{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:53:39Z","timestamp":1777712019180,"version":"3.51.4"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2015,8,26]],"date-time":"2015-08-26T00:00:00Z","timestamp":1440547200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec id=\"S0899823X15002020_abs1\" sec-type=\"general\"><jats:title>OBJECTIVE<\/jats:title><jats:p>To determine whether real-time availability of rapid molecular results of <jats:italic>Staphylococcus aureus<\/jats:italic> would impact emergency department clinician antimicrobial selection for adults with cutaneous abscesses.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X15002020_abs2\" sec-type=\"general\"><jats:title>DESIGN<\/jats:title><jats:p>We performed a prospective, randomized controlled trial comparing a rapid molecular test with standard of care culture-based testing. Follow-up telephone calls were made at between 2 and 7 days, 1 month, and 3 months after discharge.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X15002020_abs3\" sec-type=\"general\"><jats:title>SETTING<\/jats:title><jats:p>Two urban, academic emergency departments.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X15002020_abs4\" sec-type=\"general\"><jats:title>PATIENTS<\/jats:title><jats:p>Patients at least 18 years old presenting with a chief complaint of abscess, cellulitis, or insect bite and receiving incision and drainage were eligible. Seven hundred seventy-eight people were assessed for eligibility and 252 met eligibility criteria.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X15002020_abs5\" sec-type=\"methods\"><jats:title>METHODS<\/jats:title><jats:p>Clinician antibiotic selection and clinical outcomes were evaluated. An ad hoc outcome of test performance was performed.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X15002020_abs6\" sec-type=\"results\"><jats:title>RESULTS<\/jats:title><jats:p>We enrolled 252 patients and 126 were randomized to receive the rapid test. Methicillin-susceptible <jats:italic>S. aureus<\/jats:italic>\u2013positive patients receiving rapid test results were prescribed beta-lactams more often than controls (absolute difference, 14.5% [95% CI, 1.1%\u201330.1%]) whereas methicillin-resistant <jats:italic>S. aureus<\/jats:italic>\u2013positive patients receiving rapid test results were more often prescribed anti\u2013methicillin-resistant <jats:italic>S. aureus<\/jats:italic> antibiotics (absolute difference, 21.5% [95% CI, 10.1%\u201333.0%]). There were no significant differences between the 2 groups in 1-week or 3-month clinical outcomes.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X15002020_abs7\" sec-type=\"conclusion\"><jats:title>CONCLUSION<\/jats:title><jats:p>Availability of rapid molecular test results after incision and drainage was associated with more-targeted antibiotic selection.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X15002020_abs8\" sec-type=\"general\"><jats:title>TRIAL REGISTRATION<\/jats:title><jats:p><jats:uri xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:type=\"simple\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:uri> Identifier: NCT01523899<\/jats:p><jats:p><jats:italic>Infect. Control Hosp. Epidemiol.<\/jats:italic> 2015;36(12):1423\u20131430<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2015.202","type":"journal-article","created":{"date-parts":[[2015,8,26]],"date-time":"2015-08-26T04:32:30Z","timestamp":1440563550000},"page":"1423-1430","source":"Crossref","is-referenced-by-count":21,"title":["A Randomized Clinical Trial Comparing Use of Rapid Molecular Testing for <i>Staphylococcus aureus<\/i> for Patients With Cutaneous Abscesses in the Emergency Department With Standard of Care"],"prefix":"10.1017","volume":"36","author":[{"given":"Larissa S.","family":"May","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard E.","family":"Rothman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loren G.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Zocchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Zatorski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea F.","family":"Dugas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chelsea E.","family":"Ware","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne A.","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,8,26]]},"reference":[{"key":"S0899823X15002020_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-008-0503-9"},{"key":"S0899823X15002020_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2010.11.011"},{"key":"S0899823X15002020_ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055356"},{"key":"S0899823X15002020_ref12","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.5.601"},{"key":"S0899823X15002020_ref13","first-page":"921","article-title":"Clostridium difficile\u2013associated diarrhea","volume":"71","author":"Schroeder","year":"2005","journal-title":"Am Fam Physician"},{"key":"S0899823X15002020_ref14","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-200194080-00014"},{"key":"S0899823X15002020_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2011.01.027"},{"key":"S0899823X15002020_ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03210.x"},{"key":"S0899823X15002020_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2010.11.033"},{"key":"S0899823X15002020_ref5","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01884-08"},{"key":"S0899823X15002020_ref1","doi-asserted-by":"crossref","first-page":"S397","DOI":"10.1093\/cid\/cir153","article-title":"Infectious Diseases Society of America (IDSA). 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