{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T08:41:28Z","timestamp":1781599288601,"version":"3.54.5"},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T00:00:00Z","timestamp":1452470400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec id=\"S0899823X15003104_abs1\" sec-type=\"general\">\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>\n                      To study the effect of discontinuation of systematic surveillance for vancomycin-resistant\n                      <jats:italic>Enterococcus<\/jats:italic>\n                      (VRE) and contact isolation of colonized patients on the incidence of VRE bacteremia\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X15003104_abs2\" sec-type=\"general\">\n                    <jats:title>SETTING<\/jats:title>\n                    <jats:p>A hematology-oncology unit with high prevalence of VRE colonization characterized by predominantly sporadic molecular epidemiology<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X15003104_abs3\" sec-type=\"general\">\n                    <jats:title>PARTICIPANTS<\/jats:title>\n                    <jats:p>Inpatients with hematologic malignancies and recipients of hematopoietic stem cell transplantation<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X15003104_abs4\" sec-type=\"methods\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      The incidence of VRE bacteremia was measured prospectively during 2 different 3-year time periods; the first during active VRE surveillance and contact precautions and the second after discontinuation of these policies. We assessed the collateral impact of this policy change on the incidence of bacteremia due to methicillin-resistant\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      (MRSA) and\n                      <jats:italic>Clostridium difficile<\/jats:italic>\n                      infection even though we maintained contact precautions for these organisms. Incidence of infectious events was measured as number of events per 1,000 patients days per month. Time series analysis was used to evaluate trends.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X15003104_abs5\" sec-type=\"results\">\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The incidence of VRE bacteremia remained stable after discontinuation of VRE surveillance and contact precautions. The incidence of MRSA bacteremia and\n                      <jats:italic>Clostridium difficile<\/jats:italic>\n                      infection for which we continued contact precautions also remained stable. Aggregated antibiotic utilization and nursing hours per patient days were similar between the 2 study periods.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X15003104_abs6\" sec-type=\"conclusion\">\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Active surveillance and contact precautions for VRE colonization did not appear to prevent VRE bacteremia in patients with hematologic malignancies and recipients of hematopoietic stem cell transplantation with high prevalence of VRE characterized by predominantly sporadic molecular epidemiology.<\/jats:p>\n                    <jats:p>\n                      <jats:italic>Infect. Control Hosp. Epidemiol.<\/jats:italic>\n                      2016;37(4):398\u2013403\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/ice.2015.310","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T05:28:12Z","timestamp":1452490092000},"page":"398-403","source":"Crossref","is-referenced-by-count":43,"title":["Discontinuation of Systematic Surveillance and Contact Precautions for Vancomycin-Resistant\n                    <i>Enterococcus<\/i>\n                    (VRE) and Its Impact on the Incidence of VRE\n                    <i>faecium<\/i>\n                    Bacteremia in Patients with Hematologic Malignancies"],"prefix":"10.1017","volume":"37","author":[{"given":"Nikolaos G.","family":"Almyroudis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Osawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Samonis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wetzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunice S.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Philip L.","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brahm H.","family":"Segal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,1,11]]},"reference":[{"key":"S0899823X15003104_ref29","doi-asserted-by":"publisher","DOI":"10.1086\/669526"},{"key":"S0899823X15003104_ref21","first-page":"762","article-title":"Transmission of resistant bacteria in intensive care","volume":"365","author":"Almyroudis","year":"2011","journal-title":"N Engl J Med"},{"key":"S0899823X15003104_ref18","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis272"},{"key":"S0899823X15003104_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2010.06.024"},{"key":"S0899823X15003104_ref31","doi-asserted-by":"publisher","DOI":"10.1086\/501623"},{"key":"S0899823X15003104_ref24","doi-asserted-by":"publisher","DOI":"10.1086\/673153"},{"key":"S0899823X15003104_ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198807213190307"},{"key":"S0899823X15003104_ref2","doi-asserted-by":"publisher","DOI":"10.1086\/427512"},{"key":"S0899823X15003104_ref14","doi-asserted-by":"publisher","DOI":"10.1086\/501880"},{"key":"S0899823X15003104_ref32","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.1.326-328.2004"},{"key":"S0899823X15003104_ref6","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing: 13th informational Supplement. 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