{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:40:20Z","timestamp":1790642420506,"version":"4.1.0"},"reference-count":38,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T00:00:00Z","timestamp":1437350400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec id=\"S0899823X15001671_abs1\" sec-type=\"general\"><jats:title>OBJECTIVE<\/jats:title><jats:p>To describe and compare the mortality associated with nosocomial pneumonia due to<jats:italic>Pseudomonas aeruginosa<\/jats:italic>(<jats:italic>Pa<\/jats:italic>-NP) according to pneumonia classification (community-onset pneumonia [COP], hospital-acquired pneumonia [(HAP], and ventilator-associated pneumonia [VAP]).<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X15001671_abs2\" sec-type=\"general\"><jats:title>DESIGN<\/jats:title><jats:p>We conducted a retrospective cohort study of adults with<jats:italic>Pa<\/jats:italic>-NP. We compared mortality for<jats:italic>Pa<\/jats:italic>-NP among patients with COP, HAP, and VAP and used logistic regression to identify risk factors for hospital mortality and inappropriate initial antibiotic therapy (IIAT).<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X15001671_abs3\" sec-type=\"general\"><jats:title>SETTING<\/jats:title><jats:p>Twelve acute care hospitals in 5 countries (United States, 3; France, 2; Germany, 2; Italy, 2; and Spain, 3).<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X15001671_abs4\" sec-type=\"general\"><jats:title>PATIENTS\/PARTICIPANTS<\/jats:title><jats:p>A total of 742 patients with<jats:italic>Pa<\/jats:italic>-NP.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X15001671_abs5\" sec-type=\"results\"><jats:title>RESULTS<\/jats:title><jats:p>Hospital mortality was greater for those with VAP (41.9%) and HAP (40.1%) compared with COP (24.5%) (<jats:italic>P<\/jats:italic>&lt;.001). In multivariate analyses, independent predictors of hospital mortality differed by pneumonia classification (COP: need for mechanical ventilation and intensive care; HAP: multidrug-resistant isolate; VAP: IIAT, increasing age, increasing Charlson comorbidity score, bacteremia, and use of vasopressors). Presence of multidrug resistance was identified as an independent predictor of IIAT for patients with COP and HAP, whereas recent antibiotic administration was protective in patients with VAP.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X15001671_abs6\" sec-type=\"conclusions\"><jats:title>CONCLUSIONS<\/jats:title><jats:p>Among patients with<jats:italic>Pa<\/jats:italic>-NP, pneumonia classification identified patients with different risks for hospital mortality. Specific risk factors for hospital mortality also differed by pneumonia classification and multidrug resistance appeared to be an important risk factor for IIAT. These findings suggest that pneumonia classification for<jats:italic>P. aeruginosa<\/jats:italic>identifies patients with different mortality risks and specific risk factors for outcome and IIAT.<\/jats:p><jats:p><jats:italic>Infect Control Hosp Epidemiol<\/jats:italic>2015;36(10):1190\u20131197<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2015.167","type":"journal-article","created":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T08:48:24Z","timestamp":1437382104000},"page":"1190-1197","source":"Crossref","is-referenced-by-count":46,"title":["<i>Pseudomonas aeruginosa<\/i>Nosocomial Pneumonia: Impact of Pneumonia Classification"],"prefix":"10.1017","volume":"36","author":[{"given":"Scott T.","family":"Micek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marin 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