{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:33:10Z","timestamp":1785407590881,"version":"3.56.0"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec id=\"S0899823X2510370X_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      An improved understanding of the epidemiology of hospital-onset methicillin-resistant\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      bloodstream infection (HO-MRSA BSI) could inform future prevention strategies for HO-MRSA BSI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X2510370X_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We performed a retrospective cohort study of HO-MRSA BSI reported to NHSN from 2020\u20132023 at a system of 9 acute care hospitals located in New York City. The primary outcome was to describe the demographic and clinical characteristics of patients with HO-MRSA BSI. Secondary outcomes included comparisons of tertiary (TH) and community (CH) hospitals, standardized infection ratio (SIR) and rates per 10,000 patient-discharges, presumptive potential infectious sources, and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X2510370X_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Between 2020 and 2023, 222 patients had HO-MRSA BSI. Their median age was 65 years, 139 (63%) were male, 92 (41%) had central lines, 89 (40%) were in ICUs, and 63 (28%) were on a ventilator. These characteristics were similar across the 176 (79%) patients in TH and the 46 (21%) patients in CH. SIRs were similar across each year of the study (with cumulative SIRs of 0.815 overall, 1.412 [CH] and 0.732 [TH]). Overall HO-MRSA BSI rates ranged from 2.58\u20133.53 per 10,000 patient-discharges. The most common sources of HO-MRSA BSI were pneumonia (41%), SSTIs (17%), CLABSIs (13%), and PIV catheter-related issues (9%). The all-cause mortality rate was 35%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X2510370X_as4\">\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>The unchanged HO-MRSA BSI SIRs in this study support the need for additional interventions that focus on prevention of the primary sources of MRSA infections. Ongoing systematic surveillance of the primary sources of HO-MRSA BSI should be implemented to inform and monitor best practices for prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/ice.2025.10370","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T12:12:44Z","timestamp":1765282364000},"page":"236-243","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Hospital-onset methicillin-resistant\n                    <i>Staphylococcus aureus<\/i>\n                    bloodstream infections within tertiary and community hospitals and implications for prevention"],"prefix":"10.1017","volume":"47","author":[{"given":"Harjot Kaur","family":"Singh","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02r109517","id-type":"ROR","asserted-by":"publisher"}],"name":"Weill Cornell Medicine"},{"id":[{"id":"https:\/\/ror.org\/02r109517","id-type":"ROR","asserted-by":"publisher"}],"name":"NewYork-Presbyterian Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Ross","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02r109517","id-type":"ROR","asserted-by":"publisher"}],"name":"NewYork-Presbyterian Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Hannah","sequence":"additional","affiliation":[{"name":"Columbia University Mailman School of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3286-4563","authenticated-orcid":false,"given":"Serena","family":"Ting","sequence":"additional","affiliation":[{"name":"Columbia University Mailman School of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9165-8972","authenticated-orcid":false,"given":"Chloe","family":"Teasdale","sequence":"additional","affiliation":[{"name":"The City University of New York School of Public Health and Health Policy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6811-2733","authenticated-orcid":false,"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02r109517","id-type":"ROR","asserted-by":"publisher"}],"name":"NewYork-Presbyterian Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Quinn","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02r109517","id-type":"ROR","asserted-by":"publisher"}],"name":"NewYork-Presbyterian 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Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5011-4290","authenticated-orcid":false,"given":"Tina","family":"Wang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02r109517","id-type":"ROR","asserted-by":"publisher"}],"name":"NewYork-Presbyterian Hospital"},{"name":"Columbia University Irving Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuwan","family":"Gunawardhana","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02r109517","id-type":"ROR","asserted-by":"publisher"}],"name":"NewYork-Presbyterian