{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T11:25:16Z","timestamp":1774783516785,"version":"3.50.1"},"reference-count":8,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We evaluated the impact of silencing penicillin cross-reactivity alerts on perioperative antibiotic prescribing and surgical site infections (SSIs) in 6 hospitals using an interrupted time series analysis. Silencing the alerts minimally increased cefazolin prescribing among penicillin allergy labeled patients (sensitivity analysis only;\n                    <jats:italic>P<\/jats:italic>\n                    = 0.03) and had no influence on SSIs (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.32).\n                  <\/jats:p>","DOI":"10.1017\/ice.2025.10311","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T12:39:13Z","timestamp":1759149553000},"page":"1265-1267","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Impact of silencing automated penicillin cross-reactivity alerts on perioperative antibiotic prescribing and surgical site infection rates"],"prefix":"10.1017","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4652-7089","authenticated-orcid":false,"given":"Michael J.","family":"Durkin","sequence":"first","affiliation":[{"name":"Washington University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9644-501X","authenticated-orcid":false,"given":"Joshua","family":"Nordman","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Bewley","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Marschall","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine"},{"name":"University of Arizona College of Medicine \u2013 Phoenix"},{"name":"BJC Healthcare"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Newland","sequence":"additional","affiliation":[{"name":"BJC Healthcare"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4773-9817","authenticated-orcid":false,"given":"Kimberly G.","family":"Blumenthal","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Harvard Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"S0899823X25103115_ref6","first-page":"1","article-title":"Perioperative cefazolin prescribing rates following suppression of alerts for non-IgE-mediated penicillin allergies","author":"Bogus","year":"2024","journal-title":"Infect Control Hosp Epidemiol"},{"key":"S0899823X25103115_ref7","first-page":"1893","article-title":"Suppressing the penicillin-cephalosporin allergy cross-reactivity alert: safety and impact on cephalosporin prescribing","volume":"10","author":"Russel","year":"2023","journal-title":"Open Forum Infect Dis"},{"key":"S0899823X25103115_ref4","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.8367"},{"key":"S0899823X25103115_ref2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix794"},{"key":"S0899823X25103115_ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.19283"},{"key":"S0899823X25103115_ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k2400"},{"key":"S0899823X25103115_ref5","unstructured":"5. Surgical Site Infection Event (SSI) National Healthcare Safety Network. Available at: https:\/\/www.cdc.gov\/nhsn\/pdfs\/pscmanual\/9pscssicurrent.pdf. Accessed 10\/31\/2024"},{"key":"S0899823X25103115_ref8","doi-asserted-by":"publisher","DOI":"10.1136\/ejhpharm-2019-001863"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X25103115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T07:46:43Z","timestamp":1774770403000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X25103115\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":8,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S0899823X25103115"],"URL":"https:\/\/doi.org\/10.1017\/ice.2025.10311","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,29]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}