{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T05:16:19Z","timestamp":1792905379817,"version":"4.5.0"},"reference-count":98,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"unspecified","delay-in-days":127,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Expert Rev. Mol. Med."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1462399426100507_sec01\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nerve growth factor (NGF), which acts on receptors tropomyosin receptor kinase A and p75 neurotrophic receptor, is a member of neurotrophin family and a kind of secretory polypeptides.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1462399426100507_sec02\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature search was conducted in the following databases: PubMed and Web of Science. The following search terms were used in various combinations: \u201cNGF,\u201d \u201cnerve growth factor,\u201d \u201covarian steroidogenesis,\u201d \u201cfollicular development,\u201d \u201coocyte maturation,\u201d and \u201covulation.\u201d Boolean operators (AND, OR) were applied to combine search terms (e.g., \u201cNGF AND PCOS,\u201d \u201cNGF AND follicular development\u201d).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1462399426100507_sec03\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>NGF plays important roles in multiple reproductive physiological activities. Its ovarian effects are crucial for oocyte maturation, follicular assembly, early follicle development, ovulation and steroidogenesis. While the ovary is a major target, NGF\u2019s role extends to the broader regulation of the female reproductive system. In particular, the role of NGF in inducing ovulation by acting on the hypothalamus has garnered considerable scholarly attention. Although relatively few studies have examined the direct impact of NGF on hypothalamic gonadotrophin-releasing hormone neurons\u2014the central regulators of the hypothalamic\u2013pituitary\u2013ovary (HPO) axis, extensive evidence demonstrates that NGF can cause an influence on the synthesis and release of follicle-stimulating hormone, luteinizing hormone and steroid hormones, which act downstream in the HPO axis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1462399426100507_sec04\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our review outlines the critical role of NGF in female reproductive physiology, with a particular focus on its modulatory influence on induced ovulation. Furthermore, in this review, we aim to provide a more comprehensive perspective on NGF\u2019s role in reproductive disorders, such as polycystic ovary syndrome, diminished ovarian reserve and endometriosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/erm.2026.10050","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T07:56:27Z","timestamp":1778226987000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Modulation of Female Reproductive Functions through Nerve Growth Factor: A Systematic Review"],"prefix":"10.1017","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1558-2893","authenticated-orcid":false,"given":"Yanru","family":"Lou","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04wwqze12","id-type":"ROR","asserted-by":"publisher"}],"name":"Peking University Third 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