{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:01:38Z","timestamp":1760551298085,"version":"3.40.5"},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0899823X20013215_as1\"><jats:title>Objective:<\/jats:title><jats:p>To evaluate the epidemiological and clinical characteristics of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) infection among healthcare workers (HCWs) in Hubei Province, China.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20013215_as2\"><jats:title>Design:<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20013215_as3\"><jats:title>Setting:<\/jats:title><jats:p>Hubei Provincial Center for Disease Control and Prevention.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20013215_as4\"><jats:title>Participants:<\/jats:title><jats:p>The participants in this study are cases identified by epidemiological investigation in Hubei Province, as of February 27, 2020, and were followed until March 7, 2020. In total, 1,989 HCWs and 41,137 other occupational cases were included for analysis.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20013215_as5\"><jats:title>Methods:<\/jats:title><jats:p>We used descriptive statistics to summarize patient characteristics.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20013215_as6\"><jats:title>Results:<\/jats:title><jats:p>Of 1,989 laboratory-confirmed HCWs, 297 (14.93%) had severe or critical cases, 73 (3.67%) had asymptomatic infections, and 18 died of coronavirus disease 2019 (COVID-19). The case fatality rate was 0.9%. The proportion of severe or critical cases decreased from the beginning to the end of the outbreak (from 21.29% to 3.52%), and the proportion of asymptomatic cases increased from 0.0% to 47.18%. Nearly half of HCWs with confirmed COVID-19 reported no known contact with COVID-19 patients (969, 48.72%). Fever and cough were the most common symptoms at disease onset in both HCWs and other occupational cases; however, HCWs had higher rates of fatigue (30.90% vs 25.02%; <jats:italic>P<\/jats:italic> &lt; .001) and myalgia (19.15% vs 13.43%; <jats:italic>P<\/jats:italic> &lt; .001). Additionally, compared with other occupational groups, HCWs were associated with a lower risk of death after adjustment for potential confounders (odd ratio [OR], 0.50; 95% confidence interval [CI], 0.30\u20130.79).<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20013215_as7\"><jats:title>Conclusions:<\/jats:title><jats:p>Compared with COVID-19 cases in other occupational groups, HCWs with COVID-19 have half the risk of death, although they have been shown to have higher rates of fatigue and myalgia.<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2020.1321","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T08:10:29Z","timestamp":1605687029000},"page":"924-930","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":7,"title":["Epidemiological and clinical characteristics of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) infection among healthcare workers in Hubei Province, China"],"prefix":"10.1017","volume":"42","author":[{"given":"Mingyang","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanling","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lulin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7031-2972","authenticated-orcid":false,"given":"Youjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"key":"S0899823X20013215_ref15","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"S0899823X20013215_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"S0899823X20013215_ref23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72164-7"},{"key":"S0899823X20013215_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(20)30078-X"},{"key":"S0899823X20013215_ref20","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.6130"},{"key":"S0899823X20013215_ref17","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12803"},{"key":"S0899823X20013215_ref16","unstructured":"16. Coronavirus (COVID-19). World Health Organization website. https:\/\/covid19.who.int\/. Published 2020. Accessed April 21, 2020."},{"key":"S0899823X20013215_ref10","doi-asserted-by":"publisher","DOI":"10.1177\/070674370905400504"},{"key":"S0899823X20013215_ref19","first-page":"87","article-title":"An investigation on nosocomial infection with severe acute respiratory syndrome in health-care workers at 13 key hospitals in Guangdong Province","volume":"38","author":"Zou","year":"2004","journal-title":"Zhonghua yu fang yi xue za zhi"},{"key":"S0899823X20013215_ref4","unstructured":"4. Coronavirus disease (COVID-19) pandemic. World Health Organization website. https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019. Published 2020. 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Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America. All rights reserved","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}