{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T16:10:03Z","timestamp":1772122203701,"version":"3.50.1"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"unspecified","delay-in-days":56,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Camb. prisms Glob. ment. health"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The objective of this study was to investigate the impact of common mental disorder (CMD; depression\/anxiety) symptoms and risky substance use in people with epilepsy in Ethiopia (four districts) on quality of life (QoL) and functioning over 6\u00a0months. A prospective cohort study was carried out. Multivariable linear regression followed by structural equation modelling (SEM) was employed. In the multivariable regression model, neither CMD symptoms (\u03b2 coef.\u00a0=\u00a0\u22120.37, 95% confidence interval [CI] \u22121.30, +0.55) nor moderate to high risk of alcohol use (\u03b2 coef.\u00a0=\u00a0\u22120.70, 95% CI \u22129.20, +7.81) were significantly associated with a change in QoL. In SEM, the summative effect of CMD on QoL was significant (B\u00a0=\u00a0\u22120.27, 95% CI \u22120.48, \u22120.056). Change in functional disability was not significantly associated with common mental disorder (CMD) symptoms (\u03b2 coef.\u00a0=\u00a0\u22120.03, 95% CI \u22120.48, +0.54) or with moderate to high risk of alcohol use (\u03b2 coef.\u00a0=\u00a0\u22121.31, 95% CI \u22125.89, 3.26). In the SEM model, functional disability was predicted by both CMD symptoms (B\u00a0=\u00a00.24, 95% CI 0.06, 0.41) and seizure frequency (B\u00a0=\u00a00.67, 95% CI 0.46, 0.87). In this rural Ethiopian setting, co-morbid CMD symptoms and seizure frequency independently predicted functional disability in people with epilepsy.<\/jats:p>","DOI":"10.1017\/gmh.2025.24","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T01:57:12Z","timestamp":1740535032000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Impact of co-morbid common mental disorder symptoms in people with epilepsy in Ethiopia on quality of life and functional disability: a cohort study"],"prefix":"10.1017","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4957-5820","authenticated-orcid":false,"given":"Ruth","family":"Tsigebrhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Girmay","family":"Medhin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merga","family":"Belina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles R.","family":"Newton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7937-3226","authenticated-orcid":false,"given":"Charlotte","family":"Hanlon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,2,26]]},"container-title":["Cambridge Prisms: Global Mental Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S205442512500024X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T06:17:30Z","timestamp":1741760250000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S205442512500024X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"alternative-id":["S205442512500024X"],"URL":"https:\/\/doi.org\/10.1017\/gmh.2025.24","relation":{"has-review":[{"id-type":"doi","id":"10.1017\/gmh.2025.24.pr1","asserted-by":"object"},{"id-type":"doi","id":"10.1017\/gmh.2025.24.pr2","asserted-by":"object"},{"id-type":"doi","id":"10.1017\/gmh.2025.24.pr3","asserted-by":"object"},{"id-type":"doi","id":"10.1017\/gmh.2025.24.pr4","asserted-by":"object"},{"id-type":"doi","id":"10.1017\/gmh.2025.24.pr5","asserted-by":"object"},{"id-type":"doi","id":"10.1017\/gmh.2025.24.pr6","asserted-by":"object"},{"id-type":"doi","id":"10.1017\/gmh.2025.24.pr7","asserted-by":"object"},{"id-type":"doi","id":"10.1017\/gmh.2025.24.pr8","asserted-by":"object"},{"id-type":"doi","id":"10.1017\/gmh.2025.24.pr9","asserted-by":"object"}]},"ISSN":["2054-4251"],"issn-type":[{"value":"2054-4251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e33"}}