{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:49:59Z","timestamp":1793137799959,"version":"4.5.0"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0899823X20004146_as1\"><jats:title>Objective:<\/jats:title><jats:p>To describe local experience in managing an outbreak of<jats:italic>Candida auris<\/jats:italic>in a tertiary-care setting.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20004146_as2\"><jats:title>Methods:<\/jats:title><jats:p>In response to emerging<jats:italic>Candida auris<\/jats:italic>, an outbreak investigation was conducted at our hospital between March 2018 and June 2019. Once a patient was confirmed to have<jats:italic>Candida auris<\/jats:italic>, screening of exposed patients and healthcare workers (HCWs) was conducted. Postexposure screening included those who had had direct contact with or shared the same unit or ward with a laboratory-confirmed case. In response to the increasing number of cases, new infection control measures were implemented.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20004146_as3\"><jats:title>Results:<\/jats:title><jats:p>In total, 23 primary patients were detected over 15 months. Postexposure screening identified 11 more cases, and all were patients. Furthermore, ~28.6% of patients probably caught infection in another hospital or in the community. Infection control measures were strictly implemented including hand hygiene, personal protective equipment, patient hygiene, environmental cleaning, cohorting of patients and HCWs, and avoiding the sharing of equipment. The wave reached a peak in April 2019, followed by a sharp decrease in May 2019 and complete clearance in June 2019. The case patients were equally distributed between intensive care units (51.4%) and wards (48.6%). More infections (62.9%) occurred than colonizations (37.1%). Urinary tract infection (42.9%) and candidemia (17.1%) were the main infections. In total, 7 patients (20.0%) died during hospitalization; among them, 6 (17.1%) died within 30 days of diagnosis.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20004146_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>Active screening of exposed patients followed by strict infection control measures, including environmental cleaning, was successful in ending the outbreak. Preventing future outbreaks is challenging due to outside sources of infection and environmental resistance.<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2020.414","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T09:26:06Z","timestamp":1599125166000},"page":"149-155","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":48,"title":["Management of<i>Candida auris<\/i>outbreak in a tertiary-care setting in Saudi Arabia"],"prefix":"10.1017","volume":"42","author":[{"given":"Majid M.","family":"Alshamrani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiman","family":"El-Saed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azzam","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majed F.","family":"Alghoribi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameera M.","family":"Al Johani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold","family":"Cabanalan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan H.","family":"Balkhy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,9,3]]},"reference":[{"key":"S0899823X20004146_ref5","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1093\/jac\/dkz178","article-title":"Antifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris","volume":"74","author":"Dudiuk","year":"2019","journal-title":"J Antimicrob Chemother"},{"key":"S0899823X20004146_ref25","article-title":"Ongoing challenges with healthcare-associated Candida auris outbreaks in Oman","volume":"5","author":"Al Maani","year":"2019","journal-title":"J Fungi (Basel)"},{"key":"S0899823X20004146_ref2","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.578"},{"key":"S0899823X20004146_ref8","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000603"},{"key":"S0899823X20004146_ref27","doi-asserted-by":"publisher","DOI":"10.3201\/eid2507.180491"},{"key":"S0899823X20004146_ref24","first-page":"15","article-title":"Molecular epidemiology of Candida auris in Colombia reveals a highly related, countrywide colonization with regional patterns in amphotericin B resistance","volume":"68","author":"Escandon","year":"2019","journal-title":"Clin Infect Dis"},{"key":"S0899823X20004146_ref21","unstructured":"21. National Healthcare Safety Network (NHSN) patient safety component manual. Centers for Disease Control and Prevention website. https:\/\/www.cdc.gov\/nhsn\/pdfs\/validation\/2018\/pcsmanual_2018-508.pdf. Published 2018. Accessed January 10, 2020."},{"key":"S0899823X20004146_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2017.09.009"},{"key":"S0899823X20004146_ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-018-0342-4"},{"key":"S0899823X20004146_ref18","doi-asserted-by":"publisher","DOI":"10.3390\/jof5040111"},{"key":"S0899823X20004146_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2018.09.014"},{"key":"S0899823X20004146_ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-019-0675-8"},{"key":"S0899823X20004146_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2019.06.006"},{"key":"S0899823X20004146_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2008.00083.x"},{"key":"S0899823X20004146_ref19","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2018-0508-RA"},{"key":"S0899823X20004146_ref6","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00921-17"},{"key":"S0899823X20004146_ref26","doi-asserted-by":"publisher","DOI":"10.1111\/imj.14612"},{"key":"S0899823X20004146_ref20","unstructured":"20. Infection prevention and control for Candida auris. Centers for Disease Control and Prevention website. https:\/\/www.cdc.gov\/fungal\/candida-auris\/c-auris-infection-control.html. Updated 2019. Accessed January 10, 2020."},{"key":"S0899823X20004146_ref12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1714373"},{"key":"S0899823X20004146_ref14","doi-asserted-by":"publisher","DOI":"10.3201\/eid2410.180649"},{"key":"S0899823X20004146_ref28","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.01588-17","article-title":"Candida auris: an emerging fungal pathogen","volume":"56","author":"Spivak","year":"2018","journal-title":"J Clin Microbiol"},{"key":"S0899823X20004146_ref13","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2019.1592675"},{"key":"S0899823X20004146_ref22","doi-asserted-by":"publisher","DOI":"10.20411\/pai.v4i2.291"},{"key":"S0899823X20004146_ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-016-0132-5"},{"key":"S0899823X20004146_ref11","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jiph.2019.03.009","article-title":"The emerging pathogen Candida auris: a focus on the Middle-Eastern countries","volume":"12","author":"Alfouzan","year":"2019","journal-title":"J Infect Public Health."},{"key":"S0899823X20004146_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2019.07.011"},{"key":"S0899823X20004146_ref4","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myy054"},{"key":"S0899823X20004146_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2018.05.010"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X20004146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T06:42:52Z","timestamp":1668580972000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X20004146\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,3]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S0899823X20004146"],"URL":"https:\/\/doi.org\/10.1017\/ice.2020.414","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,3]]},"assertion":[{"value":"\u00a9 2020 by The Society for Healthcare Epidemiology of America. All rights reserved.","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}