{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T20:26:44Z","timestamp":1779913604232,"version":"3.53.1"},"reference-count":12,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2023,9]]},"abstract":"Abstract<\/jats:title>Objectives:<\/jats:title>To improve dissemination and accessibility of guidelines to healthcare providers at our institution, guidance for infectious syndromes was incorporated into an electronic application (e-app). The objective of this study was to compare empiric antimicrobial prescribing before and after implementation of the e-app.<\/jats:p><\/jats:sec>Design:<\/jats:title>This study was a before-and-after trial.<\/jats:p><\/jats:sec>Setting:<\/jats:title>A tertiary-care, public hospital in Halifax, Canada.<\/jats:p><\/jats:sec>Participants:<\/jats:title>This study included pediatric patients admitted to hospital who were empirically prescribed an antibiotic for an infectious syndrome listed in the e-app.<\/jats:p><\/jats:sec>Methods:<\/jats:title>Data were collected from medical records. Prescribing was independently assessed considering patient-specific characteristics using a standardized checklist by 2 members of the research team. Assessments of antimicrobial prescribing were compared, and discrepancies were resolved through discussion. Empiric antimicrobial prescribing before and after implementation of the e-app was compared using interrupted time-series analysis.<\/jats:p><\/jats:sec>Results:<\/jats:title>In total, 237 patients were included in the preimplementation arm and 243 patients were included in the postimplementation arm. Pneumonia (23.8%), appendicitis (19.2%), and sepsis (15.2%) were the most common indications for antimicrobial use. Empiric antimicrobial use was considered optimal in 195 (81.9%) of 238 patients before implementation compared to 226 (93.0%) 243 patients after implementation. An immediate 15.5% improvement (P<\/jats:italic> = .019) in optimal antimicrobial prescribing was observed following the implementation of the e-app.<\/jats:p><\/jats:sec>Conclusions:<\/jats:title>Empiric antimicrobial prescribing for pediatric patients with infectious syndromes improved after implementation of an e-app for dissemination of clinical practice guidelines. The use of e-apps may also be an effective strategy to improve antimicrobial use in other patient populations.<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2022.286","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T10:17:34Z","timestamp":1672741054000},"page":"1417-1422","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Evaluating the impact of incorporating clinical practice guidelines for the management of infectious diseases into an electronic application (e-app)"],"prefix":"10.1017","volume":"44","author":[{"given":"Holly M.","family":"MacKinnon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn L.","family":"Slayter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2132-674X","authenticated-orcid":false,"given":"Jeannette L.","family":"Comeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0626-7673","authenticated-orcid":false,"given":"Caroline","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8230-9807","authenticated-orcid":false,"given":"Emily K.","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,1,3]]},"reference":[{"key":"S0899823X22002860_ref5","doi-asserted-by":"publisher","DOI":"10.1155\/2006\/753083"},{"key":"S0899823X22002860_ref6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.15.1458"},{"key":"S0899823X22002860_ref10","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X1501500208"},{"key":"S0899823X22002860_ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7162.858"},{"key":"S0899823X22002860_ref2","unstructured":"2. Federal action plan on antimicrobial resistance and use in Canada. Public Health Agency of Canada website. https:\/\/www.canada.ca\/content\/dam\/canada\/health-canada\/migration\/healthy-canadians\/alt\/pdf\/publications\/drugs-products-medicaments-produits\/antibiotic-resistance-antibiotique\/action-plan-daction-eng.pdf. Published March 2016. Accessed March 9, 2017."},{"key":"S0899823X22002860_ref9","doi-asserted-by":"crossref","unstructured":"9. Black, E , MacKinnon, H , Slayter, K , Comeau, J , Timberlake, K , Science, M. Development of quality indicators to evaluate appropriate empiric antimicrobial use in pediatric patients. Can J Hosp Pharm 2022. [In Press].","DOI":"10.4212\/cjhp.3258"},{"key":"S0899823X22002860_ref11","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx040"},{"key":"S0899823X22002860_ref8","volume-title":"Methods and Applications","author":"Elseviers","year":"2016"},{"key":"S0899823X22002860_ref1","unstructured":"1. Antimicrobial resistance global report on surveillance. World Health Organization website. http:\/\/apps.who.int\/iris\/bitstream\/10665\/112642\/1\/9789241564748_eng.pdf?ua=1. Published 2014. Accessed March 4, 2017."},{"key":"S0899823X22002860_ref7","first-page":"263","article-title":"Healthcare provider\u2019s perceptions of antimicrobial use and stewardship at acute-care hospitals in Nova Scotia","volume":"72","author":"Black","year":"2019","journal-title":"Can J Hosp Pharm"},{"key":"S0899823X22002860_ref4","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq430"},{"key":"S0899823X22002860_ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0239751"}],"container-title":["Infection Control & Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X22002860","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T07:37:07Z","timestamp":1711957027000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X22002860\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,3]]},"references-count":12,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S0899823X22002860"],"URL":"https:\/\/doi.org\/10.1017\/ice.2022.286","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,3]]},"assertion":[{"value":"\u00a9 The Author(s), 2023. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}