{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:08:40Z","timestamp":1791331720331,"version":"4.3.1"},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0899823X22001283_as1\"><jats:title>Objective:<\/jats:title><jats:p>To describe the clinical impact of healthcare-associated (HA) respiratory syncytial virus (RSV) in hospitalized adults.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X22001283_as2\"><jats:title>Design:<\/jats:title><jats:p>Retrospective cohort study within a prospective, population-based, surveillance study of RSV-infected hospitalized adults during 3 respiratory seasons: October 2017\u2013April 2018, October 2018\u2013April 2019, and October 2019\u2013March 2020.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X22001283_as3\"><jats:title>Setting:<\/jats:title><jats:p>The study was conducted in 2 academically affiliated medical centers.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X22001283_as4\"><jats:title>Patients:<\/jats:title><jats:p>Each HA-RSV patient (in whom RSV was detected by PCR test \u22654 days after hospital admission) was matched (age, sex, season) with 2 community-onset (CO) RSV patients (in whom RSV was detected \u22643 days of admission).<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X22001283_as5\"><jats:title>Methods:<\/jats:title><jats:p>Risk factors and outcomes were compared among HA-RSV versus CO-RSV patients using conditional logistic regression. Escalation of respiratory support associated with RSV detection (day 0) from day \u22122 to day +4 was explored among HA-RSV patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X22001283_as6\"><jats:title>Results:<\/jats:title><jats:p>In total, 84 HA-RSV patients were matched to 160 CO-RSV patients. In HA-RSV patients, chronic kidney disease was more common, while chronic respiratory conditions and obesity were less common. HA-RSV patients were not more likely to be admitted to an ICU or require mechanical ventilation, but they more often required a higher level of care at discharge compared with CO-RSV patients (44% vs 14%, respectively). Also, 29% of evaluable HA-RSV patients required respiratory support escalation; these patients were older and more likely to have respiratory comorbidities, to have been admitted to intensive care, and to die during hospitalization.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X22001283_as7\"><jats:title>Conclusions:<\/jats:title><jats:p>HA-RSV in adults may be associated with escalation in respiratory support and an increased level of support in living situation at discharge. Infection prevention and control strategies and RSV vaccination of high-risk adults could mitigate the risk of HA-RSV.<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2022.128","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T01:01:01Z","timestamp":1668387661000},"page":"433-439","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":23,"title":["Clinical impact of healthcare-associated respiratory syncytial virus in hospitalized adults"],"prefix":"10.1017","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2411-2712","authenticated-orcid":false,"given":"Alexandra","family":"Hill-Ricciuti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward E.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Greendyke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoonyoung","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Barrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Alba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela R.","family":"Branche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann R.","family":"Falsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyn","family":"Finelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7231-8451","authenticated-orcid":false,"given":"Lisa","family":"Saiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"key":"S0899823X22001283_ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-021-02064-6"},{"key":"S0899823X22001283_ref26","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.428"},{"key":"S0899823X22001283_ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043951"},{"key":"S0899823X22001283_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24521"},{"key":"S0899823X22001283_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2016.03.075"},{"key":"S0899823X22001283_ref19","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3389\/fmicb.2013.00293","article-title":"Virus-induced exacerbations in asthma and COPD","volume":"4","author":"Kurai","year":"2013","journal-title":"Front Microbiol"},{"key":"S0899823X22001283_ref5","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12823"},{"key":"S0899823X22001283_ref20","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit471"},{"key":"S0899823X22001283_ref2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/cid\/ciy991","article-title":"Severe morbidity and mortality associated with respiratory syncytial virus versus influenza infection in hospitalized older adults","volume":"69","author":"Ackerson","year":"2019","journal-title":"Clin Infect Dis"},{"key":"S0899823X22001283_ref6","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12696"},{"key":"S0899823X22001283_ref25","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix196"},{"key":"S0899823X22001283_ref15","doi-asserted-by":"crossref","unstructured":"15. Branche, AR , Saiman, L , Walsh, EE , et al. Incidence of respiratory syncytial virus among hospitalized adults, 2017\u20132020. 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Goldman, CR , Sieling, WD , Alba, LR , et al. Severe clinical outcomes among adults hospitalized with respiratory syncytial virus infections, New York City, 2017\u20132019. 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Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America.","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}