{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:39:02Z","timestamp":1790872742663,"version":"4.1.0"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0899823X21002324_as1\"><jats:title>Objective:<\/jats:title><jats:p>To determine the impact of a documented penicillin or cephalosporin allergy on the development of surgical site infections (SSIs).<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X21002324_as2\"><jats:title>Background:<\/jats:title><jats:p>Appropriate preoperative antibiotic prophylaxis reduces SSI risk, but documented antibiotic allergies influence the choice of prophylactic agents. Few studies have examined the relationship between a reported antibiotic allergy and risk of SSI and to what extent this relationship is modified by the antibiotic class given for prophylaxis.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X21002324_as3\"><jats:title>Methods:<\/jats:title><jats:p>We conducted a retrospective cohort study of adult patients undergoing coronary artery bypass, craniotomy, spinal fusion, laminectomy, hip arthroplasty and knee arthroplasty at 3 hospitals from July 1, 2013, to December 31, 2017. We built a multivariable logistic regression model to calculate the adjusted odds ratio (aOR) of developing an SSI among patients with and without patient-reported penicillin or cephalosporin allergies. We also examined effect measure modification (EMM) to determine whether surgical prophylaxis affected the association between reported allergy and SSI.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X21002324_as4\"><jats:title>Results:<\/jats:title><jats:p>We analyzed 39,972 procedures; 1,689 (4.2%) with a documented patient penicillin or cephalosporin allergy, and 374 (0.9%) resulted in an SSI. Patients with a reported penicillin or cephalosporin allergy were more likely to develop an SSI compared to patients who did not report an allergy to penicillin or cephalosporins (adjusted odds ratio, 3.26; 95% confidence interval, 2.71\u20133.93). Surgical prophylaxis did not have significant EMM on this association.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X21002324_as5\"><jats:title>Conclusions:<\/jats:title><jats:p>Patients who reported a penicillin or cephalosporin allergy had higher odds of developing an SSI than nonallergic patients. However, the increase in odds is not completely mediated by the type of surgical prophylaxis. Instead, a reported allergy may be a surrogate marker for a more complicated patient population.<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2021.232","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T09:40:55Z","timestamp":1623231655000},"page":"829-833","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":22,"title":["The impact of patient-reported penicillin or cephalosporin allergy on surgical site infections"],"prefix":"10.1017","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7117-513X","authenticated-orcid":false,"given":"Jessica L.","family":"Seidelman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekah W.","family":"Moehring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deverick J.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah S.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"key":"S0899823X21002324_ref14","unstructured":"14. National Healthcare Safety Network. Surgical Site Infection Event (SSI). Centers for Disease Control and Prevention website. https:\/\/www.cdc.gov\/nhsn\/pdfs\/pscmanual\/9pscssicurrent.pdf. Updated January 2018. Accessed December 23, 2020."},{"key":"S0899823X21002324_ref6","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.M.00663"},{"key":"S0899823X21002324_ref15","unstructured":"15. Duke Antimicrobial Stewardship Outreach Network (DASON). Duke University website. http:\/\/dason.medicine.duke.edu\/home. Accessed January 7, 2021."},{"key":"S0899823X21002324_ref13","doi-asserted-by":"publisher","DOI":"10.2298\/MPNS1402011R"},{"key":"S0899823X21002324_ref17","doi-asserted-by":"publisher","DOI":"10.1017\/S0899823X00193869"},{"key":"S0899823X21002324_ref18","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199901000-00008"},{"key":"S0899823X21002324_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31821175f8"},{"key":"S0899823X21002324_ref9","doi-asserted-by":"publisher","DOI":"10.5415\/apallergy.2013.3.2.115"},{"key":"S0899823X21002324_ref7","doi-asserted-by":"publisher","DOI":"10.1111\/all.12881"},{"key":"S0899823X21002324_ref22","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocv139"},{"key":"S0899823X21002324_ref19","doi-asserted-by":"crossref","first-page":"154","DOI":"10.37765\/ajmc.2020.42832","article-title":"High-cost, high-need patients: the impact of reported penicillin allergy","volume":"26","author":"Blumenthal","year":"2020","journal-title":"Am J Manag Care"},{"key":"S0899823X21002324_ref4","first-page":"195","article-title":"Clinical practice guidelines for antimicrobial prophylaxis in surgery","volume":"70(3)","author":"Bratzler","year":"2013","journal-title":"AJHP"},{"key":"S0899823X21002324_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(94)90129-5"},{"key":"S0899823X21002324_ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.9763"},{"key":"S0899823X21002324_ref20","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-D-18-00709"},{"key":"S0899823X21002324_ref8","doi-asserted-by":"publisher","DOI":"10.1086\/502212"},{"key":"S0899823X21002324_ref5","first-page":"263","article-title":"Prophylactic antibiotic management of surgical patients noted as \u201callergic\u201d to penicillin at two academic hospitals","volume":"6","author":"Epstein","year":"2015","journal-title":"Case Rept"},{"key":"S0899823X21002324_ref12","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815617129"},{"key":"S0899823X21002324_ref11","first-page":"861","article-title":"Clinical retrospective study of self-reported penicillin allergy on dental implant failures and infections","volume":"47","author":"French","year":"2016","journal-title":"Quintessence Int"},{"key":"S0899823X21002324_ref1","doi-asserted-by":"publisher","DOI":"10.1086\/673443"},{"key":"S0899823X21002324_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix794"},{"key":"S0899823X21002324_ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-015-4672-4"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X21002324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T09:14:38Z","timestamp":1657530878000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X21002324\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,9]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S0899823X21002324"],"URL":"https:\/\/doi.org\/10.1017\/ice.2021.232","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,9]]},"assertion":[{"value":"\u00a9 The Author(s), 2021. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}