{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:54:13Z","timestamp":1785884053976,"version":"3.56.0"},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0899823X21003299_as1\"><jats:title>Background:<\/jats:title><jats:p>Approximately 10% of patients report allergies to penicillin, yet &gt;90% of these allergies are not clinically significant. Patients reporting penicillin allergies are often treated with second-line, non\u2013\u03b2-lactam antibiotics that are typically broader spectrum and more toxic. Orders for \u03b2-lactam antibiotics for these patients trigger interruptive alerts, even when there is electronic health record (EHR) data indicating prior \u03b2-lactam exposure.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X21003299_as2\"><jats:title>Objective:<\/jats:title><jats:p>To describe the rate that interruptive penicillin allergy alerts display for patients who have previously had a \u03b2-lactam exposure.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X21003299_as3\"><jats:title>Design:<\/jats:title><jats:p>Retrospective EHR review from January 2013 through June 2018.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X21003299_as4\"><jats:title>Setting:<\/jats:title><jats:p>A nonprofit health system including 1 large tertiary-care medical center, a smaller associated hospital, 2 emergency departments, and \u02dc250 outpatient clinics.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X21003299_as5\"><jats:title>Participants:<\/jats:title><jats:p>All patients with EHR-documented of penicillin allergies.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X21003299_as6\"><jats:title>Methods:<\/jats:title><jats:p>We examined interruptive penicillin allergy alerts and identified the number and percentage of alerts that display for patients with a prior administration of a penicillin class or other \u03b2-lactam antibiotic.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X21003299_as7\"><jats:title>Results:<\/jats:title><jats:p>Of 115,081 allergy alerts that displayed during the study period, 8% were displayed for patients who had an inpatient administration of a penicillin antibiotic after the allergy was noted, and 49% were displayed for patients with a prior inpatient administration of any \u03b2-lactam.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X21003299_as8\"><jats:title>Conclusions:<\/jats:title><jats:p>Many interruptive penicillin allergy alerts display for patients who would likely tolerate a penicillin, and half of all alerts display for patients who would likely tolerate another \u03b2-lactam.<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2021.329","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T11:06:38Z","timestamp":1628852798000},"page":"1108-1111","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["Incidence of interruptive penicillin allergy alerts in patients with previously documented beta-lactam exposure: Potential for leveraging the electronic health record to identify erroneous allergies"],"prefix":"10.1017","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4057-2911","authenticated-orcid":false,"given":"Nicole","family":"Van Groningen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galen","family":"Cook-Wiens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Kwong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Sonesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teryl K.","family":"Nuckols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne L.","family":"Cassel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua M.","family":"Pevnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,8,13]]},"reference":[{"key":"S0899823X21003299_ref14","unstructured":"14. 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Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}