{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:31:28Z","timestamp":1785403888702,"version":"3.56.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"unspecified","delay-in-days":182,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Expert Rev. Mol. Med."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Colorectal cancer (CRC), a major global health burden, is the second leading cause of cancer deaths. This review examines the link between\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection and CRC, highlighting its role beyond gastric pathology. Affecting over half the world\u2019s population,\n                    <jats:italic>H. pylori<\/jats:italic>\n                    is associated with increased CRC risk through direct and indirect mechanisms. Direct pathways include toxins like CagA and VacA, which drive inflammation, and hypergastrinaemia, which promotes colorectal cell proliferation. Indirectly,\n                    <jats:italic>H. pylori<\/jats:italic>\n                    induces immune dysregulation, shifts to immune-evasive coccoid forms, survives intracellularly, releases oncogenic vesicles, disrupts autophagy, alters non-coding RNAs by dysregulating their expression profiles and contributes to gut microbiota dysbiosis. Additionally, we discuss the potential of probiotic interventions to counteract\n                    <jats:italic>H. pylori<\/jats:italic>\n                    \u2019s pathogenic effects by restoring gut microbial balance, reducing inflammation and modulating immunity by regulating cytokine and T-cell profiles. Future research should translate these molecular insights into clinical applications, including evaluating whether\n                    <jats:italic>H. pylori<\/jats:italic>\n                    eradication reduces CRC risk in high-risk populations and assessing the preventive potential of specific probiotic strains in controlled human trials.\n                  <\/jats:p>","DOI":"10.1017\/erm.2026.10063","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:04:52Z","timestamp":1782975892000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Beyond the Stomach: Exploring the Role of\n                    <i>Helicobacter pylori<\/i>\n                    in Pushing Precancerous Lesions to Colorectal Cancer and the Therapeutic Potential of Probiotics"],"prefix":"10.1017","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4999-5697","authenticated-orcid":false,"given":"Zahra","family":"Sadeghloo","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/034m2b326","id-type":"ROR","asserted-by":"publisher"}],"name":"Shahid Beheshti University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Azizmohammad Looha","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/034m2b326","id-type":"ROR","asserted-by":"publisher"}],"name":"Shahid Beheshti University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6477-770X","authenticated-orcid":false,"given":"Marziyeh","family":"Etesami","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/034m2b326","id-type":"ROR","asserted-by":"publisher"}],"name":"Shahid Beheshti University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2577-5294","authenticated-orcid":false,"given":"Georg","family":"Conrads","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02gm5zw39","id-type":"ROR","asserted-by":"publisher"}],"name":"RWTH University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sama","family":"Rezasoltani","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02gm5zw39","id-type":"ROR","asserted-by":"publisher"}],"name":"RWTH University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Sadeghi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/034m2b326","id-type":"ROR","asserted-by":"publisher"}],"name":"Shahid Beheshti University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsan","family":"Nazemalhosseini Mojarad","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/034m2b326","id-type":"ROR","asserted-by":"publisher"}],"name":"Shahid Beheshti University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,7,2]]},"container-title":["Expert Reviews in Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1462399426100635","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:08:17Z","timestamp":1784290097000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1462399426100635\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"alternative-id":["S1462399426100635"],"URL":"https:\/\/doi.org\/10.1017\/erm.2026.10063","relation":{},"ISSN":["1462-3994"],"issn-type":[{"value":"1462-3994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e32"}}