{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:56:23Z","timestamp":1790013383636,"version":"4.0.1"},"reference-count":39,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec id=\"S0899823X15001440_abs1\" sec-type=\"general\"><jats:title>BACKGROUND<\/jats:title><jats:p>Infections cause morbidity and mortality in neonatal intensive care units (NICUs). The association between nursery design and nosocomial infections is unclear.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X15001440_abs2\" sec-type=\"general\"><jats:title>OBJECTIVE<\/jats:title><jats:p>To determine whether rates of colonization by methicillin-resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA), late-onset sepsis, and mortality are reduced in single-patient rooms.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X15001440_abs3\" sec-type=\"general\"><jats:title>DESIGN<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X15001440_abs4\" sec-type=\"general\"><jats:title>SETTING<\/jats:title><jats:p>NICU in a tertiary referral center.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X15001440_abs5\" sec-type=\"methods\"><jats:title>METHODS<\/jats:title><jats:p>Our NICU is organized into single-patient and open-unit rooms. Clinical data sets including bed location and microbiology results were examined over 29 months. Differences in outcomes between bed configurations were determined by \u03c7<jats:sup>2<\/jats:sup> and Cox regression.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X15001440_abs6\" sec-type=\"general\"><jats:title>PATIENTS<\/jats:title><jats:p>All NICU patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X15001440_abs7\" sec-type=\"results\"><jats:title>RESULTS<\/jats:title><jats:p>Among 1,823 patients representing 55,166 patient-days, single-patient and open-unit models had similar incidences of MRSA colonization and MRSA colonization-free survival times. Average daily census was associated with MRSA colonization rates only in single-patient rooms (hazard ratio, 1.31; <jats:italic>P=.<\/jats:italic>039), whereas hand hygiene compliance on room entry and exit was associated with lower colonization rates independent of bed configuration (hazard ratios, 0.834 and 0.719 per 1% higher compliance, respectively). Late-onset sepsis rates were similar in single-patient and open-unit models as were sepsis-free survival and the combined outcome of sepsis or death. After controlling for demographic, clinical, and unit-based variables, multivariate Cox regression demonstrated that bed configuration had no effect on MRSA colonization, late-onset sepsis, or mortality.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X15001440_abs8\" sec-type=\"conclusions\"><jats:title>CONCLUSIONS<\/jats:title><jats:p>MRSA colonization rate was impacted by hand hygiene compliance, regardless of room configuration, whereas average daily census affected only infants in single-patient rooms. Single-patient rooms did not reduce the rates of MRSA colonization, late-onset sepsis, or death.<\/jats:p><jats:p><jats:italic>Infect Control Hosp Epidemiol<\/jats:italic> 2015;36(10):1173\u20131182<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2015.144","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T05:58:55Z","timestamp":1435211935000},"page":"1173-1182","source":"Crossref","is-referenced-by-count":28,"title":["Impact of Neonatal Intensive Care Bed Configuration on Rates of Late-Onset Bacterial Sepsis and Methicillin-Resistant <i>Staphylococcus aureus<\/i> Colonization"],"prefix":"10.1017","volume":"36","author":[{"given":"Samuel","family":"Julian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carey-Ann D.","family":"Burnham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Sellenriek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Shannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Hamvas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip I.","family":"Tarr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara B.","family":"Warner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,6,25]]},"reference":[{"key":"S0899823X15001440_ref10","unstructured":"National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development. 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