462399426100489_r33","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19113500"},{"key":"S1462399426100489_r23","first-page":"ED000142","article-title":"Updated guidance for trusted systematic reviews: A new edition of the Cochrane handbook for systematic reviews of interventions","volume":"10","author":"Cumpston","year":"2019","journal-title":"The Cochrane Database of Systematic Reviews"},{"key":"S1462399426100489_r20","first-page":"16","article-title":"Impact of transcutaneous electrical nerve stimulation (TENS) on endometrial thickness in the healthy women, a step to improve the female fertility","volume":"4","author":"Ajeena","year":"2018","journal-title":"Journal of Contemporary Medical Sciences"},{"key":"S1462399426100489_r12","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)03273-3"},{"key":"S1462399426100489_r2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.05.003"},{"key":"S1462399426100489_r35","first-page":"505","article-title":"Effect of electro-acupuncture on tumor necrosis factor-\u03b1 and vascular endothelial growth factor in peripheral blood and joint synovia of patients with rheumatoid arthritis.Chin","volume":"17","author":"Ouyang","year":"2011","journal-title":"Journal of Integrative Medicine"},{"key":"S1462399426100489_r4","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002656"},{"key":"S1462399426100489_r24","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2012-010198"},{"key":"S1462399426100489_r19","first-page":"565","article-title":"Effect of Tiao Ren Tong Du needling method on pregnancy outcome after IVF-ET for infertility due to polycystic ovary syndrome","volume":"40","author":"Wu","year":"2021","journal-title":"Shanghai Journal of Acupuncture and Moxibustion"},{"key":"S1462399426100489_r7","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.615957"},{"key":"S1462399426100489_r15","unstructured":"15. Li, Y (2011) Clinical Study on Effect of Electro-Acupuncture in Improving the Quality of Oocytes and Leukemia Inhibitory Factor in Follicular Fluid of Polycystic Ovarian Syndrome Patients Undergoing in vitro Fertilization and Embryo Transfer. MA thesis, Shandong University of Traditional Chinese Medicine."},{"key":"S1462399426100489_r9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39471.430451.BE"},{"key":"S1462399426100489_r29","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-022-3498-z"},{"key":"S1462399426100489_r22","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.10.004"},{"key":"S1462399426100489_r14","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-022-00997-0"},{"key":"S1462399426100489_r30","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112288"},{"key":"S1462399426100489_r18","first-page":"687","article-title":"Zhongguo zhen jiu =","volume":"31","author":"Cui","year":"2011","journal-title":"Chinese Acupuncture and Moxibustion"},{"key":"S1462399426100489_r1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2010.217"},{"key":"S1462399426100489_r10","first-page":"2241","article-title":"Impact of acupuncture combined with medicine on IVF-ET fertility outcomes of polycystic ovary patients with kidney deficiency and phlegm dampness syndrome","volume":"10","author":"Guo","year":"2022","journal-title":"Acta Chinese Medicine"},{"key":"S1462399426100489_r8","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13061578"},{"key":"S1462399426100489_r11","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.06.005"},{"key":"S1462399426100489_r27","first-page":"2755","article-title":"Efficacy observation of staged acupuncture and moxibustion therapy based on the theory of thorough fare vessel being sea of blood\u2019on frozen-thawed embryo transfer in patients with polycystic ovary syndrome","volume":"37","author":"Xing","year":"2022","journal-title":"Clinical Traditional Medicine and Pharmacology"},{"key":"S1462399426100489_r26","first-page":"151","article-title":"Zhen ci yan jiu =","volume":"40","author":"Yang","year":"2015","journal-title":"Acupuncture Research"},{"key":"S1462399426100489_r21","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-020-3219-z"},{"key":"S1462399426100489_r32","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-022-01078-x"},{"key":"S1462399426100489_r3","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2022.100494"},{"key":"S1462399426100489_r34","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-023-01113-6"}],"container-title":["Expert Reviews in Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1462399426100489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T07:08:26Z","timestamp":1784272106000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1462399426100489\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":35,"alternative-id":["S1462399426100489"],"URL":"https:\/\/doi.org\/10.1017\/erm.2026.10048","relation":{},"ISSN":["1462-3994"],"issn-type":[{"value":"1462-3994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided that no alterations are made and the original article is properly cited. The written permission of Cambridge University Press or the rights holder(s) must be obtained prior to any commercial use and\/or adaptation of the article.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e21"}}