{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T19:39:17Z","timestamp":1777318757878,"version":"3.51.4"},"reference-count":39,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0899823X24000199_as1\"><jats:title>Objectives:<\/jats:title><jats:p>Monitoring antibiotic consumption is a key component to steer antimicrobial stewardship programs, including in nursing homes. We analyzed changes in antibiotic consumption in French nursing homes during 5 years, including the COVID-19 pandemic, to identify potential priorities for improvement.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X24000199_as2\"><jats:title>Design:<\/jats:title><jats:p>A multicenter survey was conducted between 2018 and 2022.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X24000199_as3\"><jats:title>Setting:<\/jats:title><jats:p>The study was conducted across 220 French nursing homes with on-site pharmacies.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X24000199_as4\"><jats:title>Method:<\/jats:title><jats:p>Antibiotic consumption data were collected from pharmacy records and are expressed as defined daily doses per 1,000 resident days. Antibiotic indicators promoted by health authorities were calculated from quantitative data to evaluate the quality of prescribing.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X24000199_as5\"><jats:title>Results:<\/jats:title><jats:p>Antibiotic consumption significantly decreased between 2018 and 2022, particularly during the coronavirus disease 2019 (COVID-19) pandemic, despite a slight increase in 2022. During the study period, the most used antibiotic classes were penicillins (61.9% in 2022) followed by cephalosporins (10.5%), macrolides\u2013lincosamides\u2013streptogramins (7.3%) then fluoroquinolones (7.0%). Amoxicillin\u2013clavulanic acid was the most consumed antibiotic; amoxicillin and ceftriaxone ranked second and third. Azithromycin consumption increased from 2020, as did the indicator regarding broad-spectrum antibiotics.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X24000199_as6\"><jats:title>Conclusions:<\/jats:title><jats:p>The decreasing trend in antibiotic use and control of fluoroquinolone use over the study period suggest compliance with antibiotic use guidelines. However, changes in the use of broad-spectrum antibiotics and the substantial use of amoxicillin-clavulanic acid, although it is rarely a first-line antibiotic, highlight the need for antimicrobial stewardship activities and the usefulness of antibiotic consumption surveillance to identify priorities.<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2024.19","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T06:56:26Z","timestamp":1708325786000},"page":"740-745","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Antibiotic consumption in French nursing homes between 2018 and 2022: A multicenter survey"],"prefix":"10.1017","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9016-7766","authenticated-orcid":false,"given":"S\u00e9gol\u00e8ne","family":"Bouges","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Am\u00e9lie","family":"Jouzeau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Lieutier-Colas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muriel","family":"P\u00e9fau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lory","family":"Dugravot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Marie","family":"Rogues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loic","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1146-0259","authenticated-orcid":false,"given":"Catherine","family":"Dumartin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"key":"S0899823X24000199_ref18","doi-asserted-by":"publisher","DOI":"10.1093\/jacamr\/dlaa093"},{"key":"S0899823X24000199_ref24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0256501"},{"key":"S0899823X24000199_ref13","doi-asserted-by":"publisher","DOI":"10.1093\/jacamr\/dlad037"},{"key":"S0899823X24000199_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/S2589-7500(23)00108-5"},{"key":"S0899823X24000199_ref28","unstructured":"28. Disabling and potentially permanent side effects lead to suspension or restrictions of quinolone and fluoroquinolone antibiotics. European Medicines Agency website. https:\/\/www.ema.europa.eu\/en\/news\/disabling-potentially-permanent-side-effects-lead-suspension-restrictions-quinolone-fluoroquinolone. Published 2018. Accessed August 29, 2023."},{"key":"S0899823X24000199_ref6","unstructured":"6. National strategy for preventing infections and antibiotic resistance, 2022\u20132025. Minist\u00e8re des solidarit\u00e9s et de la sant\u00e9 website. https:\/\/sante.gouv.fr\/IMG\/pdf\/national_strategy_for_preventing_infections_and_antibiotic_resistance_2022-2025_.pdf. Published 2022. Accessed August 29, 2023."},{"key":"S0899823X24000199_ref8","unstructured":"8. Core elements of antibiotic stewardship for nursing homes. Centers for Disease Control and Prevention website. https:\/\/www.cdc.gov\/antibiotic-use\/core-elements\/nursing-homes.html. Updated 2021. 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Accessed August 29, 2023."}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X24000199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T08:34:00Z","timestamp":1715934840000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X24000199\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,19]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S0899823X24000199"],"URL":"https:\/\/doi.org\/10.1017\/ice.2024.19","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,19]]},"assertion":[{"value":"\u00a9 The Author(s), 2024. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}