{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:42:52Z","timestamp":1791420172746,"version":"4.3.3"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0899823X2200318X_as1\"><jats:title>Objective:<\/jats:title><jats:p>To evaluate the change in consumption of specific antibiotics in a neonatal intensive care unit after the implementation of an antimicrobial stewardship program (ASP).<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X2200318X_as2\"><jats:title>Design:<\/jats:title><jats:p>Retrospective cohort study between January 1, 2010, and December 31,2019.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X2200318X_as3\"><jats:title>Setting:<\/jats:title><jats:p>The neonatal intensive care unit at British Columbia\u00a0Women\u2019s Hospital (Vancouver Canada), a tertiary-care center.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X2200318X_as4\"><jats:title>Patients:<\/jats:title><jats:p>Admitted neonates prescribed antibiotics.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X2200318X_as5\"><jats:title>Methods:<\/jats:title><jats:p>We implemented an ASP with an early implementation phase starting in January 2014 (period 2) and a later phase starting in January 2017 (period 3). Patient demographics were collected, including birth weight, gestational age, history of necrotizing enterocolitis (NEC), and surgical operations from existing databases. Interrupted time-series analysis was used, and comparison of antibiotic days of therapy (DOT) averages were conducted across the preimplementation period (period 1), period 2, and period 3 regarding total patients and subgroups.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X2200318X_as6\"><jats:title>Results:<\/jats:title><jats:p>We identified 4,512 infants. There was a significant decrease in DOT from 472 (95% confidence interval [CI], 431\u2013517) in period 1 to 405 (95% CI, 367\u2013446) in period 2 to 313 (95% CI, 280\u2013350) in period 3. We detected a significant decrease in the use of ampicillin, aminoglycosides, cloxacillin, and linezolid but not in vancomycin or cefotaxime. Subgroup analyses of infants &lt;1,500 g and those without NEC or surgery showed decreases in the use of cloxacillin, aminoglycosides, and linezolid.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X2200318X_as7\"><jats:title>Conclusions:<\/jats:title><jats:p>The implementation of an ASP was associated with a significant decrease in the overall DOT and use of certain antibiotics. This study presents important targets for ongoing ASP work.<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2022.318","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T08:20:15Z","timestamp":1675412415000},"page":"1718-1724","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Effectiveness of a neonatal intensive care unit\u2013specific antimicrobial stewardship program: A ten-year review"],"prefix":"10.1017","volume":"44","author":[{"given":"Katrina H.","family":"Assen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Paquette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianne Y.","family":"Albert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginger","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0030-7665","authenticated-orcid":false,"given":"Jocelyn A.","family":"Srigley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5290-2565","authenticated-orcid":false,"given":"Horacio","family":"Osiovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley D.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5246-8823","authenticated-orcid":false,"given":"Joseph Y.","family":"Ting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,2,3]]},"reference":[{"key":"S0899823X2200318X_ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-019-1481-z"},{"key":"S0899823X2200318X_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.semperi.2020.151329"},{"key":"S0899823X2200318X_ref27","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-2286"},{"key":"S0899823X2200318X_ref10","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2017.183"},{"key":"S0899823X2200318X_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30205-5"},{"key":"S0899823X2200318X_ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.10244"},{"key":"S0899823X2200318X_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.semperi.2020.151322"},{"key":"S0899823X2200318X_ref8","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1632390"},{"key":"S0899823X2200318X_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000719"},{"key":"S0899823X2200318X_ref16","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.109608"},{"key":"S0899823X2200318X_ref23","doi-asserted-by":"publisher","DOI":"10.1159\/000511710"},{"key":"S0899823X2200318X_ref24","doi-asserted-by":"publisher","DOI":"10.1136\/bmjoq-2017-000285"},{"key":"S0899823X2200318X_ref20","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2017.151"},{"key":"S0899823X2200318X_ref26","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-0589"},{"key":"S0899823X2200318X_ref14","first-page":"343","article-title":"CDC\u2019s campaign to prevent antimicrobial resistance in health-care settings","volume":"51","year":"2002","journal-title":"Morb Mortal Wkly Rep"},{"key":"S0899823X2200318X_ref11","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2019-318026"},{"key":"S0899823X2200318X_ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00027"},{"key":"S0899823X2200318X_ref29","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-1942"},{"key":"S0899823X2200318X_ref25","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-3956"},{"key":"S0899823X2200318X_ref12","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2012.06.005"},{"key":"S0899823X2200318X_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2010.11.011"},{"key":"S0899823X2200318X_ref15","unstructured":"15. 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Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}