{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T09:58:24Z","timestamp":1783850304782,"version":"3.55.0"},"reference-count":40,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T00:00:00Z","timestamp":1482105600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec id=\"S0899823X1600307X_abs1\" sec-type=\"general\"><jats:title>OBJECTIVE<\/jats:title><jats:p>To determine risk factors for the development of surgical site infections (SSIs) in neurosurgery patients undergoing spinal fusion.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X1600307X_abs2\" sec-type=\"general\"><jats:title>DESIGN<\/jats:title><jats:p>Retrospective case-control study.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X1600307X_abs3\" sec-type=\"general\"><jats:title>SETTING<\/jats:title><jats:p>Large, academic, quaternary care center.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X1600307X_abs4\" sec-type=\"general\"><jats:title>PATIENTS<\/jats:title><jats:p>The study population included all neurosurgery patients who underwent spinal fusion between August 1, 2009, and August 31, 2013. Cases were defined as patients in the study cohort who developed an SSI. Controls were patients in the study cohort who did not develop an SSI.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X1600307X_abs5\" sec-type=\"methods\"><jats:title>METHODS<\/jats:title><jats:p>To achieve 80% power with an ability to detect an odds ratio (OR) of 2, we performed an unmatched case-control study with equal numbers of cases and controls.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X1600307X_abs6\" sec-type=\"results\"><jats:title>RESULTS<\/jats:title><jats:p>During the study period, 5,473 spinal fusion procedures were performed by neurosurgeons in our hospital. With 161 SSIs recorded during the study period, the incidence of SSIs associated with these procedures was 2.94%. While anterior surgical approach was found to be a protective factor (OR, 0.20; 95% confidence interval [CI], 0.08\u20130.52), duration of procedure (OR, 1.58; 95% CI, 1.29\u20131.93), American Society of Anesthesiologists score of 3 or 4 (OR, 1.79; 95% CI, 1.00\u20133.18), and hospitalization within the prior 30 days (OR, 5.8; 95% CI, 1.37\u201324.57) were found in multivariate analysis to be independent predictors of SSI following spinal fusion. Prior methicillin-resistant<jats:italic>Staphylococcus aureus<\/jats:italic>(MRSA) nares colonization was highly associated with odds 20 times higher of SSI following spinal fusion (OR, 20.30; 95% CI, 4.64\u20138.78).<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X1600307X_abs7\" sec-type=\"conclusions\"><jats:title>CONCLUSIONS<\/jats:title><jats:p>In additional to nonmodifiable risk factors, prior colonization with MRSA is a modifiable risk factor very strongly associated with development of SSI following spinal fusion.<\/jats:p><jats:p><jats:italic>Infect Control Hosp Epidemiol<\/jats:italic>2017;38:348\u2013352<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2016.307","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T03:08:39Z","timestamp":1482116919000},"page":"340-347","source":"Crossref","is-referenced-by-count":18,"title":["Risk Factors for Surgical Site Infections Following Neurosurgical Spinal Fusion Operations: A Case Control Study"],"prefix":"10.1017","volume":"38","author":[{"given":"Thomas L.","family":"Walsh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley M.","family":"Querry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"McCool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison L.","family":"Galdys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen A.","family":"Shutt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa I.","family":"Saul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlene A.","family":"Muto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,12,19]]},"reference":[{"key":"S0899823X1600307X_ref18","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.F.01515"},{"key":"S0899823X1600307X_ref28","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199611150-00018"},{"key":"S0899823X1600307X_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2008.12.010"},{"key":"S0899823X1600307X_ref26","first-page":"124","article-title":"Predisposing factors for infection in spine surgery: a survey of 850 spinal procedures","volume":"11","author":"Wilmmer","year":"1998","journal-title":"J Spinal Disord"},{"key":"S0899823X1600307X_ref17","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181974be7"},{"key":"S0899823X1600307X_ref5","unstructured":"Healthcare Cost and Utilization Project: Statistics on hospital stays, 2013. 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