{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:52:35Z","timestamp":1791597155910,"version":"4.3.4"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0899823X24001326_as1\"><jats:title>Objective:<\/jats:title><jats:p>We aimed to describe the\u00a0incidence, pathogens, and antimicrobial susceptibility of central line-associated bloodstream infections (CLABSI) in adult intensive care units (ICU).<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X24001326_as2\"><jats:title>Design:<\/jats:title><jats:p>State surveillance data from 2011 to 2022 were analyzed to identify patient and device days and CLABSI events. Pathogen data were analyzed to determine the\u00a0most common organisms and patterns of antimicrobial resistance grouped into 3-year time epochs.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X24001326_as3\"><jats:title>Setting:<\/jats:title><jats:p>Adult ICU in Victoria, Australia.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X24001326_as4\"><jats:title>Participants:<\/jats:title><jats:p>Healthcare organizations participating in CLABSI state surveillance.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X24001326_as5\"><jats:title>Results:<\/jats:title><jats:p>608 events were reported over 751,350 device days. Overall, CLABSI incidence was 0.81 per 1,000 central-line days, with a 49.3% rate reduction from 2011 to 2022 (1.39 to 0.70 per 1,000 central-line days). Overall device utilization ratio was 0.57, with a 15.4% reduction from 2011 to 2022 (0.67 vs 0.56). Of 690 pathogens, the most common by rank order were coagulase-negative Staphylococci (CNS), <jats:italic>Candida<\/jats:italic> species, <jats:italic>Staphylococcus aureus<\/jats:italic>, and <jats:italic>Enterococcus faecalis<\/jats:italic>. The proportion of CNS-causing events increased by\u00a069.0% from 2011 to 2022; this trend was not observed for other organisms. For every increase in epoch, a 33% decrease in methicillin-resistant <jats:italic>S. aureus<\/jats:italic> (MRSA), 4% increase in vancomycin-resistant <jats:italic>Enterococcus faecium<\/jats:italic>, and 12% increase in ceftriaxone-resistant <jats:italic>Escherichia coli<\/jats:italic> pathogens were observed.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X24001326_as6\"><jats:title>Conclusions:<\/jats:title><jats:p>We demonstrate a decreasing incidence of CLABSI in Victorian adult ICU and an increasing burden of infections due to CNS. No significant time trend increases in antimicrobial-resistant organisms, including MRSA, vancomycin-resistant <jats:italic>E. faecium<\/jats:italic>, and ceftriaxone-resistant <jats:italic>E. coli<\/jats:italic> were observed. These findings are relevant for identifying priorities for CLABSI prevention in Victorian adult ICU.<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2024.132","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T07:33:34Z","timestamp":1730964814000},"page":"1378-1384","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Antimicrobial-resistant central line-associated bloodstream infections in adult intensive care units: findings from an Australian surveillance network, 2011\u20132022"],"prefix":"10.1017","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1782-7875","authenticated-orcid":false,"given":"Lyn-li","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang Wei Esther","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6586-1272","authenticated-orcid":false,"given":"Michael J.","family":"Malloy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Bull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Brett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon J.","family":"Worth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"S0899823X24001326_ref13","unstructured":"13. The Centre. Funded Organisation Performance Monitoring Framework. https:\/\/www.cfecfw.asn.au\/funded-organisation-performance-monitoring-framework\/. Published 2016. Accessed October 11, 2023."},{"key":"S0899823X24001326_ref22","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.19709"},{"key":"S0899823X24001326_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00409-0"},{"key":"S0899823X24001326_ref12","unstructured":"12. Current HAI Progress Report. U.S. Centers for Disease Control and Prevention website. https:\/\/www.cdc.gov\/healthcare-associated-infections\/php\/data\/progress-report.html?CDC_AAref_Val=https:\/\/www.cdc.gov\/hai\/data\/portal\/progress-report.html. Published 2024. Accessed May 23, 2024."},{"key":"S0899823X24001326_ref7","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2019.303"},{"key":"S0899823X24001326_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(22)00274-1"},{"key":"S0899823X24001326_ref20","unstructured":"20. European Centre for Disease Prevention and Control. Healthcare-associated infections acquired in intensive care units. In: ECDC. Annual epidemiological report for 2017. Stockholm: ECDC;2019. https:\/\/www.ecdc.europa.eu\/en\/publications-data\/healthcare-associated-infections-intensive-care-units-annual-epidemiological-1. Published 2019. Accessed March 5, 2024."},{"key":"S0899823X24001326_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2017.02.010"},{"key":"S0899823X24001326_ref19","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2019.296"},{"key":"S0899823X24001326_ref14","doi-asserted-by":"publisher","DOI":"10.5694\/mja14.01644"},{"key":"S0899823X24001326_ref11","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.51318"},{"key":"S0899823X24001326_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2015.03.036"},{"key":"S0899823X24001326_ref9","unstructured":"9. Centers for Disease Control and Prevention. The National Health Safety Network (NHSN) Manual: Patient Safety Component. Atlanta, GA: Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infection Diseases. https:\/\/www.cdc.gov\/nhsn\/acute-care-hospital\/index.html. Published 2023. Accessed October 11, 2023."},{"key":"S0899823X24001326_ref21","unstructured":"21. Australian Commission on Safety and Quality in Health Care. AURA 2023 The fifth Australian report on antimicrobial use and resistance in human health. https:\/\/www.safetyandquality.gov.au\/publications-and-resources\/resource-library\/aura-2023-fifth-australian-report-antimicrobial-use-and-resistance-human-health-report. Published 2023. Accessed March 5, 2024."},{"key":"S0899823X24001326_ref6","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50612"},{"key":"S0899823X24001326_ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06871-5"},{"key":"S0899823X24001326_ref4","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu239"},{"key":"S0899823X24001326_ref1","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2022.87"},{"key":"S0899823X24001326_ref2","unstructured":"2. Resar, R , Griffin, FA , Haraden, C , Nolan, TW. Using Care Bundles to Improve Health Care Quality. IHI Innovation Series white paper. Cambridge, Massachusetts: Institute for Healthcare Improvement. https:\/\/www.ihi.org\/resources\/white-papers\/using-care-bundles-improve-health-care-quality. Published 2012. Accessed March 5, 2024."},{"key":"S0899823X24001326_ref15","unstructured":"15. Central Line Insertion and Maintenance Guideline. Australian New Zealand Intensive Care Society website. https:\/\/www.anzics.org\/clabsi\/. Published 2012. Accessed 14 June, 2024"},{"key":"S0899823X24001326_ref10","volume-title":"Stata Statistical Software: Release 18","year":"2023"},{"key":"S0899823X24001326_ref18","doi-asserted-by":"publisher","DOI":"10.1086\/671724"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X24001326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T13:03:07Z","timestamp":1738846987000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X24001326\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,7]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S0899823X24001326"],"URL":"https:\/\/doi.org\/10.1017\/ice.2024.132","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,7]]},"assertion":[{"value":"\u00a9 The Author(s), 2024. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}