Hospital"},{"name":"Columbia University Irving Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Golderg","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02r109517","id-type":"ROR","asserted-by":"publisher"}],"name":"NewYork-Presbyterian Hospital"},{"name":"NewYork-Presbyterian 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Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Furuya","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02r109517","id-type":"ROR","asserted-by":"publisher"}],"name":"NewYork-Presbyterian Hospital"},{"name":"Columbia University Irving Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Westervelt","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7231-8451","authenticated-orcid":false,"given":"Lisa","family":"Saiman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02r109517","id-type":"ROR","asserted-by":"publisher"}],"name":"NewYork-Presbyterian Hospital"},{"name":"Columbia University Irving Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"S0899823X2510370X_ref1","unstructured":"1. Centers for Disease Control and Prevention. Centers for Medicaid and Medicare Services Operational Guidance for Acute Care Hospitals to Report FACWIDEIN MRSA LabId Event Data, 2019. https:\/\/www.cdc.gov\/nhsn\/pdfs\/cms\/final-ach-mrsa-bacteremia-guidance.pdf. Accessed May 2025."},{"key":"S0899823X2510370X_ref13","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2023.170"},{"key":"S0899823X2510370X_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2023.06.002"},{"key":"S0899823X2510370X_ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-1029-z"},{"key":"S0899823X2510370X_ref9","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaf282"},{"key":"S0899823X2510370X_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.infpip.2023.100271"},{"key":"S0899823X2510370X_ref3","unstructured":"3. National Healthcare Safety Network (NHSN) Bloodstream Infection Event (Central Line-Associated Bloodstream Infection and Non-central Line Associated Bloodstream Infection), 2024. https:\/\/www.cdc.gov\/nhsn\/pdfs\/pscmanual\/pcsmanual_current.pdf. Accessed December 2024. https:\/\/www.cdc.gov\/nhsn\/pdfs\/pscmanual\/pcsmanual_current.pdf, 2024."},{"key":"S0899823X2510370X_ref20","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1207290"},{"key":"S0899823X2510370X_ref5","unstructured":"5. Centers for Disease Control and Prevention. HAI Pathogens and Antimicrobial Resistance Report: 2018-2021. https:\/\/www.cdc.gov\/nhsn\/hai-report\/index.html. Accessed May 2025."},{"key":"S0899823X2510370X_ref7","unstructured":"7. Centers for Disease Control and Prevention. National Health Services Network. Patient Safety Analysis Resources. https:\/\/www.cdc.gov\/nhsn\/pdfs\/ps-analysis-resources\/statscalc.pdf. Accessed August 2025."},{"key":"S0899823X2510370X_ref2","unstructured":"2. National Healthcare Safety Network (NHSN). Patient Safety Component Manual, 2024. https:\/\/www.cdc.gov\/nhsn\/pdfs\/pscmanual\/pcsmanual_current.pdf. Accessed December 2024."},{"key":"S0899823X2510370X_ref18","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2024.0422"},{"key":"S0899823X2510370X_ref16","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2022.88"},{"key":"S0899823X2510370X_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2021.07.046"},{"key":"S0899823X2510370X_ref12","doi-asserted-by":"publisher","DOI":"10.1136\/bmjqs-2023-016831"},{"key":"S0899823X2510370X_ref4","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2023.102"},{"key":"S0899823X2510370X_ref11","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01157-10"},{"key":"S0899823X2510370X_ref6","unstructured":"6. Centers for Disease Control and Prevention. The NHSN Standardized Infection Ratio (SIR). https:\/\/www.cdc.gov\/nhsn\/pdfs\/ps-analysis-resources\/nhsn-sir-guide.pdf. Accessed March 2025."},{"key":"S0899823X2510370X_ref8","unstructured":"8. Centers for Disease Control and Prevention. COVID-19 Impact on Hospital Acquired Infections, 2024. https:\/\/www.cdc.gov\/healthcare-associated-infections\/php\/data\/covid-impact.html. Accessed May 2025."},{"key":"S0899823X2510370X_ref19","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.7202"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X2510370X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T10:33:22Z","timestamp":1771929202000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X2510370X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,9]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S0899823X2510370X"],"URL":"https:\/\/doi.org\/10.1017\/ice.2025.10370","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,9]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}