{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:25:03Z","timestamp":1787243103822,"version":"build-2736575974"},"reference-count":104,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T00:00:00Z","timestamp":1585267200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0899823X20000458_as1\" sec-type=\"other\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cohorting of patients and staff is a control strategy often used to prevent the spread of infection in healthcare institutions. However, a comprehensive evaluation of cohorting as a prevention approach is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X20000458_as2\" sec-type=\"other\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We performed a systematic review of studies that used cohorting as part of an infection control strategy to reduce hospital-acquired infections. We included studies published between 1966 and November 30, 2019, on adult populations hospitalized in acute-care hospitals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X20000458_as3\" sec-type=\"other\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In total, 87 studies met inclusion criteria. Study types were quasi-experimental \u201cbefore and after\u201d (n = 35), retrospective (n = 49), and prospective (n = 3). Case-control analysis was performed in 7 studies. Cohorting was performed with other infection control strategies in the setting of methicillin-resistant\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      (MRSA, n = 22),\n                      <jats:italic>Clostridioides difficile<\/jats:italic>\n                      infection (CDI, n = 6), vancomycin-resistant\n                      <jats:italic>Enterococcus<\/jats:italic>\n                      (VRE, n = 17), carbapenem-resistant Enterobacteriaceae infections (CRE, n = 22),\n                      <jats:italic>A. baumannii<\/jats:italic>\n                      (n = 15), and other gram-negative infections (n = 5). Cohorting was performed either simultaneously (56 of 87, 64.4%) or in phases (31 of 87, 35.6%) to help contain transmission. In 60 studies, both patients and staff were cohorted. Most studies (77 of 87, 88.5%) showed a decline in infection or colonization rates after a multifaceted approach that included cohorting as part of the intervention bundle. Hand hygiene compliance improved in approximately half of the studies (8 of 15) during the respective intervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X20000458_as4\" sec-type=\"other\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Cohorting of staff, patients, or both is a frequently used and reasonable component of an enhanced infection control strategy. However, determining the effectiveness of cohorting as a strategy to reduce transmission of MDRO and\n                      <jats:italic>C. difficile<\/jats:italic>\n                      infections is difficult, particularly in endemic situations.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/ice.2020.45","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T04:57:52Z","timestamp":1585285072000},"page":"691-709","source":"Crossref","is-referenced-by-count":25,"title":["A systematic review of the effectiveness of cohorting to reduce transmission of healthcare-associated\n                    <i>C. difficile<\/i>\n                    and multidrug-resistant organisms"],"prefix":"10.1017","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5183-8239","authenticated-orcid":false,"given":"Cybele 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