{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:40:39Z","timestamp":1790995239193,"version":"4.1.0"},"reference-count":41,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T00:00:00Z","timestamp":1480291200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec id=\"S0899823X16002749_abs1\" sec-type=\"general\"><jats:title>OBJECTIVE<\/jats:title><jats:p>To determine the origin of grouped cases of <jats:italic>Pneumocystis<\/jats:italic> pneumonia in solid-organ transplant recipients at our institution.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X16002749_abs2\" sec-type=\"general\"><jats:title>DESIGN<\/jats:title><jats:p>A case series with clinical examinations, genotyping, and an epidemiological survey.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X16002749_abs3\" sec-type=\"general\"><jats:title>SETTING<\/jats:title><jats:p>A university hospital in France.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X16002749_abs4\" sec-type=\"general\"><jats:title>PATIENTS<\/jats:title><jats:p>We report 12 solid-organ transplant recipients with successive cases of <jats:italic>Pneumocystis<\/jats:italic> pneumonia that occurred over 3 years; 10 of these cases occurred in a single year.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X16002749_abs5\" sec-type=\"methods\"><jats:title>METHODS<\/jats:title><jats:p>We used molecular typing of <jats:italic>P. jirovecii<\/jats:italic> strains by multilocus sequence typing and clinical epidemiological survey to determine potential dates and places of transmission.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X16002749_abs6\" sec-type=\"results\"><jats:title>RESULTS<\/jats:title><jats:p>Between May 2014 and March 2015, 10 solid-organ transplant recipients (5 kidney transplants, 4 heart transplants, and 1 lung transplant) presented with <jats:italic>Pneumocystis<\/jats:italic> pneumonia. Molecular genotyping revealed the same <jats:italic>P. jirovecii<\/jats:italic> strain in at least 6 patients. This <jats:italic>Pneumocystis<\/jats:italic> strain was not identified in control patients (ie, nontransplant patients presenting with pulmonary pneumocystosis) during this period. The epidemiological survey guided by sequencing results provided information on the probable or possible dates and places of contamination for 5 of these patients. The mobile infectious diseases unit played a coordination role in the clinical management (adaptation of the local guidelines) and epidemiological survey.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X16002749_abs7\" sec-type=\"conclusion\"><jats:title>CONCLUSION<\/jats:title><jats:p>Our cardiac and kidney transplant units experienced grouped cases of pulmonary pneumocystosis. Genotyping and epidemiological surveying results suggested interhuman contamination, which was quickly eliminated thanks to multidisciplinary coordination.<\/jats:p><jats:p><jats:italic>Infect Control Hosp Epidemiol<\/jats:italic> 2017;38:179\u2013185<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2016.274","type":"journal-article","created":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T01:58:35Z","timestamp":1480298315000},"page":"179-185","source":"Crossref","is-referenced-by-count":7,"title":["Grouped Cases of Pulmonary Pneumocystosis After Solid Organ Transplantation: Advantages of Coordination by an Infectious Diseases Unit for Overall Management and Epidemiological Monitoring"],"prefix":"10.1017","volume":"38","author":[{"given":"Claire","family":"Wintenberger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Maubon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Charpentier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Rendu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Pavese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Augier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Malvezzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boubou","family":"Camara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Reine","family":"Mallaret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Bouillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Epaulard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,11,28]]},"reference":[{"key":"S0899823X16002749_ref38","first-page":"CD005590","article-title":"Prophylaxis for Pneumocystis pneumonia (PCP) in non-HIV immunocompromised patients","author":"Green","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"S0899823X16002749_ref34","unstructured":"Program schedule. 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