{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:00:58Z","timestamp":1788235258471,"version":"build-2803163510"},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2020,12]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n \n Candida auris is<\/jats:italic>\n an emerging and often multidrug-resistant fungal pathogen with an exceptional ability to persist on hospital surfaces. These surfaces can act as a potential source of transmission. Therefore, effective disinfection strategies are urgently needed. We investigated the efficacy of ultraviolet C light (UV-C) disinfection for\n C. auris<\/jats:italic>\n isolates belonging to 4 different clades.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n In vitro testing of\n C. auris<\/jats:italic>\n isolates was conducted using 10\n 6<\/jats:sup>\n colony-forming units (CFU) spread on 20-mm diameter steel carriers and exposed to a broad-spectrum UV-C light source for 10, 20, and 30 minutes at a 1.5 m (5 feet) distance. Post-UV survivors on the coupons were subsequently plated. Colony counts and log reductions were recorded, calculated, and compared to untreated control carriers. Identification of all isolates were confirmed by MALDI-TOF and morphology was visualized by microscopy.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n We observed an increased susceptibility of\n C. auris<\/jats:italic>\n to UV-C in 8 isolates belonging to clades I, II and IV with increasing UV exposure time. The range of log kill (0.8\u20131.19) was highest for these isolates at 30 minutes. But relatively no change in log kill (0.04\u20130.35) with increasing time in isolates belonging to clade III were noted. Interestingly,\n C. auris<\/jats:italic>\n isolates susceptible to UV-C were mostly nonaggregating, but the isolates that were more resistant to UV exposure formed aggregates.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n \n Our study suggests variability in susceptibility to UV-C of\n C. auris<\/jats:italic>\n isolates belonging to different clades. More studies are needed to assess whether a cumulative impact of prolonged UV-C exposure provides additional benefit.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1017\/ice.2020.410","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T02:29:18Z","timestamp":1602556158000},"page":"1384-1387","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":27,"title":["Clade-specific variation in susceptibility of\n Candida auris<\/i>\n to broad-spectrum ultraviolet C light (UV-C)"],"prefix":"10.1017","volume":"41","author":[{"given":"Piyali","family":"Chatterjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hosoon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brennan","family":"Ochoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennifer","family":"Garmon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Coppin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonhui","family":"Allton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janell","family":"Lukey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjory D.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhammika","family":"Navarathna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3916-952X","authenticated-orcid":false,"given":"Chetan","family":"Jinadatha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,10,13]]},"reference":[{"key":"S0899823X20004109_ref13","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1093\/cid\/cix629","article-title":"Hospital sinks are a potential nosocomial source of Candida infections","volume":"65","author":"Jencson","year":"2017","journal-title":"Clin Infect Dis"},{"key":"S0899823X20004109_ref17","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1186\/s12879-019-4137-6","article-title":"The efficacy of pulsed-xenon ultraviolet light technology on Candida auris","volume":"19","author":"Maslo","year":"2019","journal-title":"BMC Infect Dis"},{"key":"S0899823X20004109_ref7","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jhin.2017.11.015","article-title":"Surface disinfection challenges for Candida auris: an in-vitro study","volume":"98","author":"Kean","year":"2018","journal-title":"J Hosp Infect"},{"key":"S0899823X20004109_ref8","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2017.162"},{"key":"S0899823X20004109_ref11","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/myc.12903","article-title":"Killing of Candida auris by UV-C: importance of exposure time and distance","volume":"62","author":"de Groot","year":"2019","journal-title":"Mycoses"},{"key":"S0899823X20004109_ref2","unstructured":"2. Candida auris fungal diseases. Centers for Disease Control and Prevention website. https:\/\/www.cdc.gov\/fungal\/candida-auris\/index.html. Updated 2019. Accessed August 11, 2020."},{"key":"S0899823X20004109_ref6","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00189-16"},{"key":"S0899823X20004109_ref16","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02055-18"},{"key":"S0899823X20004109_ref10","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2017.239"},{"key":"S0899823X20004109_ref15","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000603"},{"key":"S0899823X20004109_ref5","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.mib.2019.05.008","article-title":"Global epidemiology of emerging Candida auris","volume":"52","author":"Rhodes","year":"2019","journal-title":"Curr Opin Microbiol"},{"key":"S0899823X20004109_ref9","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1017\/ice.2014.36","article-title":"Evaluation of a pulsed xenon ultraviolet disinfection system for reduction of healthcare-associated pathogens in hospital rooms","volume":"36","author":"Nerandzic","year":"2015","journal-title":"Infect Control Hosp Epidemiol"},{"key":"S0899823X20004109_ref12","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6619a7"},{"key":"S0899823X20004109_ref3","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1017\/ice.2017.127","article-title":"Environmental surfaces in healthcare facilities are a potential source for transmission of Candida auris and other Candida species","volume":"38","author":"Piedrahita","year":"2017","journal-title":"Infect Control Hosp Epidemiol"},{"key":"S0899823X20004109_ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2008.00083.x"},{"key":"S0899823X20004109_ref4","doi-asserted-by":"crossref","first-page":"260","DOI":"10.20411\/pai.v4i2.291","article-title":"Environmental contamination with Candida species in multiple hospitals including a tertiary-care hospital with a Candida auris outbreak","volume":"4","author":"Kumar","year":"2019","journal-title":"Pathog Immun"},{"key":"S0899823X20004109_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2018.06.007"}],"container-title":["Infection Control & Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X20004109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T06:56:48Z","timestamp":1607065008000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X20004109\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,13]]},"references-count":17,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S0899823X20004109"],"URL":"https:\/\/doi.org\/10.1017\/ice.2020.410","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,13]]},"assertion":[{"value":"\u00a9 2020 by The Society for Healthcare Epidemiology of America. All rights reserved.","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}