{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T21:10:49Z","timestamp":1780089049943,"version":"3.54.0"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2020,8]]},"abstract":"Abstract<\/jats:title>Objective:<\/jats:title>To evaluate the impact of a pharmacist-driven Staphylococcus aureus<\/jats:italic> bacteremia (SAB) safety bundle supported by leadership and to compare compliance before and after implementation.<\/jats:p><\/jats:sec>Design:<\/jats:title>Retrospective cohort study with descriptive and before-and-after analyses.<\/jats:p><\/jats:sec>Setting:<\/jats:title>Tertiary-care academic medical center.<\/jats:p><\/jats:sec>Patients:<\/jats:title>All patients with documented SAB, regardless of the source of infection, were included. Patients transitioned to palliative care were excluded from before-and-after analysis.<\/jats:p><\/jats:sec>Methods:<\/jats:title>A pharmacist-driven safety bundle including documented clearance of bacteremia, echocardiography, removal of central venous catheters, and targeted intravenous therapy of at least 2 weeks duration was implemented in November 2015 and was supported by leadership with stepwise escalation for nonresponse. A descriptive analysis of all patients with SAB during the study period included pharmacy interventions, acceptance rates, and escalation rates. A pre\u2013post implementation analysis of 100 sequential patients compared bundle compliance and descriptive parameters.<\/jats:p><\/jats:sec>Results:<\/jats:title>Overall, 391 interventions were made in the 20-month period following implementation, including 20 \u201cgood saves\u201d avoiding potentially major adverse events. No statistically significant differences in complete bundle compliance were detected between the periods (74% vs 84%; P<\/jats:italic> = .08). However, we detected a significant increase in echocardiography after the bundle was implemented (83% vs 94%; P<\/jats:italic> = .02) and fewer patients received suboptimal definitive therapy after the bundle was implemented (10% vs 3%; P<\/jats:italic> = .045).<\/jats:p><\/jats:sec>Conclusions:<\/jats:title>This pharmacist-driven SAB safety bundle with leadership support showed improvement in process measures, which may have prevented major adverse events, even with available infectious diseases (ID) consultation. It provides a critical safety net for institutions without mandatory ID consultation or with limited antimicrobial stewardship resources.<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2020.143","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T04:48:48Z","timestamp":1592282928000},"page":"921-925","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Description of a pharmacist-driven safety algorithm in Staphylococcus aureus<\/i> bacteremia: Compliance, interventions, and good saves"],"prefix":"10.1017","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2194-3772","authenticated-orcid":false,"given":"Tara H.","family":"Lines","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6454-171X","authenticated-orcid":false,"given":"Whitney J.","family":"Nesbitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5452-2304","authenticated-orcid":false,"given":"Matthew H.","family":"Greene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2701-1917","authenticated-orcid":false,"given":"George E.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,6,16]]},"reference":[{"key":"S0899823X20001439_ref17","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofy210.1053"},{"key":"S0899823X20001439_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-014-0633-1"},{"key":"S0899823X20001439_ref13","first-page":"3390","article-title":"Impact of an antimicrobial stewardship-led intervention for Staphylococcus aureus bacteraemia: a quasi-experimental study","volume":"70","author":"Nguyen","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"S0899823X20001439_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"S0899823X20001439_ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-016-0946-3"},{"key":"S0899823X20001439_ref7","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir034"},{"key":"S0899823X20001439_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.09.016"},{"key":"S0899823X20001439_ref15","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ120"},{"key":"S0899823X20001439_ref1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit730"},{"key":"S0899823X20001439_ref4","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jer023"},{"key":"S0899823X20001439_ref5","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000091185.93122.40"},{"key":"S0899823X20001439_ref6","doi-asserted-by":"publisher","DOI":"10.14503\/THIJ-15-5359"},{"key":"S0899823X20001439_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix315"},{"key":"S0899823X20001439_ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1296-y"},{"key":"S0899823X20001439_ref9","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit499"},{"key":"S0899823X20001439_ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03156.x"},{"key":"S0899823X20001439_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2017.10.001"},{"key":"S0899823X20001439_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2014.05.004"},{"key":"S0899823X20001439_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2017.02.030"},{"key":"S0899823X20001439_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2015.09.037"}],"container-title":["Infection Control & Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X20001439","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T10:35:49Z","timestamp":1595932549000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X20001439\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,16]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S0899823X20001439"],"URL":"https:\/\/doi.org\/10.1017\/ice.2020.143","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,16]]},"assertion":[{"value":"\u00a9 2020 by The Society for Healthcare Epidemiology of America. 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