{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T13:47:18Z","timestamp":1744120038509},"reference-count":22,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T00:00:00Z","timestamp":1578009600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S0899823X19003222_as1\">\n\t    <jats:title>Objective:<\/jats:title>\n\t    <jats:p>To evaluate whether clinical cultures are an appropriate surrogate for surveillance cultures to measure the effect of interventions on the incidence of MRSA and VRE in the hospital.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0899823X19003222_as2\">\n\t    <jats:title>Design:<\/jats:title>\n\t    <jats:p>Cross-sectional and quasi-experimental, retrospective analysis<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0899823X19003222_as3\">\n\t    <jats:title>Setting and population:<\/jats:title>\n\t    <jats:p>Convenience sample of patients admitted between January 1, 2002, and June 31, 2011, to the medical intensive care unit (MICU) and surgical intensive care unit (SICU) of an acute-care hospital in the United States.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0899823X19003222_as4\">\n\t    <jats:title>Interventions:<\/jats:title>\n\t    <jats:p>Asynchronously in the MICU and SICU, we introduced (1) universal glove and gown use, (2) bundled intervention to prevent central-line\u2013associated bloodstream infection, and (3) daily chlorhexidine gluconate bathing.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0899823X19003222_as5\">\n\t    <jats:title>Results:<\/jats:title>\n\t    <jats:p>We observed a statistically significant correlation between surveillance and clinical culture-based incidence rates of MRSA in the MICU (0.32; <jats:italic>P<\/jats:italic> &lt; .001) and the SICU (0.37; <jats:italic>P<\/jats:italic> &lt; .001) but not for VRE in either the MICU (0.16, <jats:italic>P<\/jats:italic> = .11) or the SICU (0.15; <jats:italic>P<\/jats:italic> = .12). For VRE, but not for MRSA, incidence density rates based on surveillance cultures were 2- to 4-fold higher than for clinical cultures. When evaluating the impacts of the interventions, different effect estimates were noted for universal glove and gown use on MRSA acquisition in MICU, and for VRE acquisition in both the MICU and the SICU based on surveillance versus clinical cultures.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0899823X19003222_as6\">\n\t    <jats:title>Conclusions:<\/jats:title>\n\t    <jats:p>For multidrug-resistant organism acquisition, surveillance cultures should be used when feasible because clinical cultures may not be an appropriate surrogate. Clinical or surveillance-based end points for infection control interventions should reflect the conceptual model from colonization to infection and where an intervention might have an effect, rather than considering them interchangeable.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/ice.2019.322","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T05:23:59Z","timestamp":1578029039000},"page":"1-5","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of surveillance and clinical cultures to measure the impact of infection control interventions on the incidence of methicillin-resistant <i>Staphylococcus aureus<\/i> and vancomycin-resistant <i>Enterococcus<\/i> in the hospital"],"prefix":"10.1017","author":[{"given":"Surbhi","family":"Leekha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyndsay M.","family":"O\u2019Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyssa","family":"Sbarra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony D.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,1,3]]},"reference":[{"key":"S0899823X19003222_ref21","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2016.156"},{"key":"S0899823X19003222_ref17","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01590-09"},{"key":"S0899823X19003222_ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-018-0412-3"},{"key":"S0899823X19003222_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-016-2843-1"},{"key":"S0899823X19003222_ref12","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000921"},{"key":"S0899823X19003222_ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-018-3341-6"},{"key":"S0899823X19003222_ref11","doi-asserted-by":"publisher","DOI":"10.1097\/01.qco.0000136926.52673.cd"},{"key":"S0899823X19003222_ref4","doi-asserted-by":"publisher","DOI":"10.1086\/507636"},{"key":"S0899823X19003222_ref16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024340"},{"key":"S0899823X19003222_ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1000373"},{"key":"S0899823X19003222_ref1","first-page":"1571","article-title":"Universal glove and gown use and acquisition of antibiotic-resistant bacteria in the ICU: a randomized trial","volume":"310","author":"Harris","year":"2013","journal-title":"JAMA"},{"key":"S0899823X19003222_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2017.08.031"},{"key":"S0899823X19003222_ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113849"},{"key":"S0899823X19003222_ref5","doi-asserted-by":"publisher","DOI":"10.1086\/657668"},{"key":"S0899823X19003222_ref18","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-491"},{"key":"S0899823X19003222_ref6","doi-asserted-by":"publisher","DOI":"10.1086\/518348"},{"key":"S0899823X19003222_ref8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2710.2002.00430.x"},{"key":"S0899823X19003222_ref20","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2018.57"},{"key":"S0899823X19003222_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2018.07.011"},{"key":"S0899823X19003222_ref19","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2015.156"},{"key":"S0899823X19003222_ref10","doi-asserted-by":"publisher","DOI":"10.1086\/376624"},{"key":"S0899823X19003222_ref9","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.10.1127"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X19003222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T05:24:01Z","timestamp":1578029041000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X19003222\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,3]]},"references-count":22,"alternative-id":["S0899823X19003222"],"URL":"https:\/\/doi.org\/10.1017\/ice.2019.322","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,3]]}}}