{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:40:05Z","timestamp":1791823205122,"version":"4.3.4"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T00:00:00Z","timestamp":1537228800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0899823X18002155_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>To determine the effectiveness of ultraviolet (UV) environmental disinfection system on rates of hospital-acquired vancomycin-resistant enterococcus (VRE) and <jats:italic>Clostridium difficile<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X18002155_abs2\" sec-type=\"general\"><jats:title>Design<\/jats:title><jats:p>Using active surveillance and an interrupted time-series design, hospital-acquired acquisition of VRE and <jats:italic>C. difficile<\/jats:italic> on a bone marrow transplant (BMT) unit were examined before and after implementation of terminal disinfection with UV on all rooms regardless of isolation status of patients. The main outcomes were hospital-based acquisition measured through (1) active surveillance: admission, weekly, and discharge screening for VRE and toxigenic <jats:italic>C. difficile<\/jats:italic> (TCD) and (2) clinical surveillance: incidence of VRE and CDI on the unit.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X18002155_abs3\" sec-type=\"general\"><jats:title>Setting<\/jats:title><jats:p>Bone marrow transplant unit at a tertiary-care cancer center.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X18002155_abs4\" sec-type=\"general\"><jats:title>Participants<\/jats:title><jats:p>Stem cell transplant (SCT) recipients.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X18002155_abs5\" sec-type=\"general\"><jats:title>Intervention<\/jats:title><jats:p>Terminal disinfection of all rooms with UV regardless of isolation status of patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X18002155_abs6\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>During the 20-month study period, 579 patients had 704 admissions to the BMT unit, and 2,160 surveillance tests were performed. No change in level or trend in the incidence of VRE (trend incidence rate ratio [IRR], 0.96; 95% confidence interval [CI], 0.81\u20131.14; level IRR, 1.34; 95% CI, 0.37\u20131.18) or <jats:italic>C. difficile<\/jats:italic> (trend IRR, 1.08; 95% CI, 0.89\u20131.31; level IRR, 0.51; 95% CI, 0.13\u20132.11) was observed after the intervention.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X18002155_abs7\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Utilization of UV disinfection to supplement routine terminal cleaning of rooms was not effective in reducing hospital-acquired VRE and <jats:italic>C. difficile<\/jats:italic> among SCT recipients.<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2018.215","type":"journal-article","created":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T06:03:26Z","timestamp":1537250606000},"page":"1301-1306","source":"Crossref","is-referenced-by-count":26,"title":["Effectiveness of ultraviolet disinfection in reducing hospital-acquired <i>Clostridium difficile<\/i> and vancomycin-resistant <i>Enterococcus<\/i> on a bone marrow transplant unit"],"prefix":"10.1017","volume":"39","author":[{"given":"Jennifer","family":"Brite","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"McMillen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Robilotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoi Yan","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Stell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan K.","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"McKenna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Eagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Montecalvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent","family":"Sepkowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mini","family":"Kamboj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2018,9,18]]},"reference":[{"key":"S0899823X18002155_ref3","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-6-130"},{"key":"S0899823X18002155_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2015.05.003"},{"key":"S0899823X18002155_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2013.12.013"},{"key":"S0899823X18002155_ref5","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-187"},{"key":"S0899823X18002155_ref4","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.6193"},{"key":"S0899823X18002155_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2015.07.029"},{"key":"S0899823X18002155_ref15","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2015.237"},{"key":"S0899823X18002155_ref1","doi-asserted-by":"publisher","DOI":"10.1086\/527394"},{"key":"S0899823X18002155_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2013.02.010"},{"key":"S0899823X18002155_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2007.10.007"},{"key":"S0899823X18002155_ref21","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2016.222"},{"key":"S0899823X18002155_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2015.03.027"},{"key":"S0899823X18002155_ref6","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-10-197"},{"key":"S0899823X18002155_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2016.04.022"},{"key":"S0899823X18002155_ref13","first-page":"172","article-title":"Impact of a multi-hospital intervention utilising screening, hand hygiene education and pulsed xenon ultraviolet (PX-UV) on the rate of hospital associated meticillin resistant Staphylococcus aureus infection. 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