{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:45:57Z","timestamp":1792118757589,"version":"4.4.0"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0899823X25103504_as1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the incidence of hospital-onset bacteremia and fungemia (HOB) among solid organ malignancy (SOM), hematologic malignancy (HM), and hematopoietic cell transplant (HCT) therapy patients at a large cancer care center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25103504_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A single-center, observational, retrospective analysis was conducted for hospitalizations between January 1, 2018, and September 30, 2024, to identify patients with a first positive blood culture on or after day four of hospitalization. Hospitalizations were grouped into three categories: SOM, HM with HCT, and HM without HCT. The primary objective was to study the incidence of HOB. Secondary objectives: identification of risk factors for HOB events and pathogens associated with HOB events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25103504_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In 45,896 admissions, 1,470 HOB events were identified (incidence: 3.2%). The incidence of HOB was highest in the HM\/HCT cohort (3.8%), followed by HM without HCT (2.3%) and SOM (0.9%). Risk factors of HOB identified included HM (OR 1.49), hospitalization within the past 90 days (OR 1.50), length of stay greater than or equal to 30 days (OR 6.74), intensive care unit (ICU) admission (OR 4.06), development of a CAUTI during admission (OR 23.23), or presence of a central line (OR 51.61). The most common pathogens were\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                      (20.1%), coagulase-negative\n                      <jats:italic>Staphylococci<\/jats:italic>\n                      (19.0%), and\n                      <jats:italic>Viridians streptococci<\/jats:italic>\n                      (11.3%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25103504_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study highlights the high incidence of HOB among cancer and HCT patients. The risk factors and differential rates of HOB in subpopulations of this demographic may help to inform targeted infection prevention efforts in cancer centers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/ice.2025.10350","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:27:23Z","timestamp":1763018843000},"page":"124-130","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Incidence of hospital-onset bacteremia and fungemia in solid organ malignancy, hematologic malignancy, and hematopoietic cell transplant patients"],"prefix":"10.1017","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8348-0795","authenticated-orcid":false,"given":"Sara","family":"Kurd-Misto","sequence":"first","affiliation":[{"name":"City of Hope"},{"id":[{"id":"https:\/\/ror.org\/048vrgr14","id-type":"ROR","asserted-by":"publisher"}],"name":"Becton, Dickinson and Company"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8661-6380","authenticated-orcid":false,"given":"Justine","family":"Ross","sequence":"additional","affiliation":[{"name":"City of Hope"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9430-0562","authenticated-orcid":false,"given":"Samantha","family":"Bastow","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/048vrgr14","id-type":"ROR","asserted-by":"publisher"}],"name":"Becton, Dickinson and Company"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4651-2012","authenticated-orcid":false,"given":"Kalvin","family":"Yu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/048vrgr14","id-type":"ROR","asserted-by":"publisher"}],"name":"Becton, Dickinson and Company"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeet","family":"Dadwal","sequence":"additional","affiliation":[{"name":"City of Hope"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"S0899823X25103504_ref8","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2023.132"},{"key":"S0899823X25103504_ref6","unstructured":"6. National Quality Forum. Hospital-Onset Bacteremia and Fungemia Playbook. Washington, DC: National Quality Forum; September 2024. Available at: https:\/\/www.qualityforum.org\/Publications\/2024\/9\/Hospital-Onset_Bacteremia_and_Fungemia_Playbook.aspx."},{"key":"S0899823X25103504_ref12","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0202-8"},{"key":"S0899823X25103504_ref9","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2025.13"},{"key":"S0899823X25103504_ref2","unstructured":"2. Monegro, AF , Muppidi, V , Regunath, H. Hospital-Acquired Infections [Updated 2023 Feb 12]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK441857\/."},{"key":"S0899823X25103504_ref1","unstructured":"1. Centers for Disease Control and Prevention. About HAIs. Healthcare-Associated Infections (HAIs). Published May 17, 2024. https:\/\/www.cdc.gov\/healthcare-associated-infections\/about\/index.html."},{"key":"S0899823X25103504_ref14","unstructured":"14. 2019 HAI Progress Report | CDC. Cdc.gov. Published October 19, 2021. https:\/\/archive.cdc.gov\/www_cdc_gov\/hai\/data\/archive\/2019-HAI-progress-report.html."},{"key":"S0899823X25103504_ref5","doi-asserted-by":"publisher","DOI":"10.1017\/ash.2023.486"},{"key":"S0899823X25103504_ref3","unstructured":"3. U.S. Department of Health and Human Services. National HAI Targets & Metrics. HHS.gov. Published September 2, 2021. https:\/\/www.hhs.gov\/oidp\/topics\/health-care-associated-infections\/targets-metrics\/index.html."},{"key":"S0899823X25103504_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2017.05.003"},{"key":"S0899823X25103504_ref16","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2022.211"},{"key":"S0899823X25103504_ref15","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix947"},{"key":"S0899823X25103504_ref4","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2024.26"},{"key":"S0899823X25103504_ref21","first-page":"147","article-title":"Bacterial translocation from the gastrointestinal tract","volume":"7","author":"Berg","year":"1999","journal-title":"Trends Microbiol"},{"key":"S0899823X25103504_ref7","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx163.336"},{"key":"S0899823X25103504_ref13","first-page":"475","article-title":"Intensive oral care can reduce bloodstream infection with coagulase-negative staphylococci after neutrophil engraftment in allogeneic hematopoietic stem-cell transplantation","volume":"30","author":"Suwabe","year":"2022","journal-title":"Support Care Cancer"},{"key":"S0899823X25103504_ref20","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00793-21"},{"key":"S0899823X25103504_ref18","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa778"},{"key":"S0899823X25103504_ref11","doi-asserted-by":"publisher","DOI":"10.1093\/jleuko\/qiae250"},{"key":"S0899823X25103504_ref17","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-022-01851-y"},{"key":"S0899823X25103504_ref10","first-page":"1","article-title":"Clinical characteristics associated with hospital-onset bacteremia and fungemia among cancer and transplant patients","volume":"23","author":"Yu","year":"2024","journal-title":"Infect Control Hosp Epidemiol"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X25103504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:39:23Z","timestamp":1792118363000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X25103504\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,13]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S0899823X25103504"],"URL":"https:\/\/doi.org\/10.1017\/ice.2025.10350","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,13]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}