{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T21:29:15Z","timestamp":1773091755012,"version":"3.50.1"},"reference-count":35,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T00:00:00Z","timestamp":1593388800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0899823X20002779_as1\"><jats:title>Objective:<\/jats:title><jats:p>Recently, oral vancomycin prophylaxis (OVP) has been suggested for the prevention of <jats:italic>Clostridium difficile<\/jats:italic> infection (CDI). We conducted a systematic review and meta-analysis to investigate the efficacy and safety of this approach.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20002779_as2\"><jats:title>Design:<\/jats:title><jats:p>Systematic review and meta-analysis.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20002779_as3\"><jats:title>Methods:<\/jats:title><jats:p>We conducted a computerized search of MEDLINE, EMBASE, and Cochrane databases from inception to March 2019 for publications investigating OVP for CDI prevention. Results were screened for eligibility. Relevant data were extracted and analyzed. Publication bias was assessed using the Egger test.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20002779_as4\"><jats:title>Results:<\/jats:title><jats:p>Ultimately, 8 retrospective studies and 1 prospective study examining 2174 patients, published between 2016 and 2019 were included in the review. OVP was associated with decreased CDI (odds ratio, 0.263; 95% confidence interval, 0.13\u20130.52) with considerable heterogeneity (I<jats:sup>2<\/jats:sup> = 61%). Meta-regression showed that total daily dose of OVP correlated with CDI, explaining 100% of heterogeneity between studies. Furthermore, 3 studies evaluated the risk of vancomycin-resistant enterococci (VRE) infection after OVP and found no significant increase.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20002779_as5\"><jats:title>Conclusion:<\/jats:title><jats:p>Our results suggest that OVP might decrease CDI rates in at-risk populations, although this conclusion should be interpreted with caution. Higher daily doses of OVP might increase CDI. Although the use of OVP in high-risk patients may reduce CDI, this suggestion has yet to be validated by prospective blinded randomized controlled trials.<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2020.277","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T08:24:43Z","timestamp":1593419083000},"page":"1302-1309","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":31,"title":["Oral vancomycin prophylaxis for the prevention of <i>Clostridium difficile<\/i> infection: A systematic review and meta-analysis"],"prefix":"10.1017","volume":"41","author":[{"given":"Sumbal","family":"Babar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8048-7001","authenticated-orcid":false,"given":"Bara","family":"El Kurdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"El Iskandarani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Haddad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3030-6188","authenticated-orcid":false,"given":"Zaid","family":"Imam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Alomari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Myers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Moorman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,6,29]]},"reference":[{"key":"S0899823X20002779_ref15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098400"},{"key":"S0899823X20002779_ref11","doi-asserted-by":"publisher","DOI":"10.1177\/1060028017706374"},{"key":"S0899823X20002779_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.06.021"},{"key":"S0899823X20002779_ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306801"},{"key":"S0899823X20002779_ref7","doi-asserted-by":"publisher","DOI":"10.1086\/430311"},{"key":"S0899823X20002779_ref30","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw383"},{"key":"S0899823X20002779_ref18","unstructured":"18. Ottawa Hospital Research Institute website. http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp. Accessed April 3, 2019."},{"key":"S0899823X20002779_ref35","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02237-17"},{"key":"S0899823X20002779_ref23","doi-asserted-by":"publisher","DOI":"10.1177\/1060028017727756"},{"key":"S0899823X20002779_ref24","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy822"},{"key":"S0899823X20002779_ref9","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2016.246"},{"key":"S0899823X20002779_ref3","doi-asserted-by":"publisher","DOI":"10.1086\/430315"},{"key":"S0899823X20002779_ref29","doi-asserted-by":"publisher","DOI":"10.1177\/0897190019825994"},{"key":"S0899823X20002779_ref20","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.417"},{"key":"S0899823X20002779_ref34","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-002-0215-5"},{"key":"S0899823X20002779_ref14","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.12.038"},{"key":"S0899823X20002779_ref33","doi-asserted-by":"publisher","DOI":"10.1086\/513755"},{"key":"S0899823X20002779_ref4","doi-asserted-by":"publisher","DOI":"10.20524\/aog.2016.0006"},{"key":"S0899823X20002779_ref31","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02112-17"},{"key":"S0899823X20002779_ref12","doi-asserted-by":"publisher","DOI":"10.1086\/430315"},{"key":"S0899823X20002779_ref10","unstructured":"10. Butler, M , Olson, A , Drekonja, D , et al. Early diagnosis, prevention, and treatment of Clostridium difficile: update. Agency for Healthcare Research and Quality website. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK361173\/. Published 2016. Accessed May 5, 2019."},{"key":"S0899823X20002779_ref17","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"S0899823X20002779_ref22","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2019.88"},{"key":"S0899823X20002779_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.10.144"},{"key":"S0899823X20002779_ref26","doi-asserted-by":"publisher","DOI":"10.1080\/23744235.2018.1425551"},{"key":"S0899823X20002779_ref19","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw401"},{"key":"S0899823X20002779_ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-1610-3"},{"key":"S0899823X20002779_ref32","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-117-4-297"},{"key":"S0899823X20002779_ref16","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"S0899823X20002779_ref28","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.417"},{"key":"S0899823X20002779_ref21","doi-asserted-by":"publisher","DOI":"10.1177\/0897190019825994"},{"key":"S0899823X20002779_ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051590"},{"key":"S0899823X20002779_ref6","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-145-10-200611210-00008"},{"key":"S0899823X20002779_ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408913"},{"key":"S0899823X20002779_ref27","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz966"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X20002779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T13:25:26Z","timestamp":1603891526000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X20002779\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,29]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S0899823X20002779"],"URL":"https:\/\/doi.org\/10.1017\/ice.2020.277","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,29]]},"assertion":[{"value":"\u00a9 2020 by The Society for Healthcare Epidemiology of America. All rights reserved.","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}