{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:01:59Z","timestamp":1789952519379,"version":"4.0.1"},"reference-count":40,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0899823X25102432_as1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      In\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      the\n                      <jats:italic>qacA\/B<\/jats:italic>\n                      and\n                      <jats:italic>smr<\/jats:italic>\n                      genes have been associated with elevated MICs to antiseptics with such organisms often termed antiseptic tolerant\n                      <jats:italic>S. aureus<\/jats:italic>\n                      (ATSA). The impact of repeated healthcare or antiseptic exposure on colonization with ATSA is uncertain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25102432_as2\">\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Prospective longitudinal cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25102432_as3\">\n                    <jats:title>Setting\/Participants:<\/jats:title>\n                    <jats:p>The high-risk cohort included children with a new diagnosis of malignancy recruited from a pediatric oncology clinic. The low-risk cohort were otherwise healthy children enrolled from general pediatrics clinics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25102432_as4\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Subjects had anterior nares and axillary cultures collected at 3-month intervals for one year. Identified\n                      <jats:italic>S. aureus<\/jats:italic>\n                      isolates underwent PCR for\n                      <jats:italic>qacA\/B<\/jats:italic>\n                      and\n                      <jats:italic>smr<\/jats:italic>\n                      . The primary outcome was colonization with ATSA at least once during study follow-up. Logistic regression models were utilized to adjust for confounding across cohorts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25102432_as5\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>226 subjects were evaluable for the primary outcome. It was noted that 93.5% of high-risk subjects reported regularly using chlorhexidine gluconate (CHG) antiseptic products. Colonization with ATSA was found in 15.5% of subjects. In univariable analyses, subjects in the low-risk cohort more frequently had ATSA colonization; following adjustment for confounders, the rates of overall ATSA colonization were similar in the high- and low-risk cohorts. Only 2 subjects had colonization with an ATSA strain at more than one encounter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25102432_as6\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Pediatric oncology patients do not experience higher rates of ATSA colonization than healthy children. In addition, ATSA colonization is transient relative to strains negative for\n                      <jats:italic>smr<\/jats:italic>\n                      \/\n                      <jats:italic>qacA\/B<\/jats:italic>\n                      . These findings suggest that repeated use of infection prevention strategies including CHG do not predispose to colonization with ATSA in the ambulatory setting.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/ice.2025.10243","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T06:34:17Z","timestamp":1757572457000},"page":"999-1005","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Colonization with antiseptic tolerant\n                    <i>Staphylococcus aureus<\/i>\n                    in children with cancer: a longitudinal study"],"prefix":"10.1017","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0232-7491","authenticated-orcid":false,"given":"J Chase","family":"McNeil","sequence":"first","affiliation":[{"name":"Baylor College of Medicine"},{"name":"Baylor College of 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