{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T01:24:57Z","timestamp":1786497897749,"version":"build-2736575974"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T00:00:00Z","timestamp":1486339200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec id=\"S0899823X17000046_abs1\" sec-type=\"general\"><jats:title>OBJECTIVE<\/jats:title><jats:p>To describe the effect of universal methicillin-resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) decolonization therapy in a large intensive care unit (ICU) on the rates of MRSA cases and acquisitions in a UK hospital.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X17000046_abs2\" sec-type=\"general\"><jats:title>DESIGN<\/jats:title><jats:p>Descriptive study.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X17000046_abs3\" sec-type=\"general\"><jats:title>SETTING<\/jats:title><jats:p>University Hospitals Birmingham (UHB) NHS Foundation Trust is a tertiary referral teaching hospital in Birmingham, United Kingdom, that provides clinical services to nearly 1 million patients every year.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X17000046_abs4\" sec-type=\"methods\"><jats:title>METHODS<\/jats:title><jats:p>A break-point time series analysis and kernel regression models were used to detect significant changes in the cumulative monthly numbers of MRSA bacteremia cases and acquisitions from April 2013 to August 2016 across the UHB system.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X17000046_abs5\" sec-type=\"results\"><jats:title>RESULTS<\/jats:title><jats:p>Prior to 2014, all ICU patients at UHB received universal MRSA decolonization therapy. In August 2014, UHB discontinued the use of universal decolonization due to published reports in the United Kingdom detailing the limited usefulness and cost-effectiveness of such an intervention. Break-point time series analysis of MRSA acquisition and bacteremia data indicated that break points were associated with the discontinuation and subsequent reintroduction of universal decolonization. Kernel regression models indicated a significant increase (<jats:italic>P<\/jats:italic>&lt;.001) in MRSA acquisitions and bacteremia cases across UHB during the period without universal decolonization.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X17000046_abs6\" sec-type=\"conclusion\"><jats:title>CONCLUSION<\/jats:title><jats:p>We suggest that routine decolonization for MRSA in a large ICU setting is an effective strategy to reduce the spread and incidence of MRSA across the whole hospital.<\/jats:p><jats:p><jats:italic>Infect Control Hosp Epidemiol<\/jats:italic> 2017;38:430\u2013435<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2017.4","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T02:29:10Z","timestamp":1486348150000},"page":"430-435","source":"Crossref","is-referenced-by-count":16,"title":["The Effect of Universal Decolonization With Screening in Critical Care to Reduce MRSA Across an Entire Hospital"],"prefix":"10.1017","volume":"38","author":[{"given":"Craig W.","family":"Bradley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martyn A. C.","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark I.","family":"Garvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2017,2,6]]},"reference":[{"key":"S0899823X17000046_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2010.03.006"},{"key":"S0899823X17000046_ref19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1207290"},{"key":"S0899823X17000046_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2012.12.018"},{"key":"S0899823X17000046_ref18","unstructured":"R version 3.3.1 (2016-06-21)\u2014\u201cBug in Your Hair.\u201d The R Foundation for Statistical Computing website. https:\/\/www.r-project.org\/. Published 2016. 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The national one-week prevalence audit of universal meticillin-resistant Staphylococcus aureus (MRSA) admission screening 2012. PLoS one 2013;12:e74219.","DOI":"10.1371\/journal.pone.0074219"},{"key":"S0899823X17000046_ref13","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000711"},{"key":"S0899823X17000046_ref4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5694"},{"key":"S0899823X17000046_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2016.09.013"},{"key":"S0899823X17000046_ref12","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2014.12"},{"key":"S0899823X17000046_ref16","unstructured":"Guidance on the reporting and monitoring arrangements and post infection review process for MRSA bloodstream infections from April 2014. Patient Safety Domain, NHS England website. https:\/\/www.england.nhs.uk\/patientsafety\/wp-content\/uploads\/sites\/32\/2014\/02\/post-inf-guidance2.pdf. Published 2014. Accessed January 5, 2017."},{"key":"S0899823X17000046_ref6","doi-asserted-by":"publisher","DOI":"10.1086\/597550"},{"key":"S0899823X17000046_ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808939"},{"key":"S0899823X17000046_ref11","doi-asserted-by":"publisher","DOI":"10.1086\/660875"},{"key":"S0899823X17000046_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)70193-8"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X17000046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T21:55:41Z","timestamp":1555538141000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X17000046\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,6]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S0899823X17000046"],"URL":"https:\/\/doi.org\/10.1017\/ice.2017.4","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,6]]}}}