{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:28:11Z","timestamp":1759091291916,"version":"3.40.5"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0899823X2100146X_as1\"><jats:title>Objective:<\/jats:title><jats:p>To determine clinical characteristics associated with false-negative severe acute respiratory coronavirus virus 2 (SARS-CoV-2) test results to help inform coronavirus disease 2019 (COVID-19) testing practices in the inpatient setting.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X2100146X_as2\"><jats:title>Design:<\/jats:title><jats:p>A retrospective observational cohort study.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X2100146X_as3\"><jats:title>Setting:<\/jats:title><jats:p>Tertiary-care facility.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X2100146X_as4\"><jats:title>Patients:<\/jats:title><jats:p>All patients 2 years of age and older tested for SARS-CoV-2 between March 14, 2020, and April 30, 2020, who had at least 2 SARS-CoV-2 reverse-transcriptase polymerase chain reaction tests within 7 days.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X2100146X_as5\"><jats:title>Methods:<\/jats:title><jats:p>The primary outcome measure was a false-negative testing episode, which we defined as an initial negative test followed by a positive test within the subsequent 7 days. Data collected included symptoms, demographics, comorbidities, vital signs, labs, and imaging studies. Logistic regression was used to model associations between clinical variables and false-negative SARS-CoV-2 test results.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X2100146X_as6\"><jats:title>Results:<\/jats:title><jats:p>Of the 1,009 SARS-CoV-2 test results included in the analysis, 4.0% were false-negative results. In multivariable regression analysis, compared with true-negative test results, false-negative test results were associated with anosmia or ageusia (adjusted odds ratio [aOR], 8.4; 95% confidence interval [CI], 1.4\u201350.5; <jats:italic>P<\/jats:italic> = .02), having had a COVID-19\u2013positive contact (aOR, 10.5; 95% CI, 4.3\u201325.4; <jats:italic>P<\/jats:italic> &lt; .0001), and having an elevated lactate dehydrogenase level (aOR, 3.3; 95% CI, 1.2\u20139.3; <jats:italic>P<\/jats:italic> = .03). Demographics, symptom duration, other laboratory values, and abnormal chest imaging were not significantly associated with false-negative test results in our multivariable analysis.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X2100146X_as7\"><jats:title>Conclusions:<\/jats:title><jats:p>Clinical features can help predict which patients are more likely to have false-negative SARS-CoV-2 test results.<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2021.146","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T03:00:22Z","timestamp":1618801222000},"page":"467-473","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Clinical characteristics of hospitalized patients with false-negative severe acute respiratory coronavirus virus 2 (SARS-CoV-2) test results"],"prefix":"10.1017","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0297-5998","authenticated-orcid":false,"given":"Erica L.","family":"MacKenzie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dariusz A.","family":"Hareza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maggie W.","family":"Collison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna E.","family":"Czapar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antigone K.","family":"Kraft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bennett J.","family":"Waxse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleanor E.","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica P.","family":"Ridgway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,4,19]]},"reference":[{"key":"S0899823X2100146X_ref1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00557-20"},{"key":"S0899823X2100146X_ref12","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00995-20"},{"key":"S0899823X2100146X_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26242"},{"key":"S0899823X2100146X_ref27","first-page":"e13","article-title":"SARS-CoV-2, SARS-CoV-1, and MERS-CoV viral load dynamics, duration of viral shedding and infectiousness: a living systematic review and meta-analysis","volume":"2","author":"Cevik","year":"2021","journal-title":"SSRN Electron J"},{"key":"S0899823X2100146X_ref16","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2020-0398"},{"key":"S0899823X2100146X_ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-06069-6"},{"key":"S0899823X2100146X_ref2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00821-20"},{"key":"S0899823X2100146X_ref22","first-page":"102581","article-title":"COVID-19 and anosmia: a review based on up-to-date knowledge","volume":"41","author":"Meng","year":"2020","journal-title":"Am J Otolaryngol - 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Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}