{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:15:15Z","timestamp":1767705315616},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T00:00:00Z","timestamp":1460073600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec id=\"S0899823X16000817_abs1\" sec-type=\"general\"><jats:title>OBJECTIVE<\/jats:title><jats:p>Invasive aspergillosis (IA) is a rare but severe infection caused by <jats:italic>Aspergillus<\/jats:italic> spp. that often develops in immunocompromised patients. Lethality remains high in this population. Therefore, preventive strategies are of key importance. The impact of a mobile air decontamination system (Plasmair, AirInSpace, Montigny-le-Bretonneux, France) on the incidence of IA in neutropenic patients was evaluated in this study.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X16000817_abs2\" sec-type=\"general\"><jats:title>DESIGN<\/jats:title><jats:p>Retrospective cohort study<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X16000817_abs3\" sec-type=\"methods\"><jats:title>METHODS<\/jats:title><jats:p>Patients with chemotherapy-induced neutropenia lasting 7 days or more were included over a 2-year period. Cases of IA were confirmed using the revised European Organization for Research and Treatment of Cancer (EORTC) criteria. We took advantage of a partial installation of Plasmair systems in the hematology intensive care unit during this period to compare patients treated in Plasmair-equipped versus non-equipped rooms. Patients were assigned to Plasmair-equipped or non-equipped rooms depending only on bed availability. Differences in IA incidence in both groups were compared using Fisher\u2019s exact test, and a multivariate analysis was performed to take into account potential confounding factors.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X16000817_abs4\" sec-type=\"results\"><jats:title>RESULTS<\/jats:title><jats:p>Data from 156 evaluable patients were available. Both groups were homogenous in terms of age, gender, hematological diagnosis, duration of neutropenia, and prophylaxis. A total of 11 cases of probable IA were diagnosed: 10 in patients in non-equipped rooms and only 1 patient in a Plasmair-equipped room. The odds of developing IA were much lower for patients hospitalized in Plasmair-equipped rooms than for patients in non-equipped rooms (P=.02; odds ratio [OR] =0.11; 95% confidence interval [CI], 0.00\u20130.84).<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X16000817_abs5\" sec-type=\"conclusion\"><jats:title>CONCLUSION<\/jats:title><jats:p>In this study, Plasmair demonstrated a major impact in reducing the incidence of IA in neutropenic patients with hematologic malignancies.<\/jats:p><jats:p><jats:italic>Infect Control Hosp Epidemiol<\/jats:italic> 2016;37:845\u2013851<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2016.81","type":"journal-article","created":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T06:43:55Z","timestamp":1460443435000},"page":"845-851","source":"Crossref","is-referenced-by-count":7,"title":["The Plasmair Decontamination System Is Protective Against Invasive Aspergillosis in Neutropenic Patients"],"prefix":"10.1017","volume":"37","author":[{"given":"Marie-Paule","family":"Fernandez-Gerlinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Sophie","family":"Jannot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Rigaudeau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliette","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Odile","family":"Eloy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Mignon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Farhat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Castaigne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Merrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Rousselot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2016,4,8]]},"reference":[{"key":"S0899823X16000817_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2012.01.003"},{"key":"S0899823X16000817_ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2001.tb00008.x"},{"key":"S0899823X16000817_ref4","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/164.5.998"},{"key":"S0899823X16000817_ref18","doi-asserted-by":"publisher","DOI":"10.1086\/521378"},{"key":"S0899823X16000817_ref15","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.5.2184-2186.2003"},{"key":"S0899823X16000817_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2009.09.014"},{"key":"S0899823X16000817_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2007.02.006"},{"key":"S0899823X16000817_ref8","doi-asserted-by":"publisher","DOI":"10.1086\/502101"},{"key":"S0899823X16000817_ref6","doi-asserted-by":"publisher","DOI":"10.1053\/jhin.2001.0998"},{"key":"S0899823X16000817_ref16","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"S0899823X16000817_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2012.08.006"},{"key":"S0899823X16000817_ref2","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/sj.leu.2403674","article-title":"Risk factors for invasive aspergillosis in neutropenic patients with hematologic malignancies","volume":"19","author":"Muhlemann","year":"2005","journal-title":"Leukemia"},{"key":"S0899823X16000817_ref7","doi-asserted-by":"publisher","DOI":"10.1086\/501661"},{"key":"S0899823X16000817_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2006.10.013"},{"key":"S0899823X16000817_ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0808853"},{"key":"S0899823X16000817_ref1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-3-345"},{"key":"S0899823X16000817_ref12","doi-asserted-by":"publisher","DOI":"10.1086\/520733"},{"key":"S0899823X16000817_ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2006.01499.x"},{"key":"S0899823X16000817_ref11","doi-asserted-by":"publisher","DOI":"10.1086\/508840"},{"key":"S0899823X16000817_ref21","first-page":"79","article-title":"The epidemiological surveillance network for nosocomial invasive aspergillosis of the Assistance Publique-Hopitaux de Paris [In French]","volume":"146","author":"Bocquet","year":"1995","journal-title":"Ann Med Interne"},{"key":"S0899823X16000817_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2007.09.013"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X16000817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T22:55:25Z","timestamp":1555628125000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X16000817\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,8]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S0899823X16000817"],"URL":"https:\/\/doi.org\/10.1017\/ice.2016.81","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,8]]}}}