{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T17:10:07Z","timestamp":1750785007942,"version":"3.41.0"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T00:00:00Z","timestamp":1500508800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec id=\"S0899823X17001386_abs1\" sec-type=\"general\"><jats:title>OBJECTIVE<\/jats:title><jats:p>While a direct relation between hospital construction and concomitant infection rates has been clearly established, few data are available regarding the environmental decontamination effects of renovation in which surfaces are replaced and regarding subsequent infection incidence.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X17001386_abs2\" sec-type=\"general\"><jats:title>DESIGN<\/jats:title><jats:p>Retrospective clinical study with vancomycin-resistant<jats:italic>Enterococcus<\/jats:italic>(VRE) molecular strain typing and environmental cultures.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X17001386_abs3\" sec-type=\"general\"><jats:title>SETTING<\/jats:title><jats:p>A regional referral center for acute leukemia and hematopoietic stem-cell transplantation.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X17001386_abs4\" sec-type=\"general\"><jats:title>PATIENTS<\/jats:title><jats:p>Overall, 536 consecutive hospital admissions for newly diagnosed acute leukemia or a first autologous or allogeneic stem-cell transplantation were reviewed.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X17001386_abs5\" sec-type=\"general\"><jats:title>INTERVENTION<\/jats:title><jats:p>During 2009\u20132010, our unit underwent complete remodeling including replacement of all surfaces. We assessed the effects of this construction on the incidence of hospital-acquired VRE colonization before, during, and after the renovation.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X17001386_abs6\" sec-type=\"results\"><jats:title>RESULTS<\/jats:title><jats:p>We observed a sharp decrease in VRE colonization rates (hazard ratio, &lt;0.23; 95% confidence interval, 0.18\u20130.44;<jats:italic>P<\/jats:italic>&lt;.0001) during the first year after the renovation, with a return to near baseline rates thereafter. The known risk factors for VRE colonization appeared to be stable over the study interval. Environmental cultures outside of patient rooms revealed several contaminated areas that are commonly touched by unit personnel. Multilocus sequence typing of VRE isolates that were cryopreserved over the study interval showed that dominant strains prior to construction disappeared and were replaced by other strains after the renovation.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X17001386_abs7\" sec-type=\"conclusions\"><jats:title>CONCLUSIONS<\/jats:title><jats:p>Unit reconstruction interrupted endemic transmission of VRE, which resumed with novel strains upon reopening. Contamination of environmental surfaces and shared equipment may play an important role in endemic transmission of VRE.<\/jats:p><jats:p><jats:italic>Infect Control Hosp Epidemiol<\/jats:italic>2017;38:1055\u20131061<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2017.138","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T05:55:16Z","timestamp":1500530116000},"page":"1055-1061","source":"Crossref","is-referenced-by-count":3,"title":["Decrease in Vancomycin-Resistant<i>Enterococcus<\/i>Colonization After Extensive Renovation of a Unit Dedicated to the Treatment of Hematologic Malignancies and Hematopoietic Stem-Cell Transplantation"],"prefix":"10.1017","volume":"38","author":[{"given":"Clyde D.","family":"Ford","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela A.","family":"Gazdik Stofer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Coombs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bert K.","family":"Lopansri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon J.","family":"Webb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Motyckova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Finn Bo","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2017,7,20]]},"reference":[{"key":"S0899823X17001386_ref18","first-page":"1571","article-title":"Universal glove and gown use and acquisition of antibiotic-resistant bacteria in the ICU: a randomized trial","volume":"310","author":"Harris","year":"2013","journal-title":"JAMA"},{"key":"S0899823X17001386_ref17","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.10.1127"},{"key":"S0899823X17001386_ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.16.1905"},{"key":"S0899823X17001386_ref6","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"Series B 57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc"},{"key":"S0899823X17001386_ref14","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-6-130"},{"key":"S0899823X17001386_ref7","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2014.3"},{"key":"S0899823X17001386_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.11.017"},{"key":"S0899823X17001386_ref3","doi-asserted-by":"publisher","DOI":"10.1086\/527394"},{"key":"S0899823X17001386_ref10","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.469"},{"key":"S0899823X17001386_ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1985.01390260077011"},{"key":"S0899823X17001386_ref1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ297"},{"key":"S0899823X17001386_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2012.01.031"},{"key":"S0899823X17001386_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2016.03.044"},{"key":"S0899823X17001386_ref13","doi-asserted-by":"publisher","DOI":"10.1086\/503845"},{"key":"S0899823X17001386_ref5","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.6.1963-1971.2002"},{"key":"S0899823X17001386_ref2","first-page":"160","article-title":"Bacillus species pseudo-outbreak: construction works and collateral damage","volume":"56","author":"Boix-Palop","year":"2017","journal-title":"J Hosp Infect"},{"key":"S0899823X17001386_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2005.11.011"},{"key":"S0899823X17001386_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2016.10.017"},{"key":"S0899823X17001386_ref19","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-125-6-199609150-00004"}],"container-title":["Infection Control &amp; 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