{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:20:30Z","timestamp":1791642030077,"version":"4.3.4"},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T00:00:00Z","timestamp":1542153600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2019,1]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n Hospital environmental surfaces are frequently contaminated by microorganisms. However, the causal mechanism of bacterial contamination of the environment as a source of transmission is still debated. This prospective study was performed to characterize the nature of multidrug-resistant organism (MDRO) transmission between the environment and patients using standard microbiological and molecular techniques.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Prospective cohort study at 2 academic medical centers.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n \n A prospective multicenter study to characterize the nature of bacterial transfer events between patients and environmental surfaces in rooms that previously housed patients with 1 of 4 \u2018marker\u2019 MDROs: methicillin-resistant\n Staphylococcus aureus<\/jats:italic>\n , vancomycin-resistant enterococci,\n Clostridium difficile<\/jats:italic>\n , and MDR\n Acinetobacter baumannii<\/jats:italic>\n . Environmental and patient microbiological samples were obtained on admission into a freshly disinfected inpatient room. Repeat samples from room surfaces and patients were taken on days 3 and 7 and each week the patient stayed in the same room. The bacterial identity, antibiotic susceptibility, and molecular sequences were compared between organisms found in the environment samples and patient sources.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n We enrolled 80 patient\u2013room admissions; 9 of these patients (11.3%) were asymptomatically colonized with MDROs at study entry. Hospital room surfaces were contaminated with MDROs despite terminal disinfection in 44 cases (55%). Microbiological Bacterial Transfer events either to the patient, the environment, or both occurred in 12 patient encounters (18.5%) from the microbiologically evaluable cohort.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Microbiological Bacterial Transfer events between patients and the environment were observed in 18.5% of patient encounters and occurred early in the admission. This study suggests that research on prevention methods beyond the standard practice of room disinfection at the end of a patient\u2019s stay is needed to better prevent acquisition of MDROs through the environment.<\/jats:p>\n <\/jats:sec>","DOI":"10.1017\/ice.2018.275","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T02:03:55Z","timestamp":1542161035000},"page":"47-52","source":"Crossref","is-referenced-by-count":69,"title":["A prospective study of transmission of Multidrug-Resistant Organisms (MDROs) between environmental sites and hospitalized patients\u2014the TransFER study"],"prefix":"10.1017","volume":"40","author":[{"given":"Luke F.","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren P.","family":"Knelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria F.","family":"Gergen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga M.","family":"Better","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradly P.","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Rutala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Sexton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deverick J.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the CDC Prevention Epicenters Program","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2018,11,14]]},"reference":[{"key":"S0899823X18002751_ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-009-0869-3"},{"key":"S0899823X18002751_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e3283630f04"},{"key":"S0899823X18002751_ref11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030170"},{"key":"S0899823X18002751_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2015.08.005"},{"key":"S0899823X18002751_ref15","doi-asserted-by":"publisher","DOI":"10.1086\/521854"},{"key":"S0899823X18002751_ref14","doi-asserted-by":"publisher","DOI":"10.7326\/M15-1192"},{"key":"S0899823X18002751_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31588-4"},{"key":"S0899823X18002751_ref1","doi-asserted-by":"publisher","DOI":"10.1086\/670223"},{"key":"S0899823X18002751_ref7","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2013-202109"},{"key":"S0899823X18002751_ref8","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00634-09"},{"key":"S0899823X18002751_ref10","doi-asserted-by":"publisher","DOI":"10.1086\/670215"},{"key":"S0899823X18002751_ref13","doi-asserted-by":"publisher","DOI":"10.1086\/658669"},{"key":"S0899823X18002751_ref16","doi-asserted-by":"publisher","DOI":"10.1086\/521855"},{"key":"S0899823X18002751_ref17","doi-asserted-by":"publisher","DOI":"10.1086\/669084"},{"key":"S0899823X18002751_ref3","doi-asserted-by":"publisher","DOI":"10.1086\/527395"},{"key":"S0899823X18002751_ref9","doi-asserted-by":"publisher","DOI":"10.1086\/655016"},{"key":"S0899823X18002751_ref5","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02601-10"}],"container-title":["Infection Control & Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X18002751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T17:16:53Z","timestamp":1555089413000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X18002751\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,14]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S0899823X18002751"],"URL":"https:\/\/doi.org\/10.1017\/ice.2018.275","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,14]]}}}