{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T10:11:12Z","timestamp":1742379072288,"version":"3.40.1"},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0899823X24002101_as1\"><jats:title>Objective:<\/jats:title><jats:p>We aimed to determine whether benchmarking antimicrobial use (AU) to antimicrobial resistance (AR) using select AU\/AR ratios is more informative than AU metrics in isolation.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X24002101_as2\"><jats:title>Design:<\/jats:title><jats:p>We retrospectively measured AU (antimicrobial therapy days per 1,000 days present) and AU\/AR ratios (specific antimicrobial therapy days per corresponding AR event) in two hospitals during 2020 through 2022. We then had antimicrobial stewardship committee members evaluate each AU and corresponding AU\/AR value and indicate whether they believed it represented potential overuse, appropriate use, or potential underuse of the antimicrobials, or whether they could not provide an assessment.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X24002101_as3\"><jats:title>Setting:<\/jats:title><jats:p>Two acute-care hospitals.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X24002101_as6\"><jats:title>Patients:<\/jats:title><jats:p>Hospitalized patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X24002101_as4\"><jats:title>Results:<\/jats:title><jats:p>In semi-annual facility-wide analyses, echinocandins had a median AU\/AR ratio of 658.5 therapy days per fluconazole-resistant <jats:italic>Candida<\/jats:italic> event in Hospital A, IV vancomycin had a median AU\/AR ratio of 114.9 and 108.2 therapy days per methicillin-resistant <jats:italic>Staphylococcus aureus<\/jats:italic> event in Hospital A and B, respectively, and linezolid had a median AU\/AR ratio of 33.8 and 88.0 therapy days per vancomycin-resistant <jats:italic>Enterococcus<\/jats:italic> event in Hospital A and B, respectively. When AU and AU\/AR values were evaluated by stewardship committees, more respondents were able to assess antimicrobial use based on AU\/AR values compared to AU values. Based on AU\/AR ratios, most respondents identified potential overuse of echinocandins and IV vancomycin in Hospital A, and potential overuse of linezolid and IV vancomycin in Hospital B.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X24002101_as5\"><jats:title>Conclusion:<\/jats:title><jats:p>Select AU\/AR ratios provided informative metrics to antimicrobial stewardship personnel, which can be used to motivate audits of antimicrobial administration to determine appropriateness.<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2024.210","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T07:21:06Z","timestamp":1737962466000},"page":"281-288","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Benchmarking antimicrobial use to antimicrobial resistance: a comparative study of two hospitals using current National Healthcare Safety Network (NHSN) 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