{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:19:59Z","timestamp":1785831599507,"version":"3.56.0"},"reference-count":37,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T00:00:00Z","timestamp":1475539200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec id=\"S0899823X16002233_abs1\" sec-type=\"general\"><jats:title>BACKGROUND<\/jats:title><jats:p>Patients are frequently discharged with central venous catheters (CVCs) for home infusion therapy.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X16002233_abs2\" sec-type=\"general\"><jats:title>OBJECTIVE<\/jats:title><jats:p>To study a prospective cohort of patients receiving home infusion therapy to identify environmental and other risk factors for complications.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X16002233_abs3\" sec-type=\"general\"><jats:title>DESIGN<\/jats:title><jats:p>Prospective cohort study between March and December 2015.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X16002233_abs4\" sec-type=\"general\"><jats:title>SETTING<\/jats:title><jats:p>Home infusion therapy after discharge from academic medical centers.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X16002233_abs5\" sec-type=\"general\"><jats:title>PARTICIPANTS<\/jats:title><jats:p>Of 368 eligible patients discharged from 2 academic hospitals to home with peripherally inserted central catheters and tunneled CVCs, 222 consented. Patients remained in the study until 30 days after CVC removal.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X16002233_abs6\" sec-type=\"methods\"><jats:title>METHODS<\/jats:title><jats:p>Patients underwent chart abstraction and monthly telephone surveys while the CVC was in place, focusing on complications and environmental exposures. Multivariable analyses estimated adjusted odds ratios and adjusted incident rate ratios between clinical, demographic, and environmental risk factors and 30-day readmissions or CVC complications.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X16002233_abs7\" sec-type=\"results\"><jats:title>RESULTS<\/jats:title><jats:p>Of 222 patients, total parenteral nutrition was associated with increased 30-day readmissions (adjusted odds ratio, 4.80 [95% CI, 1.51\u201315.21) and CVC complications (adjusted odds ratio, 2.41 [95% CI, 1.09\u20135.33]). Exposure to soil through gardening or yard work was associated with a decreased likelihood of readmissions (adjusted odds ratio, 0.09 [95% CI, 0.01\u20130.74]). Other environmental exposures were not associated with CVC complications.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X16002233_abs8\" sec-type=\"conclusions\"><jats:title>CONCLUSIONS<\/jats:title><jats:p>complications and readmissions were common and associated with the use of total parenteral nutrition. Common environmental exposures (well water, cooking with raw meat, or pets) did not increase the rate of CVC complications, whereas soil exposures were associated with decreased readmissions. Interventions to decrease home CVC complications should focus on total parenteral nutrition patients.<\/jats:p><jats:p><jats:italic>Infect Control Hosp Epidemiol<\/jats:italic> 2016;1\u20138<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2016.223","type":"journal-article","created":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T11:04:00Z","timestamp":1475579040000},"page":"68-75","source":"Crossref","is-referenced-by-count":25,"title":["Environmental Exposures and the Risk of Central Venous Catheter Complications and Readmissions in Home Infusion Therapy Patients"],"prefix":"10.1017","volume":"38","author":[{"given":"Sara C.","family":"Keller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitra","family":"Gavgani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hirsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Adamovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"Hohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Krosche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Cosgrove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trish M.","family":"Perl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,10,4]]},"reference":[{"key":"S0899823X16002233_ref16","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-131-5-199909070-00004"},{"key":"S0899823X16002233_ref8","doi-asserted-by":"publisher","DOI":"10.1177\/0148607111428452"},{"key":"S0899823X16002233_ref7","first-page":"605","article-title":"Central venous catheter complications during home parenteral nutrition: a prospective pilot study of 481 patients with more than 30,000 catheter days","volume":"31","author":"Crispin","year":"2008","journal-title":"Onkologie"},{"key":"S0899823X16002233_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-005-3179-0"},{"key":"S0899823X16002233_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S1553-7250(13)39050-3"},{"key":"S0899823X16002233_ref4","unstructured":"Association of Professionals in Infection Control (APIC). 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