{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:48:59Z","timestamp":1792064939198,"version":"4.4.0"},"reference-count":87,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"unspecified","delay-in-days":287,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Expert Rev. Mol. Med."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1462399426100751_sec1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Immune-related diseases contribute substantially to global morbidity and mortality. CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells play a critical role in adaptive immunity by eliminating virus-infected and malignant cells. The biology of CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells is governed by tightly regulated gene expression programs, and disruption of these programs can lead to diverse immunopathologies and malignancies. This article evaluates our current understanding of post-transcriptional and translational regulation of gene expression in CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells by RNA-binding proteins.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1462399426100751_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Relevant and up-to-date literature was critically analysed to gain mechanistic insights into the roles of RNA-binding proteins in CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cell biology and to identify key knowledge gaps and future directions, with particular emphasis on therapeutic implications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1462399426100751_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      RNA-binding proteins regulate diverse aspects of CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cell biology, including differentiation, cytokine production, stress adaptation and proliferation. Recent studies further reveal how dysregulated expression and function of RNA-binding proteins contribute to hyperinflammation and haematological malignancies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1462399426100751_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      RNA-binding proteins are emerging as key post-transcriptional and translational checkpoint regulators of CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cell biology and represent promising therapeutic targets for immune-related diseases; however, substantial mechanistic and disease-specific studies, as well as rigorous translational validation, are required before RNA-binding protein-targeted therapeutic strategies can be safely and effectively advanced into clinical practice.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/erm.2026.10075","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:58:01Z","timestamp":1792061881000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["RNA-Binding Proteins Regulate CD8\n                    <sup>+<\/sup>\n                    T Cell Biology: Mechanisms and Therapeutic Opportunities"],"prefix":"10.1017","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4805-3465","authenticated-orcid":false,"given":"Ashwin B. 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