{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T21:20:34Z","timestamp":1773436834687,"version":"3.50.1"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0899823X20004043_as1\"><jats:title>Objective:<\/jats:title><jats:p>To report a conjunctivitis outbreak in a neonatology intensive care unit (NICU) and determine the associated economic impact.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20004043_as2\"><jats:title>Design:<\/jats:title><jats:p>Prospective observational study.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20004043_as3\"><jats:title>Setting:<\/jats:title><jats:p>Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas (CEMIC) University Hospital, a private, tertiary-care healthcare institution in Buenos Aires, Argentina.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20004043_as4\"><jats:title>Participants:<\/jats:title><jats:p>The study included 52 NICU neonates and 59 NICU-related healthcare workers (HCWs) from CEMIC hospital.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20004043_as5\"><jats:title>Methods:<\/jats:title><jats:p>Neonates and HCWs were swabbed for real-time polymerase chain reaction (PCR) testing, viral culture, and typing by sequencing. Infection control measures, structural and logistic changes were implemented. Billing records were analyzed to determine costs.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20004043_as6\"><jats:title>Results:<\/jats:title><jats:p>From January 30 to April 28, 2018, 52 neonates were hospitalized in the NICU. Among them, 14 of 52 (21%) had bilateral conjunctivitis with pseudomembranes. Symptomatic neonates and HCWs were HAdV-D8 positive. Ophthalmological symptoms had a median duration of 18 days (IQR, 13\u201324.5). PCR positivity and infectious range had a median duration of 18.5 days. As part of containment measures, the NICU and the high-risk pregnancy unit were closed to new patients. The NICU was divided into 2 areas for symptomatic and asymptomatic patients; a new room was assigned for the general nursery, and all deliveries from the high-risk pregnancy unit were redirected to other hospitals. The outbreak cost the hospital US$205,000: implementation of a new nursery room and extra salaries cost US$30,350 and estimated productivity loss during 1 month cost US$175,000.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20004043_as7\"><jats:title>Conclusions:<\/jats:title><jats:p>Laboratory diagnosis confirmed the cause of this outbreak as HAdV-D8. The immediate adoption and reinforcement of rigorous infection control measures limited the nosocomial viral spread. This outbreak represented a serious institutional problem, causing morbidity, significant economic loss, and absenteeism.<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2020.404","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T05:51:35Z","timestamp":1599630695000},"page":"142-148","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["Direct costs and clinical impact of adenovirus genotype 8 conjunctivitis outbreak in a neonatology unit"],"prefix":"10.1017","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2051-7149","authenticated-orcid":false,"given":"Mar\u00eda Florencia","family":"Angueyra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora Natalia","family":"Marcone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florencia","family":"Escarr\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noelia Soledad","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yamile","family":"Rubies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delcys","family":"Albas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela Elizabeth","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Vidaurreta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guadalupe","family":"Carballal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Echavarria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"S0899823X20004043_ref2","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.13687"},{"key":"S0899823X20004043_ref13","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31816060bb"},{"key":"S0899823X20004043_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2011.11.007"},{"key":"S0899823X20004043_ref21","first-page":"475","article-title":"Keratokonjunktivitis epidemica\u2014 Infektionslage und aktuelle hinweise zu prophylaxe und therapie","volume":"108","author":"Meyer-R\u00fcsenberg","year":"2011","journal-title":"Dtsch Arztebl"},{"key":"S0899823X20004043_ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-016-2804-0"},{"key":"S0899823X20004043_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.11.032"},{"key":"S0899823X20004043_ref3","article-title":"Adenovirus genotypes to be used in phylogenetic analysis","author":"Marcone","year":"2019","journal-title":"Mendeley Data"},{"key":"S0899823X20004043_ref17","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.56.2.120"},{"key":"S0899823X20004043_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.07.008"},{"key":"S0899823X20004043_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-005-0722-7"},{"key":"S0899823X20004043_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2010.10.020"},{"key":"S0899823X20004043_ref10","doi-asserted-by":"publisher","DOI":"10.3109\/09286586.2012.718402"},{"key":"S0899823X20004043_ref19","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25223"},{"key":"S0899823X20004043_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2014.10.015"},{"key":"S0899823X20004043_ref14","article-title":"Adenovirus genotypes and phylogenetic analysis in children with respiratory infection in Buenos Aires, Argentina (2000\u20132018)","author":"Marcone","journal-title":"Infection, Genetics and Evolution"},{"key":"S0899823X20004043_ref11","doi-asserted-by":"publisher","DOI":"10.4321\/S0365-66912007000200004"},{"key":"S0899823X20004043_ref18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185048"},{"key":"S0899823X20004043_ref22","doi-asserted-by":"publisher","DOI":"10.1067\/mic.2002.125193"},{"key":"S0899823X20004043_ref1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00052-07"},{"key":"S0899823X20004043_ref4","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-9656"},{"key":"S0899823X20004043_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2015.04.001"},{"key":"S0899823X20004043_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(93)31389-8"}],"container-title":["Infection Control &amp; 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