{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:18:53Z","timestamp":1785410333866,"version":"3.56.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"unspecified","delay-in-days":151,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut. Microb."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Studies characterising the immunoglobulin (Ig)-bound microbiota apply varying methodologies, making comparisons difficult. This scoping review synthesised evidence on Ig\u2013microbiota binding patterns in maternal and infant contexts, identified recurrent Ig-bound and -unbound bacteria across studies, and highlighted knowledge gaps for further study. Nine articles investigating Ig\u2013microbiota binding patterns in stool or breastmilk samples in mothers or infants were included. Ig\u2013microbiota associations were influenced by sample type, Ig-subclass, genetics, and diet. The most important antibody was IgA, with partial functional redundancy with IgM, while IgG appeared more selective for pathobionts. Ig-bound taxa in early life included important commensals and pathobionts, with high levels of individuality. Ig\u2013microbiota associations shifted with microbiome maturation, environmental and host factors, resembling adults at around 2 years of age. Transfer of Ig-bound\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    through breastmilk may contribute to vertical transmission from mother to infant. Ig\u2013microbiota associations also differed between health and disease states, beyond the overall microbiota. Results were limited by study numbers and a lack of methodological consistency. We propose the standardised term \u201cIg-Seq\u201d in referring to the technique to study Ig\u2013microbiota binding patterns, and suggest standardisation of laboratory protocols, bioinformatic pipelines, and statistical analyses to improve consistency in Ig-Seq.\n                  <\/jats:p>","DOI":"10.1017\/gmb.2026.10028","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T08:21:12Z","timestamp":1780302072000},"source":"Crossref","is-referenced-by-count":0,"title":["Ig\u2013microbiota binding patterns in mothers and infants: a scoping review"],"prefix":"10.1017","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7533-0122","authenticated-orcid":false,"given":"Alicia Tan","family":"Yi Jia","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02n415q13","id-type":"ROR","asserted-by":"publisher"}],"name":"Curtin University, Bentley, WA"},{"id":[{"id":"https:\/\/ror.org\/02n415q13","id-type":"ROR","asserted-by":"publisher"}],"name":"Curtin University, Bentley, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher S.","family":"Peacock","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/047272k79","id-type":"ROR","asserted-by":"publisher"}],"name":"The University of Western Australia, Nedlands, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle E.","family":"Dye","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02n415q13","id-type":"ROR","asserted-by":"publisher"}],"name":"Curtin University, Bentley, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus T.","family":"Christophersen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02n415q13","id-type":"ROR","asserted-by":"publisher"}],"name":"Curtin University, Bentley, WA"},{"id":[{"id":"https:\/\/ror.org\/05jhnwe22","id-type":"ROR","asserted-by":"publisher"}],"name":"Edith Cowan University, Joondalup, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,6,1]]},"container-title":["Gut Microbiome"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2632289726100280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T12:11:30Z","timestamp":1781698290000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2632289726100280\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"alternative-id":["S2632289726100280"],"URL":"https:\/\/doi.org\/10.1017\/gmb.2026.10028","relation":{},"ISSN":["2632-2897"],"issn-type":[{"value":"2632-2897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e12"}}