{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:32:34Z","timestamp":1793320354885,"version":"4.5.0"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0899823X22002045_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Candida auris<\/jats:italic>\n                      is an emerging fungal pathogen causing outbreaks in healthcare facilities. Five distinctive genomic clades exhibit clade-unique characteristics, highlighting the importance of real-time genomic surveillance and incorporating genotypic information to inform infection prevention practices and treatment algorithms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X22002045_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Both active and passive surveillance were used to screen hospitalized patients.\n                      <jats:italic>C. auris<\/jats:italic>\n                      polymerase chain reaction (PCR) assay on inguinal-axillary swabs was performed on high-risk patients upon admission. All clinical yeast isolates were identified to the species level.\n                      <jats:italic>C. auris<\/jats:italic>\n                      isolates were characterized by both phenotypic antifungal susceptibility tests and whole-genome sequencing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X22002045_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      From late 2019 to early 2022, we identified 45 patients with\n                      <jats:italic>C. auris<\/jats:italic>\n                      . Most had a tracheostomy or were from a facility with a known outbreak. Moreover, 7 patients (15%) were only identified through passive surveillance. Also, 8 (18%) of the patients had a history of severe COVID-19. The overall mortality was 18%. Invasive\n                      <jats:italic>C. auris<\/jats:italic>\n                      infections were identified in 13 patients (29%), 9 (69%) of whom had bloodstream infections. Patients with invasive infection were more likely to have a central line. All\n                      <jats:italic>C. auris<\/jats:italic>\n                      isolates were resistant to fluconazole but susceptible to echinocandins. Genomic analysis showed that 1 dominant clade-III lineage is circulating in Los Angeles, with very limited intrahost and interhost genetic diversity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X22002045_as4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      We have demonstrated that a robust\n                      <jats:italic>C. auris<\/jats:italic>\n                      surveillance program can be established using both active and passive surveillance, with multidisciplinary efforts involving the microbiology laboratory and the hospital epidemiology team. In Los Angeles County,\n                      <jats:italic>C. auris<\/jats:italic>\n                      strains are highly related and echinocandins should be used for empiric therapy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/ice.2022.204","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T03:31:26Z","timestamp":1662089486000},"page":"1093-1101","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":30,"title":["Clinical, microbiological, and genomic characteristics of clade-III\n                    <i>Candida auris<\/i>\n                    colonization and infection in southern California, 2019\u20132022"],"prefix":"10.1017","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7368-7403","authenticated-orcid":false,"given":"Annabelle","family":"de St. Maurice","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urvashi","family":"Parti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria E.","family":"Anikst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Harper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruel","family":"Mirasol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayrton J.","family":"Dayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omai B.","family":"Garner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavitha K.","family":"Prabaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9991-1178","authenticated-orcid":false,"given":"Shangxin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"key":"S0899823X22002045_ref12","unstructured":"12. Screening for Candida auris colonization. Centers for Disease Control and Prevention website. https:\/\/www.cdc.gov\/fungal\/candida-auris\/c-auris-screening.html. Published 2022. Accessed March 28, 2022, 2022."},{"key":"S0899823X22002045_ref3","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01503-19"},{"key":"S0899823X22002045_ref13","doi-asserted-by":"publisher","DOI":"10.3201\/eid2704.204361"},{"key":"S0899823X22002045_ref19","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofab452"},{"key":"S0899823X22002045_ref6","doi-asserted-by":"publisher","DOI":"10.3390\/jof7020140"},{"key":"S0899823X22002045_ref7","doi-asserted-by":"publisher","DOI":"10.3201\/eid2509.190686"},{"key":"S0899823X22002045_ref2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw691"},{"key":"S0899823X22002045_ref4","volume-title":"Candida auris","year":"2022"},{"key":"S0899823X22002045_ref9","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00007-19"},{"key":"S0899823X22002045_ref10","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02102-20"},{"key":"S0899823X22002045_ref5","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.03364-19"},{"key":"S0899823X22002045_ref8","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01624-18"},{"key":"S0899823X22002045_ref14","unstructured":"14. Candida auris. Los Angeles County Publish Health Department wesbite. http:\/\/publichealth.lacounty.gov\/acd\/Diseases\/CandidaAuris.htm. Published 2022. Accessed March 28, 2022, 2022."},{"key":"S0899823X22002045_ref16","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00921-17"},{"key":"S0899823X22002045_ref1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-17"},{"key":"S0899823X22002045_ref20","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7002e3"},{"key":"S0899823X22002045_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2022.02.022"},{"key":"S0899823X22002045_ref17","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix744"},{"key":"S0899823X22002045_ref18","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab562"},{"key":"S0899823X22002045_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30316-X"},{"key":"S0899823X22002045_ref15","first-page":"e177","article-title":"Effectiveness of ATP bioluminescence to assess hospital cleaning: a review","volume":"58","author":"Nante","year":"2017","journal-title":"J Prev Med Hyg"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X22002045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T04:08:30Z","timestamp":1690344510000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X22002045\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,2]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S0899823X22002045"],"URL":"https:\/\/doi.org\/10.1017\/ice.2022.204","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,2]]},"assertion":[{"value":"\u00a9 The Author(s), 2022. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}