{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:03:08Z","timestamp":1789952588945,"version":"4.0.1"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0899823X25102468_as1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Catheter-related bloodstream infections (CRBSI) or central line-associated bloodstream infections (CLABSI) occur frequently with long-term indwelling catheters. EDTA (Ethylenediaminetetraacetic acid) and other catheter lock solutions can prevent CRBSI\/CLABSI. This study aimed to identify the role of EDTA lock solution in preventing CRBSI\/CLABSI compared to the non-EDTA lock solutions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25102468_as2\">\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Eligible studies comparing the effectiveness of EDTA versus a control group on averting CRBSI or CLABSI were identified through searches across PubMed, Embase, Scopus, Cochrane CENTRAL, medRxiv, bioRxiv, and ClinicalTrials.gov. The secondary outcomes were catheter colonization, catheter survival, and catheter thrombosis. The relative risk for all the outcomes was calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25102468_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      This meta-analysis included eight studies (403 EDTA vs 425 control patients) and demonstrated a significant reduction in CRBSI\/CLABSI with EDTA (15 vs 71 events; RR: 0.18; 95% CI: 0.10\u20130.33;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.00001). Catheter colonization also decreased significantly (8 vs 38 events; OR: 0.11; 95% CI: 0.05\u20130.29). EDTA improved catheter survival in hemodialysis patients (OR: 3.77; 95% CI: 1.23\u201311.61;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.02) but showed no significant effect on thrombolytic treatment or all-cause mortality. Subgroup analyses supported these findings, with no publication bias detected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25102468_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>EDTA significantly reduces CRBSI\/CLABSI and catheter colonization, improves catheter survival, but does not affect thrombolytic treatment or mortality. Evidence certainty varies across outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/ice.2025.10246","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T09:18:19Z","timestamp":1757063899000},"page":"1035-1042","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Role of EDTA lock solution in preventing catheter-related bloodstream infections or central line-associated bloodstream infections: a systematic review and meta-analysis"],"prefix":"10.1017","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7854-6519","authenticated-orcid":false,"given":"Sayan","family":"Chakraborty","sequence":"first","affiliation":[{"name":"Manipal Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4139-1039","authenticated-orcid":false,"given":"Sanjay","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Tata Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9901-1572","authenticated-orcid":false,"given":"Abhinaba","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Tata Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5291-1901","authenticated-orcid":false,"given":"Soumyadip","family":"Chatterji","sequence":"additional","affiliation":[{"name":"Tata Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,9,5]]},"reference":[{"key":"S0899823X25102468_ref11","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy840"},{"key":"S0899823X25102468_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2011.07.035"},{"key":"S0899823X25102468_ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000328976"},{"key":"S0899823X25102468_ref8","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.7.3073-3076.2004"},{"key":"S0899823X25102468_ref20","doi-asserted-by":"publisher","DOI":"10.1086\/342905"},{"key":"S0899823X25102468_ref18","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0b013e31828d4610"},{"key":"S0899823X25102468_ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0231110"},{"key":"S0899823X25102468_ref23","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl234"},{"key":"S0899823X25102468_ref16","first-page":"154","article-title":"Comparative efficacy of various antimicrobial lock solutions for preventing catheter-related bloodstream infections: A network meta-analysis of 9099 patients from 52 randomized controlled trials","volume":"87","author":"Dang","year":"2019","journal-title":"Int J Infect Dis IJID Off Publ Int Soc Infect Dis"},{"key":"S0899823X25102468_ref21","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.3.641-646.1997"},{"key":"S0899823X25102468_ref1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02565-15"},{"key":"S0899823X25102468_ref9","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010121306"},{"key":"S0899823X25102468_ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.04.047"},{"key":"S0899823X25102468_ref19","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.009761-0"},{"key":"S0899823X25102468_ref14","doi-asserted-by":"publisher","DOI":"10.1086\/344952"},{"key":"S0899823X25102468_ref17","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-1645"},{"key":"S0899823X25102468_ref3","first-page":"1079","article-title":"Systematic review and meta-analysis of antibiotic and antimicrobial lock solutions for prevention of hemodialysis catheter-related infections","volume":"67","author":"Abdul Salim","year":"2021","journal-title":"ASAIO J Am Soc Artif Intern Organs 1992"},{"key":"S0899823X25102468_ref4","unstructured":"4. Baang, JH , Inagaki, K , Nagel, J , et al. Inpatient Diagnosis and Treatment of Catheter-Related Bloodstream Infection [Internet]. Ann Arbor (MI): Michigan Medicine University of Michigan; 2023 [cited 2024 Sep 26]. (Michigan Medicine Clinical Care Guidelines). Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK589895\/"},{"key":"S0899823X25102468_ref5","doi-asserted-by":"publisher","DOI":"10.1086\/502578"},{"key":"S0899823X25102468_ref7","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.11.3580-3585.2003"},{"key":"S0899823X25102468_ref12","doi-asserted-by":"publisher","DOI":"10.1177\/1129729820946916"},{"key":"S0899823X25102468_ref13","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.06.012"},{"key":"S0899823X25102468_ref22","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1155699"},{"key":"S0899823X25102468_ref15","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12492"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X25102468","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:51:52Z","timestamp":1789951912000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X25102468\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,5]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0899823X25102468"],"URL":"https:\/\/doi.org\/10.1017\/ice.2025.10246","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,5]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. 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