{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:10:32Z","timestamp":1791220232309,"version":"4.1.0"},"reference-count":42,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T00:00:00Z","timestamp":1420416000000},"content-version":"unspecified","delay-in-days":4,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec id=\"S0899823X14000014_abs1\" sec-type=\"general\"><jats:title>OBJECTIVE<\/jats:title><jats:p>To explore the economic impact to a hospital of universal methicillin-resistant<jats:italic>Staphylococcus aureus<\/jats:italic>(MRSA) screening.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X14000014_abs2\" sec-type=\"methods\"><jats:title>METHODS<\/jats:title><jats:p>We used a decision tree model to estimate the direct economic impact to an individual hospital of starting universal MRSA screening and contact precautions. Projected costs and benefits were based on literature-derived data. Our model examined outcomes of several strategies including non-nares MRSA screening and comparison of culture versus polymerase chain reaction\u2013based screening.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X14000014_abs3\" sec-type=\"results\"><jats:title>RESULTS<\/jats:title><jats:p>Under baseline conditions, the costs of universal MRSA screening and contact precautions outweighed the projected benefits generated by preventing MRSA-related infections, resulting in economic costs of $104,000 per 10,000 admissions (95% CI, $83,000\u2013$126,000). Cost-savings occurred only when the model used estimates at the extremes of our key parameters. Non-nares screening and polymerase chain reaction\u2013based testing, both of which identified more MRSA-colonized persons, resulted in more MRSA infections averted but increased economic costs of the screening program.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X14000014_abs4\" sec-type=\"conclusions\"><jats:title>CONCLUSIONS<\/jats:title><jats:p>We found that universal MRSA screening, although providing potential benefit in preventing MRSA infection, is relatively costly and may be economically burdensome for a hospital. Policy makers should consider the economic burden of MRSA screening and contact precautions in relation to other interventions when choosing programs to improve patient safety and outcomes.<\/jats:p><jats:p>Infect Control Hosp Epidemiol 2015;36(1): 2\u201313<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2014.1","type":"journal-article","created":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T05:23:36Z","timestamp":1420435416000},"page":"2-13","source":"Crossref","is-referenced-by-count":34,"title":["Cost-Benefit Analysis from the Hospital Perspective of Universal Active Screening Followed by Contact Precautions for Methicillin-Resistant<i>Staphylococcus aureus<\/i>Carriers"],"prefix":"10.1017","volume":"36","author":[{"given":"James A.","family":"McKinnell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M.","family":"Bartsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce Y.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan S.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loren G.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,1,5]]},"reference":[{"key":"#cr-split#-S0899823X14000014_ref33.1","unstructured":"1. 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