{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:30:16Z","timestamp":1780479016840,"version":"3.54.1"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T00:00:00Z","timestamp":1621209600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0899823X21001896_as1\"><jats:title>Objective:<\/jats:title><jats:p>To evaluate the impact of a vancomycin-resistant <jats:italic>Enterococcus<\/jats:italic> (VRE) screening policy change on the incidence of healthcare-associated (HA)-VRE bacteremia in an endemic hospital setting.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X21001896_as2\"><jats:title>Design:<\/jats:title><jats:p>A quasi-experimental before-and-after study.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X21001896_as3\"><jats:title>Setting:<\/jats:title><jats:p>A 1,989-bed tertiary-care referral center in Seoul, Republic of Korea.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X21001896_as4\"><jats:title>Methods:<\/jats:title><jats:p>Since May 2010, our hospital has diminished VRE screening for admitted patients transferred from other healthcare facilities. We assessed the impact of this policy change on the incidence of HA-VRE bacteremia using segmented autoregression analysis of interrupted time series from January 2006 to December 2014 at the hospital and unit levels. In addition, we compared the molecular characteristics of VRE blood isolates collected before and after the screening policy change using multilocus sequence typing and pulsed-field gel electrophoresis.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X21001896_as5\"><jats:title>Results:<\/jats:title><jats:p>After the VRE screening policy change, the incidence of hospital-wide HA-VRE bacteremia increased, although no significant changes of level or slope were observed. In addition, a significant slope change in the incidence of HA-VRE bacteremia (change in slope, 0.007; 95% CI, 0.001\u20130.013; <jats:italic>P<\/jats:italic> = .02) was observed in the hemato-oncology department. Molecular analysis revealed that various VRE sequence types appeared after the policy change and that clonally related strains became more predominant (increasing from 26.1% to 59.3%).<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X21001896_as6\"><jats:title>Conclusions:<\/jats:title><jats:p>The incidence of HA-VRE bacteremia increased significantly after VRE screening policy change, and this increase was mainly driven by high-risk patient populations. When planning VRE control programs in hospitals, different approaches that consider risk for severe VRE infection in patients may be required.<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2021.189","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T07:56:12Z","timestamp":1621238172000},"page":"603-608","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":16,"title":["The impact of vancomycin-resistant <i>Enterococcus<\/i> (VRE) screening policy change on the incidence of healthcare-associated VRE bacteremia"],"prefix":"10.1017","volume":"43","author":[{"given":"Sun Young","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Mee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doo Ryeon","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Rim","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myeong-A","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Jae","family":"Huh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam Yong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungmin","family":"Huh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol-In","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyong Ran","family":"Peck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,5,17]]},"reference":[{"key":"S0899823X21001896_ref10","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.10142"},{"key":"S0899823X21001896_ref11","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2016.235"},{"key":"S0899823X21001896_ref5","doi-asserted-by":"publisher","DOI":"10.1086\/502196"},{"key":"S0899823X21001896_ref13","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2015.310"},{"key":"S0899823X21001896_ref6","doi-asserted-by":"publisher","DOI":"10.1086\/502213"},{"key":"S0899823X21001896_ref12","doi-asserted-by":"publisher","DOI":"10.1086\/676860"},{"key":"S0899823X21001896_ref16","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa009"},{"key":"S0899823X21001896_ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1000373"},{"key":"S0899823X21001896_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2007.10.007"},{"key":"S0899823X21001896_ref18","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofw246"},{"key":"S0899823X21001896_ref1","doi-asserted-by":"publisher","DOI":"10.2807\/ese.13.47.19046-en"},{"key":"S0899823X21001896_ref14","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2016.156"},{"key":"S0899823X21001896_ref17","doi-asserted-by":"publisher","DOI":"10.1086\/342904"},{"key":"S0899823X21001896_ref4","doi-asserted-by":"publisher","DOI":"10.1086\/430909"},{"key":"S0899823X21001896_ref3","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2016.174"},{"key":"S0899823X21001896_ref8","first-page":"1571","article-title":"Universal glove and gown use and acquisition of antibiotic-resistant bacteria in the ICU: a randomized trial","volume":"310","author":"Harris","year":"2013","journal-title":"JAMA"},{"key":"S0899823X21001896_ref2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2761"},{"key":"S0899823X21001896_ref15","doi-asserted-by":"publisher","DOI":"10.9778\/cmajo.20160121"},{"key":"S0899823X21001896_ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-019-0647-7"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X21001896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T02:23:56Z","timestamp":1692325436000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X21001896\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,17]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S0899823X21001896"],"URL":"https:\/\/doi.org\/10.1017\/ice.2021.189","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,17]]},"assertion":[{"value":"\u00a9 The Author(s), 2021. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}