{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:53:42Z","timestamp":1789538022240,"version":"build-2803163510"},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T00:00:00Z","timestamp":1602460800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0899823X20004675_as1\"><jats:title>Objective:<\/jats:title><jats:p>To evaluate the effect of 70% isopropyl alcohol\u2013impregnated central venous catheter caps on ambulatory central-line\u2013associated bloodstream infections (CLABSIs) in pediatric hematology-oncology patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20004675_as2\"><jats:title>Design:<\/jats:title><jats:p>This study was a 24-month, cluster-randomized, 2 period, crossover clinical trial.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20004675_as3\"><jats:title>Setting:<\/jats:title><jats:p>The study was conducted in 15 pediatric healthcare institutions, including 16 pediatric hematology-oncology clinics.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20004675_as4\"><jats:title>Participants:<\/jats:title><jats:p>All patients with an external central line followed at 1 of the 16 hematology-oncology clinics.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20004675_as5\"><jats:title>Intervention:<\/jats:title><jats:p>Usual ambulatory central-line care per each institution using 70% isopropyl alcohol\u2013impregnated caps at home compared to usual ambulatory central-line care in each institution without using 70% isopropyl alcohol\u2013impregnated caps.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20004675_as6\"><jats:title>Results:<\/jats:title><jats:p>Of the 16 participating clinics, 15 clinics completed both assignment periods. As assigned, there was no reduction in CLABSI incidence in clinics using 70% isopropyl alcohol\u2013impregnated caps (1.23 per 1,000 days) compared with standard practices (1.38 per 1,000 days; adjusted incidence rate ratio [aIRR], 0.83; 95% CI, 0.63\u20131.11). In the per-protocol population, there was a reduction in positive blood culture incidence in clinics using 70% isopropyl alcohol-impregnated caps (1.51 per 1,000 days) compared with standard practices (1.88 per 1,000 days; aIRR, 0.72; 95% CI, 0.52\u20130.99). No adverse events were reported.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20004675_as7\"><jats:title>Conclusions:<\/jats:title><jats:p>Isopropyl alcohol\u2013impregnated central-line caps did not lead to a statistically significant reduction in CLABSI rates in ambulatory hematology-oncology patients. In the per-protocol analysis, there was a statistically significant decrease in positive blood cultures. Larger trials are needed to elucidate the impact of 70% isopropyl alcohol\u2013impregnated caps in the ambulatory setting.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X20004675_as8\"><jats:title>Registration:<\/jats:title><jats:p><jats:uri xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:uri>; NCT02351258<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2020.467","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T06:52:35Z","timestamp":1602485555000},"page":"431-439","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":12,"title":["Alcohol-impregnated caps and ambulatory central-line\u2013associated bloodstream infections (CLABSIs): A randomized clinical trial"],"prefix":"10.1017","volume":"42","author":[{"given":"Aaron M.","family":"Milstone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayane","family":"Yenokyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0380-8318","authenticated-orcid":false,"given":"Danielle W.","family":"Koontz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene R.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the CCLIP Authorship Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,10,12]]},"reference":[{"key":"S0899823X20004675_ref4","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26053"},{"key":"S0899823X20004675_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.java.2012.10.002"},{"key":"S0899823X20004675_ref17","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27978"},{"key":"S0899823X20004675_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2016.06.013"},{"key":"S0899823X20004675_ref5","first-page":"177","article-title":"Bringing central-line\u2013associated bloodstream infection prevention home: catheter maintenance practices and beliefs of pediatric oncology patients and families","volume":"41","author":"Rinke","year":"2015","journal-title":"Jt Comm J Qual Patient Saf"},{"key":"S0899823X20004675_ref12","doi-asserted-by":"publisher","DOI":"10.1191\/1740774504cn024oa"},{"key":"S0899823X20004675_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2012.01.025"},{"key":"S0899823X20004675_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2012.05.030"},{"key":"S0899823X20004675_ref15","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26194"},{"key":"S0899823X20004675_ref3","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24677"},{"key":"S0899823X20004675_ref14","unstructured":"14. 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Accessed Spetember 2020."},{"key":"S0899823X20004675_ref6","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-0302"},{"key":"S0899823X20004675_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2014.09.008"},{"key":"S0899823X20004675_ref1","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1093\/jnci\/djn276","article-title":"Trends in 5- and 10-year survival after diagnosis with childhood hematologic malignancies in the United States, 1990\u20132004","volume":"100","author":"Pulte","year":"2008","journal-title":"J Natl Cancer Inst"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X20004675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T14:24:51Z","timestamp":1618583091000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X20004675\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,12]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S0899823X20004675"],"URL":"https:\/\/doi.org\/10.1017\/ice.2020.467","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,12]]},"assertion":[{"value":"\u00a9 2020 by The Society for Healthcare Epidemiology of America. 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