{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:11:04Z","timestamp":1790457064238,"version":"4.1.0"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T00:00:00Z","timestamp":1522886400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2018,6]]},"abstract":"\n OBJECTIVE<\/jats:title>\n \n To compare the epidemiology, clinical characteristics, and mortality of patients with bloodstream infections (BSI) caused by extended-spectrum \u03b2-lactamase (ESBL)-producing\n Escherichia coli<\/jats:italic>\n (ESBL-EC) versus ESBL-producing\n Klebsiella pneumoniae<\/jats:italic>\n (ESBL-KP) and to examine the differences in clinical characteristics and outcome between BSIs caused by isolates with CTX-M versus other ESBL genotypes\n <\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n As part of the INCREMENT project, 33 tertiary hospitals in 12 countries retrospectively collected data on adult patients diagnosed with ESBL-EC BSI or ESBL-KP BSI between 2004 and 2013. Risk factors for ESBL-EC versus ESBL-KP BSI and for 30-day mortality were examined by bivariate analysis followed by multivariable logistic regression.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n The study included 909 patients: 687 with ESBL-EC BSI and 222 with ESBL-KP BSI. ESBL genotype by polymerase chain reaction amplification of 286 isolates was available. ESBL-KP BSI was associated with intensive care unit admission, cardiovascular and neurological comorbidities, length of stay to bacteremia >14 days from admission, and a nonurinary source. Overall, 30-day mortality was significantly higher in patients with ESBL-KP BSI than ESBL-EC BSI (33.7% vs 17.4%; odds ratio, 1.64;\n P<\/jats:italic>\n =.016). CTX-M was the most prevalent ESBL subtype identified (218 of 286 polymerase chain reaction-tested isolates, 76%). No differences in clinical characteristics or in mortality between CTX-M and non\u2013CTX-M ESBLs were detected.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n Clinical characteristics and risk of mortality differ significantly between ESBL-EC and ESBL-KP BSI. Therefore, all ESBL-producing Enterobacteriaceae should not be considered a homogeneous group. No differences in outcomes between genotypes were detected.<\/jats:p>\n <\/jats:sec>\n \n CLINICAL TRIALS IDENTIFIER<\/jats:title>\n ClinicalTrials.gov. Identifier: NCT01764490.<\/jats:p>\n \n Infect Control Hosp Epidemiol<\/jats:italic>\n 2018;39:660\u2013667\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1017\/ice.2018.63","type":"journal-article","created":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T03:56:16Z","timestamp":1522900576000},"page":"660-667","source":"Crossref","is-referenced-by-count":64,"title":["Comparison of Predictors and Mortality Between Bloodstream Infections Caused by ESBL-Producing\n Escherichia coli<\/i>\n and ESBL-Producing\n Klebsiella 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