{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:14:31Z","timestamp":1790900071358,"version":"4.1.0"},"reference-count":36,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T00:00:00Z","timestamp":1532390400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0899823X18001514_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>To determine the efficacy in eradicating <jats:italic>Staphylococcus aureus<\/jats:italic> (SA) carriage of a 5-day preoperative decolonization bundle compared to 2 disinfectant soap showers, with both regimens self-administered at home.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X18001514_abs2\" sec-type=\"general\"><jats:title>Design<\/jats:title><jats:p>Open label, single-center, randomized clinical trial.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X18001514_abs3\" sec-type=\"general\"><jats:title>Setting<\/jats:title><jats:p>Ambulatory orthopedic, urologic, neurologic, colorectal, cardiovascular, and general surgery clinics at a tertiary-care referral center in the United States.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X18001514_abs4\" sec-type=\"general\"><jats:title>Participants<\/jats:title><jats:p>Patients at the University of Minnesota Medical Center planning to have elective surgery and not on antibiotics.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X18001514_abs5\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Consenting participants were screened for SA colonization using nasal, throat, axillary, and perianal swab cultures. Carriers of SA were randomized, stratified by methicillin resistance status, to a decolonization bundle group (5 days of nasal mupirocin, chlorhexidine gluconate [CHG] bathing, and CHG mouthwash) or control group (2 preoperative showers with antiseptic soap). Colonization status was reassessed preoperatively. The primary endpoint was absence of SA at all 4 screened body sites.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X18001514_abs6\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Of 427 participants screened between August 31, 2011, and August 9, 2016, 127 participants (29.7%) were SA carriers. Of these, 121 were randomized and 110 were eligible for efficacy analysis (57 decolonization bundle group, 53 control group). Overall, 90% of evaluable participants had methicillin-susceptible SA strains. Eradication of SA at all body sites was achieved for 41 of 57 participants (71.9%) in the decolonization bundle group and for 13 of 53 participants (24.5%) in the control group, a difference of 47.4% (95% confidence interval [CI], 29.1%\u201365.7%; <jats:italic>P<\/jats:italic>&lt;.0001).<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X18001514_abs7\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>An outpatient preoperative antiseptic decolonization bundle aimed at 4 body sites was significantly more effective in eradicating SA than the usual disinfectant showers (ie, the control).<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X18001514_abs8\" sec-type=\"general\"><jats:title>Trial Registration<\/jats:title><jats:p>ClinicalTrials.gov identifier: NCT02182115<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2018.151","type":"journal-article","created":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T04:49:02Z","timestamp":1532407742000},"page":"1049-1057","source":"Crossref","is-referenced-by-count":20,"title":["Randomized controlled trial of a self-administered five-day antiseptic bundle versus usual disinfectant soap showers for preoperative eradication of <i>Staphylococcus aureus<\/i> colonization"],"prefix":"10.1017","volume":"39","author":[{"given":"Susan E.","family":"Kline","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Neaton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Lynfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Ferrieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Kulasingam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayleigh","family":"Dittes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Glennen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selina","family":"Jawahir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kaizer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremiah","family":"Menk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2018,7,24]]},"reference":[{"key":"S0899823X18001514_ref20","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.20.2460"},{"key":"S0899823X18001514_ref35","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01444-16"},{"key":"S0899823X18001514_ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-008-0225-4"},{"key":"S0899823X18001514_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2006.06.010"},{"key":"S0899823X18001514_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2016.12.021"},{"key":"S0899823X18001514_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2016.10.005"},{"key":"S0899823X18001514_ref3","doi-asserted-by":"publisher","DOI":"10.1086\/522186"},{"key":"S0899823X18001514_ref4","doi-asserted-by":"publisher","DOI":"10.1086\/367653"},{"key":"S0899823X18001514_ref2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm480"},{"key":"S0899823X18001514_ref25","unstructured":"Becher K , Skov RL , VonEiff C . 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