{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:02:33Z","timestamp":1789952553517,"version":"4.0.1"},"reference-count":39,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0899823X25102511_as1\">\n                    <jats:title>Background and objectives:<\/jats:title>\n                    <jats:p>Enhanced environmental disinfection is linked to reduced hospital-acquired infection rates. In this study, we aimed to evaluate the efficacy of an emerging disinfection technology, a filtered far-UV-C handheld (FFUHH) device, for reducing bacterial loads on high-touch surfaces in shared clinical workrooms, and to isolate, identify and characterize clinically significant environmental pathogens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25102511_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We compared samples from high-touch items (dictation device, mouse, armchair, desk, and keyboard) before and after FFUHH treatment. Samples were collected weekly: contact plates for colony counts and swabs before and after intervention on standardized adjacent areas for each surface, respectively. The swabs were enriched and cultured on selective media to isolate pathogens. Environmental samples, as well as clinical samples collected from patients during the study period, were validated using MALDI-TOF and whole genome sequencing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25102511_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among the 440 collected plates (220 before and 220 after treatment), the highest mean colony count pre-treatment was detected from armchairs, and the lowest from keyboards. The mean reduction of colony-forming units ranged 53% and 83% and was statistically significant (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05) across all surfaces except for the keyboard. We characterized multidrug-resistant\n                      <jats:italic>Staphylococcus epidermidis<\/jats:italic>\n                      ST5 and ST16 strains, a carbapenem-resistant\n                      <jats:italic>Acinetobacter baumannii,<\/jats:italic>\n                      and a\n                      <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                      genetically related to a clinical isolate with a rare sequence type not previously detected in our institution.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25102511_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The FFUHH effectively reduced the microbial burden on high-touch surfaces. It can offer an advantage for surface disinfection and an alternative to routinely used biocides.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/ice.2025.10251","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T09:17:02Z","timestamp":1757063822000},"page":"1027-1034","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["The efficacy of a filtered handheld far-ultraviolet disinfection device for decontamination of high-touch surfaces in healthcare settings: a genomic bacterial analysis"],"prefix":"10.1017","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6022-1890","authenticated-orcid":false,"given":"Layale","family":"Yaghi","sequence":"first","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy F","family":"Chemaly","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Wilson-Dib","sequence":"additional","affiliation":[{"name":"The University of Oklahoma College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8556-3248","authenticated-orcid":false,"given":"William C.","family":"Shropshire","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry","family":"Cantu","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micah","family":"Bhatti","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer 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Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}