{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:05:54Z","timestamp":1770836754736,"version":"3.50.1"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0899823X24001557_as1\"><jats:title>Background:<\/jats:title><jats:p>Reducing rehospitalization has been a primary focus of hospitals and payors. Recurrence of <jats:italic>Clostridioides difficile<\/jats:italic> infection (CDI) is common and often results in rehospitalization. Factors that influence rehospitalization for CDI are not well understood.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X24001557_as2\"><jats:title>Objective:<\/jats:title><jats:p>To determine the risk factors that influence rehospitalization caused by CDI.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X24001557_as3\"><jats:title>Design:<\/jats:title><jats:p>A retrospective cohort study from January 1, 2018, to December 31, 2018, of patients aged \u226518 who tested positive for <jats:italic>C. difficile<\/jats:italic> while hospitalized.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X24001557_as4\"><jats:title>Setting:<\/jats:title><jats:p>Academic hospital.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X24001557_as5\"><jats:title>Methods:<\/jats:title><jats:p>The risk of rehospitalization was assessed across exposures during and after the index hospitalization using a Cox proportional hazards model. The primary outcome of this study was 60-day CDI-related rehospitalization.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X24001557_as6\"><jats:title>Results:<\/jats:title><jats:p>There were 559 hospitalized patients with a positive CD test during the study period, and 408 patients were included for analysis. All-cause rehospitalization was 46.1% within 60 days of the index hospital discharge. Within 60 days of discharge, 68 patients developed CDI, of which 72.5% (49 of 68) were rehospitalized specifically for the management of CDI. The risk of rehospitalization in patients with CDI was higher among patients who were exposed to systemic antibiotics ([adjusted hazard ratio] aHR: 2.78; 95% CI, 1.36\u20135.64) and lower among patients who had post-discharge follow-up addressing <jats:italic>C. difficile<\/jats:italic> (aHR: 0.53; 95% CI, 0.28\u20130.98).<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X24001557_as7\"><jats:title>Conclusions:<\/jats:title><jats:p>Exposure to systemic antibiotics increased the risk of rehospitalization due to CDI, while post-discharge follow-up decreased the risk of rehospitalization due to CDI. Comprehensive transitions of care for hospitalized patients with <jats:italic>C. difficile<\/jats:italic> may reduce the risk of CDI-related rehospitalization.<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2024.155","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T12:47:30Z","timestamp":1728564450000},"page":"1293-1299","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Risk of rehospitalization due to <i>Clostridioides difficile<\/i> infection among hospitalized patients with <i>Clostridioides difficile<\/i>: a cohort study"],"prefix":"10.1017","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4039-867X","authenticated-orcid":false,"given":"Emily N.","family":"Drwiega","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9548-229X","authenticated-orcid":false,"given":"Stuart","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry H.","family":"Danziger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9452-9316","authenticated-orcid":false,"given":"Andrew M.","family":"Skinner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"S0899823X24001557_ref8","first-page":"50495","article-title":"Medicare program; 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