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Using\n                    <jats:italic>senescence marker protein<\/jats:italic>\n                    30 knockout (\n                    <jats:italic>SMP<\/jats:italic>\n                    30 KO) mice\u2014models that mimic human vitamin C (vitC) deficiency and exhibit accelerated aging\u2014we investigated the effects of bioactive ceramic processed water (BCP) compared to natural mineral water (MW) and MW supplemented with vitamin C (MW-vitC) on gut microbial communities and hepatic metabolism. Due to pooled fecal sampling (n=1 composite library per group), microbiome results represent descriptive trends in diversity and composition. BCP was associated with discernible shifts in gut microbiota, including increased abundances of beneficial genera, such as\n                    <jats:italic>Akkermansia<\/jats:italic>\n                    ,\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    , and\n                    <jats:italic>Allobaculum<\/jats:italic>\n                    , and the Muribaculaceae family. PICRUSt2 functional analysis suggested an enrichment in secondary metabolite biosynthesis, vitamin (e.g., retinol) metabolism, and xenobiotic biodegradation pathways. Furthermore, BCP was associated with significantly higher levels of activated hepatic AMP-activated protein kinase (AMPK), a key energy metabolism regulator, compared to control groups. Although microbiome findings are descriptive due to the study design, these results suggest BCP as a potential dietary intervention to help mitigate age-related metabolic decline and promote healthy ageing.\n                  <\/jats:p>","DOI":"10.1017\/gmb.2026.10018","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T08:57:37Z","timestamp":1769072257000},"source":"Crossref","is-referenced-by-count":0,"title":["Bioactive ceramic-processed water modulates the gut microbiota and hepatic AMPK activation in\n                    <i>SMP30<\/i>\n                    knockout mice"],"prefix":"10.1017","volume":"7","author":[{"given":"Dong-Hun","family":"Kim","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/044k0pw44","id-type":"ROR","asserted-by":"publisher"}],"name":"Korea Institute of Geoscience and Mineral 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