{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T14:05:10Z","timestamp":1775225110257,"version":"3.50.1"},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T00:00:00Z","timestamp":1570492800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0899823X1900237X_as1\"><jats:title>Objective:<\/jats:title><jats:p>Peripherally inserted central catheters (PICCs) are a mainstay of nonpermanent vascular access devices. In this study, we assessed patients displaying anaphylaxis or anaphylactoid reactions to the PowerPICC SOLO and Groshong PICC (Bard Access Systems) using the Sherlock tip locating system (TLS).<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X1900237X_as2\"><jats:title>Methods:<\/jats:title><jats:p>Patients from 2 tertiary-care hospitals were systematically monitored over 4 years for adverse events following the insertion of a PICC using the Sherlock TLS. Insertion data were also collected using the BioFlo PICC (Angiodynamics)from a third hospital site and from The Ottawa Hospital over 4 years as an additional comparator. Three definitions of anaphylaxis and anaphylactoid reactions were utilized, and the Cohen \u03ba was used to assess interrater agreement. Analysis of reactions among the patient cohorts was performed using the \u03c7<jats:sup>2<\/jats:sup> test with Yates correction or the Fisher exact test as appropriate.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X1900237X_as3\"><jats:title>Results:<\/jats:title><jats:p>Among 8,257 insertions using the TLS PICCs, 37 potential reactions (0.45%) were recorded. Using specific definitions for anaphylaxis or anaphylactoid reactions, 54.1%\u201391.9% met criteria. Comparator populations using data from Calgary (n = 491) and Ottawa (n = 7,889) using the BioFlo PICC insertion found no reactions. Anaphylactic or anaphylactoid reactions were significantly associated with the PowerPICC SOLO and Groshong PICC with the TLS compared to the BioFlo PICC (<jats:italic>P<\/jats:italic> &lt; .0001) across all definitions. The largest subset of patients experiencing adverse reactions had cystic fibrosis (CF) (n = 4, 10.8%).<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X1900237X_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>Our study results demonstrate significant adverse events associated with the PowerPICC SOLO and Groshong PICC using the Sherlock TLS inserted across a range of patient populations. The incidence rate of anaphylaxis or anaphylactoid reactions in the CF population at our center is significantly higher than in non-CF patients (<jats:italic>P<\/jats:italic> &lt; .001).<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2019.237","type":"journal-article","created":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T05:27:32Z","timestamp":1570512452000},"page":"1215-1221","source":"Crossref","is-referenced-by-count":5,"title":["Anaphylaxis and anaphylactoid reactions associated with the insertion of peripherally inserted central catheters: A multiyear comparative retrospective cohort study"],"prefix":"10.1017","volume":"40","author":[{"given":"Christina S.","family":"Thornton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jody","family":"Dumanski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cherylanne","family":"Margherit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Vaz-Gonsalves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheryl","family":"McDiarmid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Parkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Conly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2019,10,8]]},"reference":[{"key":"S0899823X1900237X_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2013.09.002"},{"key":"S0899823X1900237X_ref10","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-123-11-199512010-00005"},{"key":"S0899823X1900237X_ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-016-0161-0"},{"key":"S0899823X1900237X_ref20","unstructured":"20. Office of Surveillance and Biometrics CfDaRH, Food and Drug Administration. Adverse medical device experience reports for Menlo Care from the Device Experience Network. 1990."},{"key":"S0899823X1900237X_ref9","first-page":"23","article-title":"Hypersensitivity-like reactions related to insertion of aquavene-based midline and PICC catheters","volume":"20","author":"Vanek","year":"1997","journal-title":"J Intraven Nurs"},{"key":"S0899823X1900237X_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.01.006"},{"key":"S0899823X1900237X_ref11","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-125-8-199610150-00015"},{"key":"S0899823X1900237X_ref16","unstructured":"16. Huang V DI , Scarazzini L. Pharmacovigilance review. Focalin and focalin XR. Office of Surveillance and Epidemiology: Department of Health and Human Services, Public Health Service, Good and Drug Administration. Center for Drug Evaluation and Research, 2011."},{"key":"S0899823X1900237X_ref4","doi-asserted-by":"publisher","DOI":"10.1086\/657942"},{"key":"S0899823X1900237X_ref1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2013.773072"},{"key":"S0899823X1900237X_ref23","doi-asserted-by":"publisher","DOI":"10.2174\/138161211798357917"},{"key":"S0899823X1900237X_ref3","doi-asserted-by":"publisher","DOI":"10.4065\/81.9.1159"},{"key":"S0899823X1900237X_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91320-L"},{"key":"S0899823X1900237X_ref7","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.8.747"},{"key":"S0899823X1900237X_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.06.022"},{"key":"S0899823X1900237X_ref8","doi-asserted-by":"publisher","DOI":"10.5301\/jva.5000330"},{"key":"S0899823X1900237X_ref12","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.12704"},{"key":"S0899823X1900237X_ref14","doi-asserted-by":"publisher","DOI":"10.9778\/cmajo.20170010"},{"key":"S0899823X1900237X_ref15","unstructured":"15. 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